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This book explores the latest developments in the field the acute phase protein (APP), C-reactive protein or CRP in different diseases, highlighting the structural and functional aspects of CRP in disease biology. Divided into 5 sections, the book examines important topics such as the role of CRP in neurodegenerative, cardiac and parasitic diseases, as well as in cancer and inflammatory bowel disease, and the expression of CRP in pediatric respiratory diseases. In addition it discusses the clinical role of CRP in diagnostics and therapeutics, sepsis, ICU and ITU patients, and also as a primary marker for inflammation. Given its scope, this book will appeal to scholars in various fields of medicine and biology.
This volume includes the latest diagnostic criteria for PCOS and comprises the most up-to-date information about the genetic features and pathogenesis of PCOS. It critically reviews the methodological approaches and the evidence for various PCOS susceptibility genes. The book also discusses additional familial phenotypes of PCOS and their potential genetic basis. All four editors of this title are extremely prominent in the field of PCOS.
The first comprehensive resource on CRP--a powerful new way to assess heart attack risk Half of all heart attacks and strokes occur in people with normal cholesterol levels--a phenomenon that has long baffled doctors. C-Reactive Protein, or CRP, is a newly discovered measure of inflammation in the body that some researchers believe is twice as important as cholesterol in predicting one's risk of heart disease. C-Reactive Protein is the first comprehensive consumer book on the subject. CRP is quickly becoming a hot topic in the media, and public awareness about CRP is growing. The American Heart Association and the Centers for Disease Control now recommend that some 40 million Americans have their CPR levels tested as part of their regular physical. Written by an awardwinning cardiologist, this book explains what CRP means to one's health and shows readers step-by-step how to keep CRP under control. Readers will find: Important advice on what to do if CRP levels are high Lifesaving information on nutrition, supplements, and medications Instructions for getting CRP levels tested and more
This book offers a comprehensive study of C-reactive protein (CRP) belonging to the pentraxin family, including a brief history of CRP, its structure, synthesis and evolution. Focusing on the emerging role of CRP and its clinical application in the field of disease biology, it details the pathophysiological role of CRP in a host of diseases such as cardiovascular disease, diabetes, cancers, rheumatoid arthritis and infectious diseases and others. It also discusses the role of innate immunity and acute phase response (APR) and their key mediators in the host body in response to tissue injury, infection, trauma or surgery, immunological disorders or neoplastic growth. CRP’s significance in inflammation is highlighted, and its importance as a clinical marker in cardiovascular disease, its functional significance in Leishmania and Plasmodium infections, its association with the development of insulin resistance in type 2 diabetes mellitus, and its role in cancer are discussed in detail. The book also includes clinical data studies and presents the latest research advances to further readers’ understanding of CRP.
Over recent years, native pentameric C-reactive protein (pCRP) and its biologically active dissociated form, monomer monomeric CRP (mCRP) have assumed an important role in disease development and pathophysiology. In this series, we have highlighted the thoughts and research of the most eminent scientists in the field of CRP research. This eBook is a collection of original articles and reviews on the subject, creating an archive of current knowledge and understanding. This Research Topic provides new findings of the role of CRP in the fields of neuroscience, cardiovascular disease, inflammation, and macular degeneration as well as defined links to stages in pathological disease progression. These articles explain the mechanisms and pathways through which the dissociated mCRP interacts with a variety of cells, and provide possible prognostic implications and new methods for analysis. Over the coming years, the importance and fascination of the active role of CRP in health and disease is set to rise, and we hope this collection will serve as a valuable reference for these future investigations.
Practical and concise, this manual is a quick, go-to reference for up-to-date clinical material on today’s diagnostic testing and laboratory tests. Three convenient sections provide quick access to key information on clinical laboratory testing, diagnostic imaging, and diagnostic algorithms. Experienced author Dr. Fred Ferri uses a unique, easy-to-follow format to simplify complex information and help you choose the best test to supplement your clinical diagnostic skills. Features a new appendix on when to use contrast agents in ordering CT and MRI scans. Discusses new modalities including transient elastography (Fibroscan), CT enterography and CT enteroclysis. Provides new comparison tables to easily evaluate the best test; new algorithms for evaluation of immunodeficiency and hematochezia; and new tables and illustrations throughout to improve your test selection.
Up-to-date, authoritative and comprehensive, Heart Failure, 4th Edition, provides the clinically relevant information you need to effectively manage and treat patients with this complex cardiovascular problem. This fully revised companion to Braunwald’s Heart Disease helps you make the most of new drug therapies such as angiotensin receptor neprilysin inhibitors (ARNIs), recently improved implantable devices, and innovative patient management strategies. Led by internationally recognized heart failure experts Dr. G. Michael Felker and Dr. Douglas Mann, this outstanding reference gives health care providers the knowledge to improve clinical outcomes in heart failure patients. Focuses on a clinical approach to treating heart failure, resulting from a broad variety of cardiovascular problems. Covers the most recent guidelines and protocols, including significant new updates to ACC, AHA, and HFSA guidelines. Covers key topics such as biomarkers and precision medicine in heart failure and new data on angiotensin receptor neprilysin inhibitors (ARNIs). Contains four new chapters: Natriuretic Peptides in Heart Failure; Amyloidosis as a Cause of Heart Failure; HIV and Heart Failure; and Neuromodulation in Heart Failure. Covers the pathophysiological basis for the development and progression of heart failure. Serves as a definitive resource to prepare for the ABIM’s Heart Failure board exam. 2016 British Medical Association Award: First Prize, Cardiology (3rd Edition).
Severe Community Acquired Pneumonia is a book in which chapters are authored and the same topics discussed by North American and European experts. This approach provides a unique opportunity to view the different perspectives and points of view on this subject. Severe CAP is a common clinical problem encountered in the ICU setting. This book reviews topics concerning the pathogenesis, diagnosis and management of SCAP. The discussions on the role of alcohol in severe CAP and adjunctive therapies are important topics that further our understanding of this severe respiratory infection.
C-reactive protein (CRP) is a protein produced as part of the inflammatory process. It is a routine test for heart failure; high levels of CRP may predict a bad outcome. (However, it is an unreliable test for heart failure, because inflammation from other causes also raises CRP.) CRP is a plasma protein, an acute phase protein produced by the liver and by adipocytes. It is a member of the pentraxin family of proteins. It is not related to C-peptide or protein C. This book presents the latest research from around the world in this field.