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Part visceral dream-memoir, part fictive journey through a hallucinatory Bucharest, Mircea Cărtărescu’s Blinding was one of the most widely heralded literary sensations in contemporary Romania, and a bestseller from the day of its release. Riddled with hidden passageways, mesmerizing tapestries, and whispering butterflies, Blinding takes us on a mystical trip into the protagonist’s childhood, his memories of hospitalization as a teenager, the prehistory of his family, a traveling circus, Secret police, zombie armies, American fighter pilots, the underground jazz scene of New Orleans, and the installation of the communist regime. This kaleidoscopic world is both eerily familiar and profoundly new. Readers of Blinding will emerge from this strange pilgrimage shaken, and entirely transformed. From the Trade Paperback edition.
Planning clinical research requires many decisions. The authors of this book explain key decisions with examples showing what works and what does not.
What information should jurors have during court proceedings to render a just decision? Should politicians know who is donating money to their campaigns? Will scientists draw biased conclusions about drug efficacy when they know more about the patient or study population? The potential for bias in decision-making by physicians, lawyers, politicians, and scientists has been recognized for hundreds of years and drawn attention from media and scholars seeking to understand the role that conflicts of interests and other psychological processes play. However, commonly proposed solutions to biased decision-making, such as transparency (disclosing conflicts) or exclusion (avoiding conflicts) do not directly solve the underlying problem of bias and may have unintended consequences. Robertson and Kesselheim bring together a renowned group of interdisciplinary scholars to consider another way to reduce the risk of biased decision-making: blinding. What are the advantages and limitations of blinding? How can we quantify the biases in unblinded research? Can we develop new ways to blind decision-makers? What are the ethical problems with withholding information from decision-makers in the course of blinding? How can blinding be adapted to legal and scientific procedures and in institutions not previously open to this approach? Fundamentally, these sorts of questions—about who needs to know what—open new doors of inquiry for the design of scientific research studies, regulatory institutions, and courts. The volume surveys the theory, practice, and future of blinding, drawing upon leading authors with a diverse range of methodologies and areas of expertise, including forensic sciences, medicine, law, philosophy, economics, psychology, sociology, and statistics. - Introduces readers to the primary policy issue this book seeks to address: biased decision-making. - Provides a focus on blinding as a solution to bias, which has applicability in many domains. - Traces the development of blinding as a solution to bias, and explores the different ways blinding has been employed. - Includes case studies to explore particular uses of blinding for statisticians, radiologists, and fingerprint examiners, and whether the jurors and judges who rely upon them will value and understand blinding.
From a New York Times bestselling author comes the incredible true story of an underage soldier's first love and loss on the battlefields of Bataan and Corregidor—perfect for fans of The Boy Who Followed His Father into Auschwitz and Unbroken. Joe Johnson Jr. ran away from home at the age of 12, hopping a freight train at the height of the Great Depression. He managed to talk his way into the U.S. Army two years later. Seeking freedom and adventure, he was sent to the Philippines. Adrift in spirit, Joe visited a teenage prostitute, and they became unlikely, smitten allies. Yet when the Japanese attacked on December 8, 1941, their hopes of being together had to wait. Joe and his fellow soldiers fought for four brutal months in Bataan and Corregidor, until they were forced to surrender. The boy endured years of horror as a prisoner of war, only dreaming about seeing again the girl he’d come to love. This lyrically written and deeply encouraging saga will remind you that every life can be lifted, forgiveness is the patron of restoration, and redemption is available to all.
The second book in the Lightbringer series, the blockbuster fantasy epic from international bestseller Brent Weeks. Perfect for fans of Brandon Sanderson, Robin Hobb and Joe Abercrombie. Gavin Guile is dying. He'd thought he had five years left - now he's got less than one. With fifty thousand refugees, a bastard son and an ex-fiancée who may have learned his darkest secret, Gavin's got problems on every side. As he loses control, the world's magic runs wild, threatening to destroy the Seven Satrapies. The old gods are being reborn and their army of colour wights is unstoppable. The only salvation may be the brother whose freedom and life Gavin stole sixteen years ago. 'Weeks has a style of immediacy and detail that pulls the reader relentlessly into the story. He doesn't allow you to look away' Robin Hobb 'Weeks writes in an inescapably engaging style' Andrea Stewart 'Weeks is a giant of the genre' Nicholas Eames 'Brent Weeks is so good it's beginning to tick me off' Peter V. Brett 'I was mesmerised from start to finish. Unforgettable characters, a plot that kept me guessing, non-stop action and the kind of in-depth storytelling that makes me admire a writers' work' Terry Brooks 'Weeks has truly cemented his place among the great epic fantasy writers of our time' British Fantasy Society Books by Brent Weeks Lightbringer The Black Prism The Blinding Knife The Broken Eye The Blood Mirror The Burning White Night Angel The Way of Shadows Shadow's Edge Beyond the Shadows The Kylar Chronicles Night Angel Nemesis Perfect Shadow: A Night Angel Novella The Way of Shadows: The Graphic Novel
Colorblindness has become an integral part of the national conversation on race in America. Given the assumptions behind this influential metaphor—that being blind to race will lead to racial equality—it's curious that, until now, we have not considered if or how the blind "see" race. Most sighted people assume that the answer is obvious: they don't, and are therefore incapable of racial bias—an example that the sighted community should presumably follow. In Blinded by Sight,Osagie K. Obasogie shares a startling observation made during discussions with people from all walks of life who have been blind since birth: even the blind aren't colorblind—blind people understand race visually, just like everyone else. Ask a blind person what race is, and they will more than likely refer to visual cues such as skin color. Obasogie finds that, because blind people think about race visually, they orient their lives around these understandings in terms of who they are friends with, who they date, and much more. In Blinded by Sight, Obasogie argues that rather than being visually obvious, both blind and sighted people are socialized to see race in particular ways, even to a point where blind people "see" race. So what does this mean for how we live and the laws that govern our society? Obasogie delves into these questions and uncovers how color blindness in law, public policy, and culture will not lead us to any imagined racial utopia.
Poetry. Latinx Studies. Translated by Lisa Allen Ortiz and Sara Daniele Rivera. THE BLINDING STAR collects selected new translations of poems by the Peruvian poet Blanca Varela and includes two of her most experimental works in their entirety: The Book of Clay and Animal Concert. Although Varela has been categorized as a surrealist, this collection reframes her work as existentially feminist. There is nothing arbitrary in Varela's serrated language and carnal obsessions. She is telling the story of a woman's liminal being--her body as both a vessel of expectations and a vast unmapped interior. Octavio Paz described Varela's work as "Both the wound and the knife," and this collection emphasizes the duality of her poetry. These poems journey inward through dark gardens to expose the wound of grief and outward again with sharp clarity. Blanca Varela is a singular artist, furiously searching for fragments of brightness in the merciless landscape of her own mind.
In a web of lies, who can you trust? Ten years ago, Anna Clarke's parents disappeared. The mystery haunts her, and she hopes her job in a busy city Garda Station will one day help her find answers. The case of a man shot dead crosses her desk - and Anna is shocked to discover that the main suspect is her childhood friend Kate Crowley. Certain that Kate is innocent, Anna is determined to help her clear her name. But first she has to find her ... Tom Gallagher's son David is dead, and Tom believes Kate is responsible. Now his older son John is missing - unable to grieve for one son until he finds the other, desperation can cause a man to do terrible things ... Then the German Meier brothers descend on the city, intent on finding an item David had offered to sell them. Even Tom doesn't know where it is, but he suspects Kate Crowley must have taken it. Kate is on the run. She is trapped in the dead man's city - can her old friend help her find a way out? In a week where a political summit is taking place and the city is on high alert, Kate must struggle to stay hidden and stay alive. And Anna is drawn into the twisted race against time, falling deeper into danger.
As essential nutrients, sodium and potassium contribute to the fundamentals of physiology and pathology of human health and disease. In clinical settings, these are two important blood electrolytes, are frequently measured and influence care decisions. Yet, blood electrolyte concentrations are usually not influenced by dietary intake, as kidney and hormone systems carefully regulate blood values. Over the years, increasing evidence suggests that sodium and potassium intake patterns of children and adults influence long-term population health mostly through complex relationships among dietary intake, blood pressure and cardiovascular health. The public health importance of understanding these relationships, based upon the best available evidence and establishing recommendations to support the development of population clinical practice guidelines and medical care of patients is clear. This report reviews evidence on the relationship between sodium and potassium intakes and indicators of adequacy, toxicity, and chronic disease. It updates the Dietary Reference Intakes (DRIs) using an expanded DRI model that includes consideration of chronic disease endpoints, and outlines research gaps to address the uncertainties identified in the process of deriving the reference values and evaluating public health implications.
Praise for the First Edition of Design and Analysis of Clinical Trials "An excellent book, providing a discussion of the clinical trial process from designing the study through analyzing the data, and to regulatory requirement . . . could easily be used as a classroom text to understand the process in the new drug development area." –Statistical Methods in Medicine A complete and balanced presentation now revised, updated, and expanded As the field of research possibilities expands, the need for a working understanding of how to carry out clinical trials only increases. New developments in the theory and practice of clinical research include a growing body of literature on the subject, new technologies and methodologies, and new guidelines from the International Conference on Harmonization (ICH). Design and Analysis of Clinical Trials, Second Edition provides both a comprehensive, unified presentation of principles and methodologies for various clinical trials, and a well-balanced summary of current regulatory requirements. This unique resource bridges the gap between clinical and statistical disciplines, covering both fields in a lucid and accessible manner. Thoroughly updated from its first edition, the Second Edition of Design and Analysis of Clinical Trials features new topics such as: Clinical trials and regulations, especially those of the ICH Clinical significance, reproducibility, and generalizability Goals of clinical trials and target population New study designs and trial types Sample size determination on equivalence and noninferiority trials, as well as comparing variabilities Also, three entirely new chapters cover: Designs for cancer clinical trials Preparation and implementation of a clinical protocol Data management of a clinical trial Written with the practitioner in mind, the presentation assumes only a minimal mathematical and statistical background for its reader. Instead, the writing emphasizes real-life examples and illustrations from clinical case studies, as well as numerous references-280 of them new to the Second Edition-to the literature. Design and Analysis of Clinical Trials, Second Edition will benefit academic, pharmaceutical, medical, and regulatory scientists/researchers, statisticians, and graduate-level students in these areas by serving as a useful, thorough reference source for clinical research.