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This presentation describes various aspects of the regulation of tissue oxygenation, including the roles of the circulatory system, respiratory system, and blood, the carrier of oxygen within these components of the cardiorespiratory system. The respiratory system takes oxygen from the atmosphere and transports it by diffusion from the air in the alveoli to the blood flowing through the pulmonary capillaries. The cardiovascular system then moves the oxygenated blood from the heart to the microcirculation of the various organs by convection, where oxygen is released from hemoglobin in the red blood cells and moves to the parenchymal cells of each tissue by diffusion. Oxygen that has diffused into cells is then utilized in the mitochondria to produce adenosine triphosphate (ATP), the energy currency of all cells. The mitochondria are able to produce ATP until the oxygen tension or PO2 on the cell surface falls to a critical level of about 4–5 mm Hg. Thus, in order to meet the energetic needs of cells, it is important to maintain a continuous supply of oxygen to the mitochondria at or above the critical PO2 . In order to accomplish this desired outcome, the cardiorespiratory system, including the blood, must be capable of regulation to ensure survival of all tissues under a wide range of circumstances. The purpose of this presentation is to provide basic information about the operation and regulation of the cardiovascular and respiratory systems, as well as the properties of the blood and parenchymal cells, so that a fundamental understanding of the regulation of tissue oxygenation is achieved.
National bestselling author Juliet Marillier revisits the classic fairy tale of Beauty and the Beast in this “engaging Gaelic fantasy romance staring two fascinating reluctant souls”(Genre Go Round Reviews). Whistling Tor is a place of secrets, a mysterious, wooded hill housing the crumbling fortress belonging to Anluan—a chieftain whose name is spoken throughout the region in tones of revulsion and bitterness. A curse lies over Anluan’s family and his people, and the woods themselves hold a perilous force whose every whisper threatens doom. Then the young scribe Caitrin appears in Anluan’s garden, admiring the rare plant known as heart’s blood. Retained to sort through entangled family documents, Caitrin brings about unexpected changes in the household, casting a hopeful light against the despairing shadows. But even as Caitrin brings solace to Anluan, and the promise of something more between them, he remains in thrall to the darkness surrounding Whistling Tor. To free Anluan’s burdened soul, Caitrin must unravel the web of sorcery woven by his ancestors before it claims his life—and their love...
Research centering on blood flow in the heart continues to hold an important position, especially since a better understanding of the subject may help reduce the incidence of coronary arterial disease and heart attacks. This book summarizes recent advances in the field; it is the product of fruitful cooperation among international scientists who met in Japan in May, 1990 to discuss the regulation of coronary blood flow.
The Social Security Administration (SSA) uses a screening tool called the Listing of Impairments to identify claimants who are so severely impaired that they cannot work at all and thus immediately qualify for benefits. In this report, the IOM makes several recommendations for improving SSA's capacity to determine disability benefits more quickly and efficiently using the Listings.
Examines the physiology of deer, and describes how they have had to adapt to man's encroachment on their natural environments in varied parts of the United States.
Without apology, the voices here speak of the verities of the hunt, our connections to the land, and the ethics of blood sport, with essays by the best writers in the field: Edward Abbey, Rick Bass, Tom Beck, Jimmy Carter, Jim Fergus, Barry Lopez, Peter Matthiessen, Tom McGuane, Richard K. Nelson, David Peterson, and Terry Tempest Williams.
A generation past, the western realms were embroiled in endless war. Then the Destroyer came. From the blood and ashes he left behind, a tenuous alliance rose between the barbarian riders of Parsathe and the walled kingdoms of the south. That alliance is all that stands against the return of an ancient evil—until the barbarian king and queen are slain in an act of bloody betrayal. Though forbidden by the alliance council to kill the corrupt king responsible for his parents’ murders, Maddek vows to avenge them, even if it costs him the Parsathean crown. But when he learns it was the king’s daughter who lured his parents to their deaths, the barbarian warrior is determined to make her pay. Yet the woman Maddek captures is not what he expected. Though the last in a line of legendary warrior-queens, Yvenne is small and weak, and the sharpest weapons she wields are her mind and her tongue. Even more surprising is the marriage she proposes to unite them in their goals and to claim their thrones—because her desire for vengeance against her father burns even hotter than his own…
This report considers the biological and behavioral mechanisms that may underlie the pathogenicity of tobacco smoke. Many Surgeon General's reports have considered research findings on mechanisms in assessing the biological plausibility of associations observed in epidemiologic studies. Mechanisms of disease are important because they may provide plausibility, which is one of the guideline criteria for assessing evidence on causation. This report specifically reviews the evidence on the potential mechanisms by which smoking causes diseases and considers whether a mechanism is likely to be operative in the production of human disease by tobacco smoke. This evidence is relevant to understanding how smoking causes disease, to identifying those who may be particularly susceptible, and to assessing the potential risks of tobacco products.
The New York Times bestselling guide to the lifesaving diet that can both prevent and help reverse the effects of heart disease Based on the groundbreaking results of his twenty-year nutritional study, Prevent and Reverse Heart Disease by Dr. Caldwell Esselstyn illustrates that a plant-based, oil-free diet can not only prevent the progression of heart disease but can also reverse its effects. Dr. Esselstyn is an internationally known surgeon, researcher and former clinician at the Cleveland Clinic and a featured expert in the acclaimed documentary Forks Over Knives. Prevent and Reverse Heart Disease has helped thousands across the country, and is the book behind Bill Clinton’s life-changing vegan diet. The proof lies in the incredible outcomes for patients who have followed Dr. Esselstyn's program, including a number of patients in his original study who had been told by their cardiologists that they had less than a year to live. Within months of starting the program, all Dr. Esselstyn’s patients began to improve dramatically, and twenty years later, they remain free of symptoms. Complete with more than 150 delicious recipes perfect for a plant-based diet, the national bestseller Prevent and Reverse Heart Disease explains the science behind the simple plan that has drastically changed the lives of heart disease patients forever. It will empower readers and give them the tools to take control of their heart health.