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Although our knowledge of mood disorders is expanding, comparatively little is known about bipolar depression in particular. This book offers the most up-to-date information about the diagnosis, treatment, and research surrounding bipolar depression. Early chapters provide diagnostic information and review the course, outcome and genetics of this heritable condition. The book gives a thorough and unique overview of the neurobiology of the disorder, including neuroimaging work. Several chapters delineate the treatment of bipolar depression in special populations such as children and pregnant women. Furthermore, the particular issues of suicide, focusing on the need for assessment during both acute and maintenance treatment, are addressed. Finally, acute and long-term treatment strategies for bipolar depression are discussed, including both traditional and novel therapeutics, as well as non-pharmacological treatments. This volume offers researchers and clinicians key insights into this devastating disorder.
The Neurobiology of Bipolar Disorder: Road to Novel Therapeutics combines the basic neurobiology of bipolar disorder with discussions of the most recent advances in research, including the interacting pathways implicated in the pathophysiology of bipolar disorder, genetic approaches and the pharmacogenomics of bipolar disorder. The basic foundational understanding of the neurobiology underlying the disorder, along with a comprehensive summary of the most recent advances in research combine to aid advanced students and researchers in their understanding of bipolar disorder management using novel and fast-acting pharmaceutical and neuromodulatory approaches. - Aids readers in understanding bipolar disorder in the context of NIMH Research Domain Criteria (RDoC) recommendations - Covers a range of existing and potential pharmacologic and non-pharmacologic treatment options, from lifestyle adjustments to novel therapeutics - Synthesizes a discussion of the cellular and molecular mechanisms underlying symptoms with clinical aspects of bipolar disorder
This book brings together mental health professionals and researchers to offer the most up-to-date information on the diagnosis, treatment, and research surrounding bipolar depression. Its individual chapters provide valuable diagnostic information, allowing clinicians to distinguish between the various mood disorders. Further, they: review the course, outcome, and genetics of this highly heritable condition; offer a thorough overview of the neurobiology of the disorder, including what is known from neuroimaging work; delineate the treatment of bipolar depression in special populations such as children and pregnant women; address suicide, focusing on the need for assessment during both acute and maintenance treatment with interventions appropriate to a patient’s symptoms and history; and cover acute and long-term treatment strategies for bipolar depression, including both traditional and novel therapeutics for the disorder, as well as non-pharmacological treatments. This second edition reflects significant advances, including an improved understanding of the altered neurobiology of patients suffering from bipolar depression, new information on pathophysiology and genetic findings drawn from diverse studies, and a discussion of the significant strides made towards improved treatment with already available and novel agents.
Provides a one-stop evidence-based guide to the management of all types of mood disorders.
Bipolar disorder is a chronic and debilitating mental illness affecting a significant proportion of the world's population. It is associated with significant impairments in health-related quality of life and psychosocial functioning, and has significant illness-related morbidity and heightened mortality rates due to medical comorbidities and suicide. The management of this disorder requires a complex combination of pharmacological and psychosocial interventions which can be challenging for clinicians. Written by world experts in the field of bipolar disorder, The Treatment of Bipolar Disorder: Integrative Clinical Strategies and Future Directions provides readers with a concise and comprehensive guide to the integrative management of bipolar disorder. This resource contains 31 chapters on the various management choices available, from both established and novel treatment areas, such as psychoeducation, psychotherapeutic interventions, neuromodulatory approaches and novel therapeutic targets. The complexity and diversity of the management choices available makes this a continually evolving field and necessitates forward thinking. By both discussing the current management of bipolar disorder, and the future developments available, this resource provides all clinicians working with patients with bipolar disorder an up-to-date and reflective guide to its management and what the future holds.
The Bipolar Book covers not only clinical and pathophysiological matters, but also technical aspects of the evidence accumulation for treatment of bipolar disorder. This approach brings in stimulating discussions on available data originating from current randomized controlled trials with specified considerations of bipolar mania, depression, and prophylaxis by providing accompanying recommendations for an improved evidence formation and synthesis. The Bipolar Book provides a clinician-friendly view of debatable issues on the existing randomized trials based evidence and the ways of improving them by respecting distinctive fluctuating pattern of bipolar disorder.
Bipolar disorders were once considered rare in children and adolescents. A growing body of scientific evidence now suggests that they may be more prevalent in this group than previously believed. At the same time, the practitioner faces significant clinical challenges in both the assessment processes and also the implementation of a treatment plan. A paucity of treatment manuals and pharmacological algorithms providing practical guidance makes the task of the clinician even more difficult, despite the fact that more is known about the assessment, neurobiology and treatment of children and adolescents with bipolar disorder than ever before. Written by three distinguished experts, this book conveys to clinicians all the information currently available in this area. They review both the neuroscience and also the integration of rational, practical, pharmacological and psychosocial interventions. Based on what is known, a sound approach to the assessment of these youngsters can be developed. Similarly, available evidence allows practitioners to ground their treatment protocols solidly on scientific knowledge. Concise and authoritative, Pediatric Bipolar Disorders will give the reader a practical approach to both the art and science of providing the best possible clinical care to children and adolescents with the disorder. This book is written primarily for clinical psychiatrists, but will also be of interest to non-specialist doctors and other members of the health care team.
Personalized Psychiatry presents the first book to explore this novel field of biological psychiatry that covers both basic science research and its translational applications. The book conceptualizes personalized psychiatry and provides state-of-the-art knowledge on biological and neuroscience methodologies, all while integrating clinical phenomenology relevant to personalized psychiatry and discussing important principles and potential models. It is essential reading for advanced students and neuroscience and psychiatry researchers who are investigating the prevention and treatment of mental disorders. - Combines neurobiology with basic science methodologies in genomics, epigenomics and transcriptomics - Demonstrates how the statistical modeling of interacting biological and clinical information could transform the future of psychiatry - Addresses fundamental questions and requirements for personalized psychiatry from a basic research and translational perspective
Late-life Mood Disorders provides a comprehensive review of the current research advances in neurobiology and psychosocial origins of geriatric mood disorders. The review of the latest developments and "gold standards" of care is provided by an international group of leading experts.
Neuroprogression and Staging in Bipolar Disorder provides a comprehensive and scholarly overview of clinical staging systems in the management of bipolar disorder. The book covers the theoretical basis, the neurobiological underpinnings, the current evidence base, limitations, future directions and the clinical implications and recommendations.