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Advanced Biosensors for Health Care Applications highlights the different types of prognostic and diagnostic biomarkers associated with cancer, diabetes, Alzheimer's disease, brain and retinal diseases, cardiovascular diseases, bacterial infections, as well as various types of electrochemical biosensor techniques used for early detection of the potential biomarkers of these diseases. Many advanced nanomaterials have attracted intense interests with their unique optical and electrical properties, high stability, and good biocompatibility. Based on these properties, advanced nanoparticles have been used as biomolecular carriers, signal producers, and signal amplifiers in biosensor design. Recent studies reported that there are several diagnostic methods available, but the major issue is the sensitivity and selectivity of these approaches. This book outlines the need of novel strategies for developing new systems to retrieve health information of patients in real time. It explores the potential of nano-multidisciplinary science in the design and development of smart sensing technology using micro-nanoelectrodes, novel sensing materials, integration with MEMS, miniaturized transduction systems, novel sensing strategy, that is, FET, CMOS, System-on-a-Chip (SoC), Diagnostic-on-a-Chip (DoC), and Lab-on-a-Chip (LOC), for diagnostics and personalized health-care monitoring. It is a useful handbook for specialists in biotechnology and biochemical engineering. - Describes advanced nanomaterials for biosensor applications - Relates the properties of available nanomaterials to specific biomarkers applications - Includes diagnosis and electrochemical studies based on biosensors - Explores the potential of nano-multidisciplinary science to design and develop smart sensing technologies - Describes novel strategies for developing a new class of assay systems to retrieve the desired health information
Electrochemical Biosensors summarizes fundamentals and trends in electrochemical biosensing. It introduces readers to the principles of transducing biological information to measurable electrical signals to identify and quantify organic and inorganic substances in samples. The complexity of devices related to biological matrices makes this challenging, but this measurement and analysis are critically valuable in biotechnology and medicine. Electrochemical biosensors combine the sensitivity of electroanalytical methods with the inherent bioselectivity of the biological component. Some of these sensor devices have reached the commercial stage and are routinely used in clinical, environmental, industrial and agricultural applications. - Describes several electrochemical methods used as detection techniques with biosensors - Discusses different modifiers, including nanomaterials, for preparing suitable pathways for immobilizing biomaterials at the sensor - Explains various types of signal monitoring, along with several recognition systems, including antibodies/antigens, DNA-based biosensors, aptamers (protein-based), and more
Bioanalytical science and its technological subdomain, biosensors, are ever-evolving subjects, striving for rapid improvement in terms of performance and expanding the target range to meet the vast societal and market demands. The key performance factors for a biosensor that drive the research are selectivity, sensitivity, response time, accuracy, and reproducibility, with additional requirements of its portability and inexpensive nature. These performance factors are largely governed by the materials and techniques being used in these bioanalytical platforms. The selection of materials to meet these requirements is critical, as their interaction or involvement with the biological recognition elements should initiate or improve these performance factors. The technique discussed primarily applies to transducers involved in converting a biochemical signal to optical or electrical signals. Over the years, the emergence of novel materials and techniques has drastically improved the performance of these bioanalytical systems, enabling them to expand their analytical horizon. These advanced materials and techniques are central to modern bioanalytical and biosensor research. Advanced Materials and Techniques for Biosensors and Bioanalytical Applications provides a comprehensive review of the subject, including a knowledge platform for both academics and researchers. Considering biosensors as a central theme to this book, an outline on this subject with background principles has been included, with a scope of extending the utility of the book to coursework in graduate and postgraduate schools. Features: • Basic principles on different classes of biosensors, recent advances and applications • Smart materials for biosensors and other rapid, portable detection devices • Metal nanoparticles and nanocrystals for analytical applications • Carbon-based nanoparticles and quantum dots for sensing applications • Nanozymes as potential catalysts for sensing applications • Bioelectrochemiluminescence and photoelectrochemical-based biosensors • Paper electronics and paper-based biosensors • Microbial biosensors: artificial intelligence, genetic engineering, and synthetic biology • Biofuel cells as a signal transduction platform • FET-based biosensors, including ISFET and BioFET This book serves as a reference for scientific investigators and a textbook for a graduate-level course in biosensors and advanced bioanalytical techniques.
Nanomaterials for Biosensors: Fundamentals and Applications provides a detailed summary of the main nanomaterials used in biosensing and their application. It covers recent developments in nanomaterials for the fabrication of biosensor devices for healthcare diagnostics, food freshness and bioprocessing. The various processes used for synthesis and characterization of nanostructured materials are examined, along with the design and fabrication of bioelectronic devices using nanostructured materials as building blocks. Users will find the fundamentals of the main nanomaterials used in biosensing, helping them visualize a systematic and coherent picture of how nanomaterials are used in biosensors. The book also addresses the role of bio-conjugation of nanomaterials in the construction of nano-biointerfaces for application in biosensors. Such applications, including metal nanoparticles, metal oxide nanoparticles, nanocomposites, carbon nanotubes, conducting polymers and plasmonic nanostructures in biosensing are discussed relative to each nanomaterial concerned. Finally, recent advancements in protein functionalized nanomaterials for cancer diagnostics and bio-imaging are also included. - Provides a detailed study on how nanomaterials are used to enhance sensing capabilities in biosensors - Explains the properties, characterization methods and preparation techniques of the nanomaterials used in biosensing - Arranged in a material-by-material way, making it clear how each nanomaterial should be used
This volume summarizes the state-of-the-art technologies, key advances and future trends in the field of label-free biosensing. It provides detailed insights into the different types of solid-state, label-free biosensors, their underlying transducer principles, advanced materials utilized, device-fabrication techniques and various applications. The book offers graduate students, academic researchers, and industry professionals a comprehensive source of information on all facets of label-free biosensing and the future trends in this flourishing field. Highlights of the subjects covered include label-free biosensing with: · semiconductor field-effect devices such as nanomaterial-modified capacitive electrolyte-insulator-semiconductor structures, silicon nanowire transistors, III-nitride semiconductor devices and light-addressable potentiometric sensors · impedimetric biosensors using planar and 3D electrodes · nanocavity and solid-state nanopore devices · carbon nanotube and graphene/graphene oxide biosensors · electrochemical biosensors using molecularly imprinted polymers · biomimetic sensors based on acoustic signal transduction · enzyme logic systems and digital biosensors based on the biocomputing concept · heat-transfer as a novel transducer principle · ultrasensitive surface plasmon resonance biosensors · magnetic biosensors and magnetic imaging devices
Biosensors Based on Nanomaterials and Nanodevices links interdisciplinary research from leading experts to provide graduate students, academics, researchers, and industry professionals alike with a comprehensive source for key advancements and future trends in nanostructured biosensor development. It describes the concepts, principles, materials, device fabrications, functions, system integrations, and applications of various types of biosensors based on signal transduction mechanisms, including fluorescence, photonic crystal, surface-enhanced Raman scattering, electrochemistry, electro-luminescence, field-effect transistor, and magnetic effect. The book: Explains how to utilize the unique properties of nanomaterials to construct nanostructured biosensors to achieve enhanced performance Features examples of biosensors based on both typical and emerging nanomaterials, such as gold nanoparticles, quantum dots, graphene, graphene oxides, magnetic nanoparticles, carbon nanotubes, inorganic nanowires/nanorods, plasmonic nanostructures, and photonic crystals Demonstrates the broad applications of nanostructured biosensors in environmental monitoring, food safety, industrial quality assurance, and in vitro and in vivo health diagnosis Inspires new ideas for tackling multiscale and multidisciplinary issues in developing high-performance biosensors for complex practical biomedical problems Focusing on the connection between nanomaterials research and biosensor development, Biosensors Based on Nanomaterials and Nanodevices illustrates the exciting possibilities and critical challenges of biosensors based on nanomaterials and nanodevices for future health monitoring, disease diagnosis, therapeutic treatments, and beyond.
This book presents recent developments in the field of biosensors and their applications in healthcare. Topics include aptasensors for the detection of environmental contaminants, disease-causing pathogens, molecularly imprinted polymers for the detection of genetic materials, infectious diseases, in vivo monitoring of key molecules, functional nanoparticles targeted to specific tumor cells for detection as well as imaging.
This book broadly reviews the modem techniques and significant applications of chemical sensors and biosensors. Chapters are written by experts in the field – including Professor Joseph Wang, the most cited scientist in the world and renowned expert on sensor science who is also co-editor. Each chapter provides technical details beyond the level found in typical journal articles, and explores the application of chemical sensors and biosensors to a significant problem in biomedical science, also providing a prospectus for the future.This book compiles the expert knowledge of many specialists in the construction and use of chemical sensors and biosensors including nitric oxide sensors, glucose sensors, DNA sensors, hydrogen sulfide sensors, oxygen sensors, superoxide sensors, immuno sensors, lab on chip, implatable microsensors, et al. Emphasis is laid on practical problems, ranging from chemical application to biomedical monitoring and from in vitro to in vivo, from single cell to animal to human measurement. This provides the unique opportunity of exchanging and combining the expertise of otherwise apparently unrelated disciplines of chemistry, biological engineering, and electronic engineering, medical, physiological. - Provides user-oriented guidelines for the proper choice and application of new chemical sensors and biosensors - Details new methodological advancements related to and correlated with the measurement of interested species in biomedical samples - Contains many case studies to illustrate the range of application and importance of the chemical sensors and biosensors
Containing cutting edge research on the hot topic of nanobiosensor, this book will become highly read Biosensor research has recently re-emerged as most vibrant area in recent years particularly after the advent of novel nanomaterials of multidimensional features and compositions. Nanomaterials of different types and striking properties have played a positive role in giving the boost and accelerated pace to biosensors development technology. Nanobiosensors - From Design to Applications covers several aspects of biosensors beginning from the basic concepts to advanced level research. It will help to bridge the gap between various aspects of biosensors development technology and applications. It covers biosensors related material in broad spectrum such as basic concepts, biosensors & their classification, biomarkers & their role in biosensors, nanostructures-based biosensors, applications of biosensors in human diseases, drug detection, toxins, and smart phone based biosensors. Nanobiosensors - From Design to Applications will prove a source of inspiration for research on biosensors, their local level development and consequently using for practical application in different industries such as food, biomedical diagnosis, pharmaceutics, agriculture, drug discovery, forensics, etc. * Discusses the latest technology and advances in the field of nanobiosensors and their applications in human diseases, drug detection, toxins * Offers a broad and comprehensive view of cutting-edge research on advanced materials such as carbon materials, nitride based nanomaterials, metal and metal oxide based nanomaterials for the fast-developing nanobiosensors research * Goes to a wide scientific and industry audience Nanobiosensors - From Design to Applications is a resource for polymer chemists, spectroscopists, materials scientists, physical chemists, surface chemists, and surface physicists.
A biosensor is a detecting device that combines a transducer with a biologically sensitive and selective component. Biosensors can measure compounds present in the environment, chemical processes, food and human body at low cost if compared with traditional analytical techniques. This book covers a wide range of aspects and issues related to biosensor technology, bringing together researchers from 19 different countries. The book consists of 27 chapters written by 106 authors and divided in three sections: Biosensors Technology and Materials, Biosensors for Health and Biosensors for Environment and Biosecurity.