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Part of the highly regarded Biopsy Interpretation Series, this new volume by Drs. Laura M. Wake, Genevieve Crane, and Michael Borowitz presents a concise, pattern-based approach to bone marrow pathology. Biopsy Interpretation of the Bone Marrow provides superbly illustrated guidance from top experts in the field, covering all aspects of bone marrow aspirates and biopsies: procurement and processing, ancillary techniques, formulation of a final diagnosis, and reporting to the clinical team. Hundreds of full-color illustrations depict the full range of benign and neoplastic processes involving the bone marrow.
This comprehensive, superbly illustrated reference is designed to provide practical diagnostic assistance for hematopathologists when dealing with common and uncommon lesions in bone marrow trephine biopsies (BMTBs). At the heart of the book is a systematic analysis of neoplastic hematological and non-hematological disease entities, with concise identification of the key features of myeloproliferative neoplasms, myelodysplastic syndromes, acute and chronic leukemias, eosinophilia-associated myeloid/lymphoid neoplasms, lymphoproliferative disorders, and selected non-hematopoietic malignancies. Relevant examples of BMTBs are presented, with microscopic description, high-quality photomicrographs, and clinical data. The book also explains how to assess hematopoietic and stromal components of normal BMTBs, identifies the heterogeneous patterns that may be observed in healthy individuals, and analyzes reactive conditions, with particular attention to diagnostic problems and pitfalls.
The clinical interpretation of bone and bone marrow biopsies contributes valuable information to the diagnostic puzzle in patients under investigation in a wide range of contexts from haematology and internal medicine, to orthopaedics, rheumatology and oncology. This fully revised and updated second edition of 'Biopsy Interpretation of Bone and Bone Marrow' builds on the features of its successful predecessor with high-quality photomicrographs, descriptive text and key references. The authors of this comprehensive and practical book ably demonstrate the scope and importance of biopsy interpretation in their field of expertise. This edition also has a number of new features:
This text illustrates bone marrow aspirate, imprint and biopsy specimens showing characteristic features of a wide variety of neoplastic and non-neoplastic conditions. While the focus is on Wright-stained smears and hematoxylin-eosin stained biopsies, other key histochemical and immunohistochemical stains are illustrated that are vital for proper diagnosis. After a brief review of the normal bone marrow, reactive changes in the marrow are illustrated, including the bone marrow response in constitutional disorders and to metabolic changes throughout the body. This is followed by specific infectious disorders in the marrow and other non-neoplastic disorders. The remainder of the Atlas illustrates the various neoplasms that involve the bone marrow, including leukemias, lymphomas and non-hematopoietic neoplasms. The hematologic neoplasms are classified using the 2016 World Health Organization (WHO) classification. This overview of bone marrow disorders illustrates a wide variety of diseases that practicing pathologists and hematologists will encounter in their routine practice.​
This book provides a highly illustrated and comprehensive account of the diseases of the human bone marrow. It will help experienced clinicians and those in training to answer the practical diagnostic questions that arise during the routine analysis of bone marrow core biopsy specimens. Throughout the text, histologic interpretation is integrated with clinical and laboratory findings. Emphasis is placed on the evaluation of peripheral blood, aspirate smear, clot section and core biopsy, as well as ancillary techniques including flow cytometry and immunohistochemistry in the diagnosis of hematologic disorders of the marrow. The text is illustrated with numerous color figures, charts and tables, and descriptions of real case situations using the most up-to-date classification systems. Illustrated Pathology of Bone Marrow should be read by all pathologists, hematologists and laboratory technicians involved in the analysis of bone marrow specimens.
This new volume of the Biopsy Interpretation Series is a practical, superbly illustrated reference on the primary non-lymphoid neoplasms of the skin. The book offers guidelines on how and when to biopsy the skin and then discusses benign melanocytic proliferations, precursor lesions to melanoma, and melanomas. Also included are discussions of basal cell carcinoma, squamous cell carcinoma and its precursors, benign and malignant adnexal neoplasms, and soft tissue neoplasms of the skin and superficial subcutis. A major highlight of the book is the extensive discussion of differential diagnostic considerations and their separation from the main diagnostic entities under consideration. The book features nearly 300 full-color images. A companion Website will provide 400 additional figures, plus a test bank that is ideal for board exam preparation.
Biopsy Interpretation of the Liver, Second Edition offers pathologists clear, practical guidelines for recognizing and diagnosing the full spectrum of liver disorders. Coverage begins with the basics—including technical considerations, liver anatomy, and examination methods—and progresses to specific disorders, with particular emphasis on histopathology. This completely updated Second Edition includes new material on transplantation pathology and new chapters on immunopathology and molecular pathology of liver diseases. A companion Website will provide the fully searchable text, over 700 additional full-color images of common and rare entities, and a test bank that is ideal for board exam preparation.
The microscopic examination of fossilized bone tissue is a sophisticated and increasingly important analytical tool for understanding the life history of ancient organisms. This book provides an essential primer and manual for using fossil bone histology to investigate the biology of extinct tetrapods. Twelve experts summarize advances in the field over the past three decades, reviewing fundamental basics of bone microanatomy and physiology. Research specimen selection, thin-section preparation, and data analysis are addressed in detail. The authors also outline methods and issues in bone growth rate calculation and chronological age determination, as well as how to examine broader questions of behavior, ecology, and evolution by studying the microstructure of bone.