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In recent years, there has been an increased interest in exploring the connections between various disciplines of mathematics and theoretical physics such as representation theory, algebraic geometry, quantum field theory, and string theory. One of the challenges of modern mathematical physics is to understand rigorously the idea of quantization. The program of quantization by branes, which comes from string theory, is explored in the book. This open access book provides a detailed description of the geometric approach to the representation theory of the double affine Hecke algebra (DAHA) of rank one. Spherical DAHA is known to arise from the deformation quantization of the moduli space of SL(2,C) flat connections on the punctured torus. The authors demonstrate the study of the topological A-model on this moduli space and establish a correspondence between Lagrangian branes of the A-model and DAHA modules. The finite-dimensional DAHA representations are shown to be in one-to-one correspondence with the compact Lagrangian branes. Along the way, the authors discover new finite-dimensional indecomposable representations. They proceed to embed the A-model story in an M-theory brane construction, closely related to the one used in the 3d/3d correspondence; as a result, modular tensor categories behind particular finite-dimensional representations with PSL(2,Z) action are identified. The relationship of Coulomb branch geometry and algebras of line operators in 4d N = 2* theories to the double affine Hecke algebra is studied further by using a further connection to the fivebrane system for the class S construction. The book is targeted at experts in mathematical physics, representation theory, algebraic geometry, and string theory. This is an open access book.
The emergent mathematical philosophy of categorification is reshaping our view of modern mathematics by uncovering a hidden layer of structure in mathematics, revealing richer and more robust structures capable of describing more complex phenomena. Categorification is a powerful tool for relating various branches of mathematics and exploiting the commonalities between fields. It provides a language emphasizing essential features and allowing precise relationships between vastly different fields. This volume focuses on the role categorification plays in geometry, topology, and physics. These articles illustrate many important trends for the field including geometric representation theory, homotopical methods in link homology, interactions between higher representation theory and gauge theory, and double affine Hecke algebra approaches to link homology. The companion volume (Contemporary Mathematics, Volume 683) is devoted to categorification and higher representation theory.
This book pedagogically describes recent developments in gauge theory, in particular four-dimensional N = 2 supersymmetric gauge theory, in relation to various fields in mathematics, including algebraic geometry, geometric representation theory, vertex operator algebras. The key concept is the instanton, which is a solution to the anti-self-dual Yang–Mills equation in four dimensions. In the first part of the book, starting with the systematic description of the instanton, how to integrate out the instanton moduli space is explained together with the equivariant localization formula. It is then illustrated that this formalism is generalized to various situations, including quiver and fractional quiver gauge theory, supergroup gauge theory. The second part of the book is devoted to the algebraic geometric description of supersymmetric gauge theory, known as the Seiberg–Witten theory, together with string/M-theory point of view. Based on its relation to integrable systems, how to quantize such a geometric structure via the Ω-deformation of gauge theory is addressed. The third part of the book focuses on the quantum algebraic structure of supersymmetric gauge theory. After introducing the free field realization of gauge theory, the underlying infinite dimensional algebraic structure is discussed with emphasis on the connection with representation theory of quiver, which leads to the notion of quiver W-algebra. It is then clarified that such a gauge theory construction of the algebra naturally gives rise to further affinization and elliptic deformation of W-algebra.
Throughout recent history, the theory of knot invariants has been a fascinating melting pot of ideas and scientific cultures, blending mathematics and physics, geometry, topology and algebra, gauge theory, and quantum gravity. The 2013 Séminaire de Mathématiques Supérieures in Montréal presented an opportunity for the next generation of scientists to learn in one place about the various perspectives on knot homology, from the mathematical background to the most recent developments, and provided an access point to the relevant parts of theoretical physics as well. This volume presents a cross-section of topics covered at that summer school and will be a valuable resource for graduate students and researchers wishing to learn about this rapidly growing field.
This first volume develops factorization algebras with a focus upon examples exhibiting their use in field theory, which will be useful for researchers and graduates.
Covering a broad range of topics in differential, algebraic and symplectic geometry, and also in mathematical physics, this volume will be of interest to researchers and graduate students in geometry and mathematical physics.
The collection of chapters in this proceeding volume reflects the latest research presented at the Aegean meeting on Tumor Microenvironment and Cellular Stress held in Crete in Fall of 2012. The book provides critical insight to how the tumor microenvironment affects tumor metabolism, cell stemness, cell viability, genomic instability and more. Additional topics include identifying common pathways that are potential candidates for therapeutic intervention, which will stimulate collaboration between groups that are more focused on elucidation of biochemical aspects of stress biology and groups that study the pathophysiological aspects of stress pathways or engaged in drug discovery.
This book reviews a number of spectacular advances that have been made in the study of supersymmetric quantum field theories in the last few years. Highlights include exact calculations of Wilson loop expectation values, and highly nontrivial quantitative checks of the long-standing electric-magnetic duality conjectures The book starts with an introductory article presenting a survey of recent advances, aimed at a wide audience with a background and interest in theoretical physics. The following articles are written for advanced students and researchers in quantum field theory, string theory and mathematical physics, our goal being to familiarize these readers with the forefront of current research. The topics covered include recent advances in the classification and vacuum structure of large families of N=2 supersymmetric field theories, followed by an extensive discussion of the localisation method, one of the most powerful tools for exact studies of supersymmetric field theories. The quantities that have been studied in this way are partition functions, expectation values of line operators, and supersymmetric indices. The book also reviews recently discovered connections between SUSY field theories in four dimensions and two-dimensional conformal field theory. These connections have a counterpart in relations between three-dimensional gauge theories and Chern-Simons theory; the book’s closing chapters explore connections with string theory.
To you the reader, the joy of discovery begins, for We continue in our goal of providing a text which us the job is done. In this edition, we have corrected is useful, not only to the clinician, but of equal interest past deficiencies, added new topics, expanded infor- to the investigator. The selection of content has been mation regarding the pediatric age group, provided directed at topics of current interest rather than those up to date (March 2003) references, while remaining of historic contribution. We have stressed the cont- true to our concept of a multi-national author book. bution of cell biology and pathophysiology, were it We continue to believe that scientific information is an exists, believing it provides both a better understa- international commodity whose interpretation and ap- ing of toxic injury when known, and a rational dir- plication are strongly influenced by both the cultural tion for therapy and prevention. and ethnic background of the observer. The oppor- nity to share in the rich diversity of the international We are encouraged by the accumulation of rec- scientific community remains a fundamental goal of nized risk factors, which allow pre-treatment strati- this endeavor. To participate as equals leads to mu- cation of our patients’ relative risk and allow us to - tual respect and peer appreciation. The sharing of in- cus our preventative techniques on the individuals tellectual resources fostered by this effort should and most likely to gain the greatest benefit.
"Infection in the Compromised Host" has become a classic chapter in textbooks devoted to infectious diseases and internal medicine. The numbers of compromised hosts are increasing in the era of modem medicine because of our expanded capabilities to deal with difficult diseases, especially neoplasms. As a consequence, microbiologic complications related to the intensive care administered to these patients are increasing as well. Under these circum stances, not only does the underlying illness create conditions favorable for the development of unusual infections, but often the therapy contributes to the acquisition of potential pathogens that turn into agents responsible for severe and frequently fatal disease. Granulocytopenia and immunosuppression have been the two key fac tors in predisposing patients with cancer and other serious diseases to severe bacterial infections. Colonization by hospital-acquired pathogens and breaks in the anatomic barriers-as a result of disease or medical intervention-have contributed to the high incidence of infectious diseases in these patients. Although there is some overlap between the types of infection in granulocytopenic and immunosuppressed hosts, each ofthese clinical entities has distinctive features thatjustify considering them separately, reserving the term immunocompromised hosts only when refer ring to patients who are predisposed to opportunistic infections. For about two decades, infections in granulocytopenic patients have attracted the atten tion of clinicians because they represent a model for the study of antimicrobial drugs in hosts deprived of an essential element of defense against bacterial infection, that is, an adequate number of normally functioning granulocytes.