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Detection and Analysis of SARS Coronavirus Detecting and analyzing the COVID-19 pandemic with biosensor technology The highly contagious SARS CoV-2 pathogen has challenged health systems around the world as they struggle to detect and monitor the spread of the pathogen. In Detection and Analysis of SARS Coronavirus: Advanced Biosensors for Pandemic Viruses and Related Pathogens expert chemists Chaudhery Mustansar Hussain and Sudheesh K. Shukla deliver a practical analysis of how contactless coronavirus detectors may be developed using existing biosensor technology. The editors outline current challenges in the field, the bioanalytical principles for coronavirus detection, and available biosensor technology. They then move on to how available technology might be adapted to detect coronaviruses and how commercialization of the technology might unfold. The lessons learned in this book are readily applicable to the study of other current and emerging pathogens. Readers will also enjoy: A thorough introduction to the current diagnostic approaches for COVID-19, including common challenges, technology adaptation, and future potential An exploration of bio-analytical strategies for SARS CoV-2/COVID-19, including COVID detection via nanotechnology, biosensing approaches, and the role of nanotechnology in coronavirus detection Practical discussions of biosensors for the analysis of SARS CoV-2/COVID-19, including sensor development for coronavirus and chemical sensors for coronavirus diagnosis In-depth treatments of the commercialization and standardization for analytical technologies Perfect for virologists, pharmaceutical industry professionals, and sensor developers, Detection and Analysis of SARS Coronavirus is also an indispensable resource for those working in analytical research institutes, biotechnology industry professionals, and public health agency professionals.
In this issue of Clinics in Laboratory Medicine, guest editors Drs. Daimon P. Simmons and Peter H. Schur bring their considerable expertise to the topic of Detection of SARS-CoV-2 Antibodies in Diagnosis and Treatment of COVID-19. Top experts in the field cover key topics such as performance of central lab assays to detect SARS-COV-2 antibodies; alternative methods to detect SARS-CoV-2 antibodies; the role of antibodies in developing vaccines for COVID-19; SARS-COV-2 antibodies after immunization; and more. Contains 9 relevant, practice-oriented topics including disease-specific alterations in the cellular bases of the humoral immune response in COVID-19; coronavirus antigens as targets of antibody responses; approaches for SARS-CoV-2 antibody testing in a reference lab; use of IgM, IgA, and IgG in treatment and prognosis of patients with COVID-19; performance of lateral flow assays for COVID-19 serology; and more. Provides in-depth clinical reviews on detection of SARS-CoV-2 antibodies in diagnosis and treatment of COVID-19, offering actionable insights for clinical practice. Presents the latest information on this timely, focused topic under the leadership of experienced editors in the field. Authors synthesize and distill the latest research and practice guidelines to create clinically significant, topic-based reviews.
This book describes an adaptable biothreat assessment process to complement overall biorisk management programs, incorporating threat management and the unique natures of biological assets. Further, this book examines the nexus between public health, international security, and developing technologies, building a case for augmenting biosecurity to levels beyond the laboratory constraints. With the face of biological and biomedical sciences changing, this book describes how with proper biosecurity development, these can become assets, rather than liabilities, to secure our world from natural and man-made biological disasters. The world is changing rapidly with respect to developing threats, such as terrorism, and dual-use technologies, such as synthetic biology, that are challenging how we think about biosafety and biosecurity. Further, the fields of public health and international security are colliding, as both of these share the common enemy: intentional or natural biological incidents. To date, biosecurity has been limited to laboratory-level application, and complicating efforts, and lacks credentialed biosecurity professionals skilled in both the biological sciences and threat management techniques. The result is a fragmented field of practice, with tremendous need, from the lab to the outbreak. Underpinning these principles is the SARS-CoV-2 coronavirus pandemic, providing a historic milestone to examine biosecurity through a global lens. This book describes biosecurity as a set of practices and principles to be augmented out of the constrained laboratory environment, and applied to larger efforts, such as international threat reduction and biological incident management.
There are many guidelines, protocols and advisories that outline how biosafety and biosecurity can be adopted by institutions around the world. Whilst helpful, many of these are tailored to affluent Western nations. This leaves developing nations far behind since their laboratories and institutions are resource-scarce and biosafety and biosecurity are not mainstreamed entirely among the different laboratory workers, healthcare professionals, researchers, and academics. Biosafety and Biosecurity: Practical Insights and Applications for Low and Middle-Income Countries aims to bridge this gap by comprehensively summarizing the state and development of biosafety and biosecurity in developing and developed nations in a comparative analysis. This book includes basic concepts and principles of biosafety and biosecurity, including certification and legal frameworks, both international and local, and biosafety and biosecurity across disciplines including environmental, medical, and special topics that are relevant to countries with comparable conditions. This proposed book solves the problem of the lack of a prescribed professional title that comprehensively summarizes the state and development of biosafety and biosecurity throughout the world, allowing the reader a 360 view of the subject area. This book will appeal to a global audience of biorisk officers, health and safety professionals and specialists in the life sciences, health and allied fields, environmental science, engineering, and plant and animal agriculture.
In this issue of Clinics in Laboratory Medicine, guest editors Drs. Daimon P. Simmons and Peter H. Schur bring their considerable expertise to the topic of Detection of SARS-CoV-2 Antibodies in Diagnosis and Treatment of COVID-19. Top experts in the field cover key topics such as performance of central lab assays to detect SARS-COV-2 antibodies; alternative methods to detect SARS-CoV-2 antibodies; the role of antibodies in developing vaccines for COVID-19; SARS-COV-2 antibodies after immunization; and more. Contains 9 relevant, practice-oriented topics including disease-specific alterations in the cellular bases of the humoral immune response in COVID-19; coronavirus antigens as targets of antibody responses; approaches for SARS-CoV-2 antibody testing in a reference lab; use of IgM, IgA, and IgG in treatment and prognosis of patients with COVID-19; performance of lateral flow assays for COVID-19 serology; and more. Provides in-depth clinical reviews on detection of SARS-CoV-2 antibodies in diagnosis and treatment of COVID-19, offering actionable insights for clinical practice. Presents the latest information on this timely, focused topic under the leadership of experienced editors in the field. Authors synthesize and distill the latest research and practice guidelines to create clinically significant, topic-based reviews.
Abstract: Indoor event locations are particularly affected by the SARS-CoV-2 pandemic. At large venues, only incomplete risk assessments exist, whereby no suitable measures can be derived. In this study, a physical and data-driven statistical model for a comprehensive infection risk assessment has been developed. At venues displacement ventilation concepts are often implemented. Here simplified theoretical assumptions fail for the prediction of relevant airflows for airborne transmission processes. Thus, with locally resolving trace gas measurements infection risks are computed more detailed. Coupled with epidemiological data such as incidences, vaccination rates, test sensitivities, and audience characteristics such as masks and age distribution, predictions of new infections (mean), situational R-values (mean), and individual risks on- and off-seat can be achieved for the first time. Using the Stuttgart State Opera as an example, the functioning of the model and its plausibility are tested and a sensitivity analysis is performed with regard to masks and tests. Besides a reference scenario on 2022-11-29, a maximum safety scenario with an obligation of FFP2 masks and rapid antigen tests as well as a minimum safety scenario without masks and tests are investigated. For these scenarios the new infections (mean) are 10.6, 0.25 and 13.0, respectively. The situational R-values (mean) - number of new infections caused by a single infectious person in a certain situation - are 2.75, 0.32 and 3.39, respectively. Besides these results a clustered consideration divided by age, masks and whether infections occur on-seat or off-seat are presented. In conclusion this provides an instrument that can enable policymakers and operators to take appropriate measures to control pandemics despite ongoing mass gathering events
This is the third edition of this manual which contains updated practical guidance on biosafety techniques in laboratories at all levels. It is organised into nine sections and issues covered include: microbiological risk assessment; lab design and facilities; biosecurity concepts; safety equipment; contingency planning; disinfection and sterilisation; the transport of infectious substances; biosafety and the safe use of recombinant DNA technology; chemical, fire and electrical safety aspects; safety organisation and training programmes; and the safety checklist.
This detailed volume provides the increasing number of SARS-CoV-2 researchers with a useful handbook covering multidisciplinary approaches on various aspects of SARS-CoV-2 research, brought together by leading laboratories across the globe. Topics covered include techniques in clinical and diagnostic virology, basic protocols in cell and virus culture, as well as bioinformatics and proteomics approaches in cellular response studies. This comprehensive collection also covers methods in immunology, animal models, antivirals and vaccine development strategies, as well as biorisk and mitigation measurements for SARS-CoV-2 research. Written for the highly successful Methods in Molecular Biology series, chapters include the kind of detailed implementation advice that is vital for success in the lab. Practical and timely, SARS-CoV-2: Methods and Protocols serves as an ideal guide for scientists investigating this prevalent and perilous RNA virus and the novel coronavirus disease that results from it.
A novel coronavirus of zoonotic origin (SARS-CoV-2) has recently been recognized in patients with acute respiratory disease. COVID-19 causative agent is structurally and genetically similar to SARS and bat SARS-like coronaviruses. The drastic increase in the number of coronavirus and its genome sequence has given us an unprecedented opportunity to perform bioinformatics and genomics analysis on this class of viruses. Clinical tests such as PCR and ELISA for rapid detection of this virus are urgently needed for early identification of infected patients. However, these techniques are expensive and not readily available for point-of-care (POC) applications. Currently, lack of any rapid, available, and reliable POC detection method gives rise to the progression of COVID-19 as a horrible global problem. To solve the negative features of clinical investigation, we provide a brief introduction of the various novel diagnostics methods including SERS, SPR, electrochemical, magnetic detection of SARS-CoV-2. All sensing and biosensing methods based on nanotechnology developed for the determination of various classes of coronaviruses are useful to recognize the newly immerged coronavirus, i.e., SARS-CoV-2. Also, the introduction of sensing and biosensing methods sheds light on the way of designing a proper screening system.