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The topic of bone circulation is relatively new and has developed very quickly in the past 20 years; this book reports on the most recent progress since 1982. The chapters discuss the anatomy of bone vascularization, the physiology of vascular regulation, the histopathology of microcirculation and osteonecrosis, experimental studies on bone-blood flow, experimental surgery, methods of exploration, vascular studies of grafts and bone transfer, and surgical and conservative treatment. New developments are given on blood-bone barrier, effect of PGE2 on blood-bone flow, laser Doppler flowmetry, microcirculation and demineralization, vascular repair in osteotomy and fracture, bone arteriography, angioscintigraphy, Ilizarov's technique, and therapeutic aspects of lipid-clearing agents.
The Association Internationale de Recherche sur la Circulation Osseuse, A.R.C.O., was founded in London in December 1989 by a small group of doctors, surgeons and researchers in basic sciences who had been involved for many years in the study of bone circulation and its disorders. They had met several times in Toulouse, during the International Symposia on Bone Circulation held there since 1973 and they wished to carry their contacts further. In founding A.R.C.O., they established as their primary aims the encouragement and furtherance of research, organisation of meetings and promotion of knowledge on the subject. At the present time, the Association has over a hundred members from more than bone tissue twenty countries in Europe, America and Asia. All have the conviction that and its pathology can only be truly known and studied if one has an understanding of its vascular system and the way its circulation functions. This concept, apparently beyond question, has not yet been adopted by all physicians and scientists who are interested in bone. From time to time, one comes across teaching programmes on bone patho logy which make no mention of bone circulation.
Bone circulation is important to our understanding of many major orthopedic conditions such as osteoarthritis, osteoporosis, repair, and tumors. Yet, circulatory physiology, basic to all healthy organs and most diseases, has been difficult to study in the skeleton. The biological regulation of blood flow is complex and the tissues have been relatively inaccessible to measurement. In recent years, however, advances have been made in understanding circulatory physiology and fluid flow in bone, functional measurement of blood flow, and the roles of circulation in bone turnover and repair. These advances have enhanced our insights into bone homeostasis and the interrelationships of circulation and skeletal biology, including repair and disease.This seminal volume presents updated information on circulatory physiology of bone and fluid flow through the bone matrix. It then describes new techniques in quantifying and imaging bone circulation. A clinical section covering circulatory elements of skeletal diseases provides valuable insight into pathophysiology that may serve as diagnostic biomarkers or therapeutic targets.
Developed by the American Orthopaedic Association and published by AAOS. This unique book addresses virtually every aspect of nontraumatic osteonecrosis. Osteonecrosis documents cutting-edge developments in diagnosis and treatment. Its highly clinical focus helps physicians identify and treat this "silent" disease before major damage occurs. It also enables surgeons to evaluate treatment alternatives, such as core decompression, osteotomy, bone grafting, and arthroplasty. Important research into free vascularized grafting is detailed, including methodology and results from studies carried out in medical centers in the U.S., Canada, Greece, and Italy. The research covers more than 1,300 cases followed up for a minimum of two years. The incidence of osteonecrosis is on the rise, due largely to the increasing use of corticosteroids. Other leading causes include excessive alcohol intake, trauma, blood dyscrasias, hypercoagulability, and dysbaria. Most forms of the disease affect adults under the age of 50. Osteonecrosis brings together the research and discussion of more than 70 physicians and scientists from the U.S. and around the world. Its articles were originally presented at an AOA workshop held at Duke University in November 1996.
Osteonecrosis is a disease caused by reduced blood flow to bones in the joints, including the hip, knee, shoulder, and ankle. The disease, which is usually progressive and leads to joint failure, occurs in young adults aged from their twenties to their fifties. The pathogenesis of osteonecrosis is still unclear, and treatment remains controversial. This textbook provides up-to-date and comprehensive information on the pathophysiology, etiology, diagnosis, classification, and treatment of osteonecrosis. The role of various imaging modalities is considered, and both non-surgical and surgical treatment approaches are clearly explained. The contributions, all from experts in the field, are based on presentations at leading international meetings during the past 10 years and on peer-reviewed papers. The book will be of interest not only to clinical practitioners but also to those engaged in basic research.
Get your hands on this concise, visual guide to orthopaedics packed with the absolutely essential facts!. --Book Jacket.
Fully updated new edition covering all aspects of bone and joint diseases in one easily readable volume. Color illustrations throughout.