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This book explores the molecular mechanisms of iron hemostasis in the brain and discusses the cognitive and behavioral implications of iron deficiency. It presents the effect of iron dysregulation on neurophysiological mechanisms. The book provides an overview of iron metabolism and homeostasis at the cellular level and its regulation at the mRNA translation level. It emphasizes the importance of iron for brain development in fetal and early life in preterm infants. Further, it presents iron metabolism as a therapeutic target for novel pharmacological treatment against neurodevelopmental diseases and neurodegenerative disorders. It discusses the role of iron deficiency in sleep disorders and offers diagnosis and treatment of iron-related CNS diseases. Finally, it relates dysregulated expression of iron-related genes in brain tumors. ​​
This book discusses normal brain physiology and renal physiology, as well as the interactions between the two. The physiology of the brain can easily be affected by any changes to the physiology of other systems, which in turn may compromise cerebral blood flow and oxygenation. Together the brain and the renal system help our body systems to function automatically. The book addresses the basic aspects of neurophysiology and renal physiology in three broad sections, the first of which covers the basic principles of cerebral physiology and neural regulation of the renal system. The second part reviews the normal physiology of the renal system, including the mechanism of action, while the last section summarizes the correlation between the brain and kidney. Highly informative and clearly structured, the book provides essential insights for anyone with an interest in physiology and medicine.
This book comprehensively reviews the relationship between micronutrients and brain in health and diseases. It explains the relationship between micronutrients and brain functions, neurogenesis, and cognitive functions. The book also explores the relationship between micronutrients and brain disorders including depression, epilepsy, PD, and Autism. It further explores the recent advancements in understanding the important role of micronutrients as therapeutics in various brain disorders like TBI and AD. Lastly, it presents an overview of micronutrients as neuroprotective agents along with the main principles of nutrigenomics.
Iron is an essential element for almost all organisms, a cofactor playing a crucial role in a number of vital functions, including oxygen transport, DNA synthesis, and respiration. However, its ability to exchange electrons renders excess iron potentially toxic, since it is capable of catalyzing the formation of highly poisonous free radicals. As a consequence, iron homeostasis is tightly controlled by sophisticated mechanisms that have been partially elucidated. Because of its biological importance, numerous disorders have been recently linked to the deregulation of iron homeostasis, which include not only the typical disorders of iron overload and deficiency but also cancer and neurodegenerative diseases. This leads iron metabolism to become an interesting therapeutic target for novel pharmacological treatments against these diseases. Several therapies are currently under development for hematological disorders, while other are being considered for different pathologies. The therapeutic targeting under study includes the hepcidin/ferroportin axis for the regulation of systemic iron homeostasis, complex cytosolic machineries for the regulation of the intracellular iron status and its association with oxidative damage, and reagents exploiting proteins of iron metabolism such as ferritin and transferrin receptor. A promising potential target is a recently described form of programmed cell death named ferroptosis, in which the role of iron is essential but not completely clarified. This Special Issue has the aim to summarize the state-of-the-art, and the latest findings published in the iron field, as well as to elucidate future directions.
Combine the surprising truth about brain food with the cutting-edge science of brain metabolism to achieve extraordinary improvements to your emotional, cognitive, and physical health.​ Are you struggling with attention problems, mood swings, food obsession, or depression? Whatever the issue, you have far more control over your thoughts, feelings, and behavior than you realize. Although medications may bring some relief, in Change Your Diet, Change Your Mind, Dr. Georgia Ede reveals that the most powerful way to change brain chemistry is with food, because that’s where brain chemicals come from in the first place. In this provocative, illuminating guide, Dr. Ede explains why nearly everything we think we know about brain-healthy diets is wrong. We've been told the way to protect our brains is with superfoods, supplements, and plant-based diets rich in whole grains and legumes, but the science tells a different story: not only do these strategies often fail, but some can even work against us. The truth about brain food is that meat is not dangerous, vegan diets are not healthier, and antioxidants are not the answer. Change Your Diet, Change Your Mind will empower you to: understand how unscientific research methods drive fickle nutrition headlines and illogical dietary guidelines weigh the risks and benefits of your favorite foods so you can make your own informed choices about what to eat evaluate yourself for signs of insulin resistance—the silent metabolic disease that robs your brain of the energy it needs to thrive improve your mental health with a choice of moderate-carbohydrate and ketogenic diets that you can personalize to your food preferences and health goals Drawing on a wide range of scientific disciplines including biochemistry, neuroscience, and botany, Dr. Ede will ignite your curiosity about the fascinating world of food and its role in nourishing, protecting, and energizing your brain.
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Alzheimer’s disease is one of the biggest emerging public health problems in the world. Although the last four decades have yielded important insights into the pathogenesis of Alzheimer’s disease, its cause is still unclear, and if it is not discovered the world will face an unprecedented healthcare problem by the middle of this century. In recent years, evidence of the microbial origin of various chronic inflammatory disorders – including several neurodegenerative, neuropsychiatric and other systemic disorders – has been steadily growing. Accumulating new and historic observations are providing evidence of an association between Alzheimer’s disease and certain infectious agents, and may offer new opportunities for ground-breaking healthcare solutions. This handbook assembles and connects findings with regard to the infectious origin of Alzheimer’s disease, and the data presented in its chapters deserves the attention of the neuroscience community, physicians and the health departments of governments worldwide by virtue of its amount and quality. This handbook offers a comprehensive overview of the current knowledge regarding the topic of infection and Alzheimer’s disease, which could pinpoint the cause of this disease. Influential diagnosis, treatment and prevention strategies may also emerge from this crucial research area.
Within the United Kingdom (UK), most mainstream healthcare practitioners receive little or no nutrition education during their years of training. As a consequence, the understanding of nutrition amongst primary care practitioners such as general practitioners, pharmacists, midwives, and practice nurses is limited and is largely focused on energy consumption and obesity. There is little knowledge of the wealth of micronutrients that underpin health, nor of the ticking timebomb of insufficient intakes of those micronutrients amongst a significant proportion of the population in the UK. The Building Blocks of Life: A Nutrition Foundation for Healthcare Professionals is a step towards redressing that balance. It sets out an informative and engaging narrative on how and why nutrition is the basis for good health. It discusses UK-specific issues with regards to diet and intakes of vitamins, minerals, essential fatty acids and other micronutrients. It also raises concerns about the potential negative health implications of the generally poor UK diet and suggests ways that healthcare practitioners can support patients in improving their long-term health outlook. Nutrition policy in the UK needs to be dragged into the 21st century and this book sets out evidence-based arguments which challenge current public health myths such as the idea that 10 micrograms of vitamin D is all anyone needs or the messaging around the consumption of saturated fat vs highly processed seed oils or that everyone can get all the nutrients they need from a varied and balanced diet. Although The Building Blocks of Life: A Nutrition Foundation for Healthcare Professionals focuses on concerns around poor diet and the consequent micronutrient inadequacies in the UK, the nutritional detail is relevant no matter where you are in the world. Everyone eats, all the time. It is time that mainstream medicine looked towards food as both a cause and a solution to many of the chronic degenerative conditions that plague modern life.
The iron element (Fe) is strictly required for the survival of most forms of life, including bacteria, plants and humans. Fine-tuned regulatory mechanisms for Fe absorption, mobilization and recycling operate to maintain Fe homeostasis, the disruption of which leads to Fe overload or Fe depletion. Whereas the deleterious effect of Fe deficiency relies on reduced oxygen transport and diminished activity of Fe-dependent enzymes, the cytotoxicity induced by Fe overload is due to the ability of this metal to act as a pro-oxidant and catalyze the formation of highly reactive hydroxyl radicals via the Fenton chemistry. This results in unfettered oxidative stress generation that, by inducing protein, lipid and DNA oxidation, leads to Fe-mediated programmed cell death and organ dysfunction. Major and systemic Fe overloads occurring in hemochromatosis and Fe-loading anemias have been extensively studied. However, localized tissue Fe overload was recently associated to a variety of pathologies, such as infection, inflammation, cancer, cardiovascular and neurodegenerative disorders. In keeping with the existence of cross-regulatory interactions between Fe homeostasis and the pathophysiology of these diseases, further investigations on the mechanisms that provide cellular and systemic adaptation to tissue Fe overload are instrumental for future therapeutic approaches. Thus, we encourage our colleagues to submit original research papers, reviews, perspectives, methods and technology reports to contribute their findings to a current state of the art on a comprehensive overview of the importance of iron metabolism in pathophysiologic conditions.
Depression is a common mental disorder and one of the leading causes of hospitalization. Simultaneously this disorder is the most notorious vulnerability factor to suicide attempts among men and women. The COVID-19 pandemic (COVID-19-related stressors) resulted in a statistically significant increase in depression incidences. Pharmacological treatment in the clinic is primarily based on substances synthesized in the 1960s and 1970s. High hopes were associated with compounds increasing the level of catecholamines in the brain and reducing excitotoxic levels of glutamate (Glu). However, side effects associated with cognition and psychosis are common. Therefore, it is crucial to synthesize new pharmacologically active substances or combine those used in clinical practice to define further directions in the development of novel more effective therapeutics for depression.