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Resistance to therapies, both targeted and systemic, and metastases to distant organs are the underlying causes of breast cancer-associated mortality. The second edition of Breast Cancer Metastasis and Drug Resistance brings together some of the leading experts to comprehensively understand breast cancer: the factors that make it lethal, and current research and clinical progress. This volume covers the following core topics: basic understanding of breast cancer (statistics, epidemiology, racial disparity and heterogeneity), metastasis and drug resistance (bone metastasis, trastuzumab resistance, tamoxifen resistance and novel therapeutic targets, including non-coding RNAs, inflammatory cytokines, cancer stem cells, ubiquitin ligases, tumor microenvironment and signaling pathways such as TRAIL, JAK-STAT and mTOR) and recent developments in the field (epigenetic regulation, microRNAs-mediated regulation, novel therapies and the clinically relevant 3D models). Experts also discuss the advances in laboratory research along with their translational and clinical implications with an overarching goal to improve the diagnosis and prognosis, particularly that of breast cancer patients with advanced disease.
6x9/BlackLined/White/120pages A Journal for you to write down your heart's contents, to take notes, practice your creative writing, write down your to-do-lists or simply enjoy journaling.
The outlook for women with breast cancer has improved in recent years. Due to the combination of improved treatments and the benefits of mammography screening, breast cancer mortality has decreased steadily since 1989. Yet breast cancer remains a major problem, second only to lung cancer as a leading cause of death from cancer for women. To date, no means to prevent breast cancer has been discovered and experience has shown that treatments are most effective when a cancer is detected early, before it has spread to other tissues. These two facts suggest that the most effective way to continue reducing the death toll from breast cancer is improved early detection and diagnosis. Building on the 2001 report Mammography and Beyond, this new book not only examines ways to improve implementation and use of new and current breast cancer detection technologies but also evaluates the need to develop tools that identify women who would benefit most from early detection screening. Saving Women's Lives: Strategies for Improving Breast Cancer Detection and Diagnosis encourages more research that integrates the development, validation, and analysis of the types of technologies in clinical practice that promote improved risk identification techniques. In this way, methods and technologies that improve detection and diagnosis can be more effectively developed and implemented.
Absolute Risk: Methods and Applications in Clinical Management and Public Health provides theory and examples to demonstrate the importance of absolute risk in counseling patients, devising public health strategies, and clinical management. The book provides sufficient technical detail to allow statisticians, epidemiologists, and clinicians to build, test, and apply models of absolute risk. Features: Provides theoretical basis for modeling absolute risk, including competing risks and cause-specific and cumulative incidence regression Discusses various sampling designs for estimating absolute risk and criteria to evaluate models Provides details on statistical inference for the various sampling designs Discusses criteria for evaluating risk models and comparing risk models, including both general criteria and problem-specific expected losses in well-defined clinical and public health applications Describes many applications encompassing both disease prevention and prognosis, and ranging from counseling individual patients, to clinical decision making, to assessing the impact of risk-based public health strategies Discusses model updating, family-based designs, dynamic projections, and other topics Ruth M. Pfeiffer is a mathematical statistician and Fellow of the American Statistical Association, with interests in risk modeling, dimension reduction, and applications in epidemiology. She developed absolute risk models for breast cancer, colon cancer, melanoma, and second primary thyroid cancer following a childhood cancer diagnosis. Mitchell H. Gail developed the widely used "Gail model" for projecting the absolute risk of invasive breast cancer. He is a medical statistician with interests in statistical methods and applications in epidemiology and molecular medicine. He is a member of the National Academy of Medicine and former President of the American Statistical Association. Both are Senior Investigators in the Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health.
Invisible Visits analyzes why Black middle-class women continue to face inequities in securing fair, equitable, and high-quality healthcare. Unlike other works on health disparities, it integrates social science, public health, and the humanities to better understand why Black women do not receive a proper standard of care at the doctor.
This atlas illustrates the latest available data on the cancer epidemic, showing causes, stages of development, and prevalence rates of different types of cancers by gender, income group, and region. It also examines the cost of the disease, both in terms of health care and commercial interests, and the steps being taken to curb the epidemic, from research and screening to cancer management programs and health education.
Originally published in 1980, Audre Lorde's The Cancer Journals offers a profoundly feminist analysis of her experience with breast cancer & a modified radical mastectomy. Moving between journal entry, memoir, & exposition, Lorde fuses the personal & political & refuses the silencing & invisibility that she experienced both as a woman facing her own death & as a woman coping with the loss of her breast. After Lorde died of cancer in 1992, women from all over the U.S. & beyond paid tribute to her in essays & poems. Aunt Lute's special hardcover edition of The Cancer Journals gathers together twelve such tributes as well as a series of six photographs taken of Lorde by photographer Jean Weisinger. Tributes by: Margaret E. Cronin, Linda Cue, Elliot, Ayofemi Folayan, Jewelle Gomez, Margaret Randall, Adrienne Rich, Kate Rushin, Elizabeth Sargent, Ann Allen Shockley, Barbara Smith, & Evelyn White.
Sarah McLean's story of courage and perseverance through her two-time battle with breast cancer before the age of 35 will leave readers feeling inspired and encouraged. Her honest, raw perspectives are refreshing. She takes the reader on the emotional roller coaster one faces through this horrific fight, from fear of death to self-image problems to intimacy issues. Her honesty might surprise some, but she finds it an essential part of the healing process. In her battle with cancer, Sarah discovered that in order to move forward, we must start from a place of vulnerability. Sarah's ups and downs allow the women reading Pink Is the New Black, even those still reeling from their diagnosis or hurting from their treatment, even those who find no hope, to recognize that they can't make it through this battle on their own. Sarah's youth and energy differentiate her book from other breast cancer books. She experienced breast cancer at a younger age than most women--she was newly married and hadn't yet had children. Readers will grieve along with Sarah at each new roadblock, cheer with each breakthrough, and know her as a sister by the end of the book.
This timely, up-to-date guide addresses the unique economic and social issues of black women while showing them why and how to breastfeed their children. African American infants are twice as likely to die before their first birthdays as white infants, have the highest rate of asthma of any race and have a 35 percent higher prevalence of childhood obesity than white children. African American women are 2.2 times more likely to die from breast cancer and 30 percent more likely to die from ovarian cancer than white women. All of these health crises can be remedied to some degree with breastfeeding, but virtually all breastfeeding literature on the market fails to speak to the financial, educational and cultural realities of many African American women. The Black Woman's Guide to Breastfeeding addresses the importance of breastfeeding in the African American community and provides all the practical advice African American mothers need to succeed at breastfeeding.