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Defines the basic concepts from biology, mathematics, physics and chemistry that are needed to understand how excitable cells function. Applies them specifically to the study of membrane transport, artificial membranes, signal capturing and analysis in biological systems.
The fourth edition of this highly successful text has been extensively revised and restructured to take account of the many recent advances in the subject and bring it right up to date. The classic observations of recent years can now be interpreted with the powerful new techniques of molecular biology. Consequently there is much new material throughout the book, including many new illustrations and extensive references to recent work. Its essential philosophy remains the same, though: fundamental concepts are clearly explained, and key experiments are examined in some detail. This textbook will be used by students of physiology, neuroscience, cell biology and biophysics. Specializing undergraduates and graduates as well as lecturers and researchers will find the text thorough and clearly written.
The Russian edition of this book appeared in 1969 and im mediately gained widespread recognition as a reference work for research workers interested in the physiology, biophysics, and pharmacology of excitable tissues. There are several reasons for the book's success. It deals with a key problem in biology which has recently been the subject of very intensive study and it is of great interest to a wide scientific audience. Not only the fundamentals of the modern membrane theory of biopotentials, but also the vast factual material collected in the last decades by the study of the biophysical and pharmacological properties of the ionic permeability pores of the cell membrane, are described in the book in an authoritative yet readable form. Special attention is paid in the book to the systematic analysis of the consequences of the Hodgkin-Huxley mathematical theory of the nervous impulse for the problem of excitability. The relationship between the various parameters of excitability (threshold potential, threshold current, useful time), accommodation, and the action potential on the one hand, and the constants of ionic permeability of the nerve fiber membrane, on the other hand, is subjected to detailed examination in this context. To do this, the author has made extensive use not only of experimental results obtained on isolated fibers (especially single nodes of Ran vier), but also the results of his own investigations on mathematical models of excitable membranes.
On July 10, 1980, Kenneth S. Cole became 80 years old. In order to celebrate this landmark, a symposium in the form of a series of Monday evening lectures was held in his honor at the Marine Biological Labora tory throughout the summer of 1980. The selection of speakers was made from among those investigators who had been either his students or co-workers. One intent of the symposium was to examine the current status of knowledge of those areas of interest in excitable membrane structure and function that owe their initiation or encouragement to Kacy Cole. The papers assembled in this volume represent a large majority of the presentations given during the 1980 Cole Symposium. It seems clear on examination of these papers that Kacy's interests in membrane impedance, ion channel conductances, channel fluctuation phenomena, excitation, and the development of membrane biophysical methodology are all being actively pursued. It is also clear that many of his suggestions have borne fruit. Of these, his invention of the voltage v vi Preface clamp method has been most productive. It is hoped that these papers will provide new directions for investigations into the nature of excitable membrane phenomena. The organizers of the symposium and the editors of this volume wish to express their thanks to the Marine Biological Laboratory for making available the facilities for the symposium. They also wish to thank Dr.
Voltage-sensitive ion channels are macromolecules embedded in the membranes of nerve and muscle fibers of animals. Despite decades of intensive research under the traditional approach of gated structural pores, the relation between the structure of these molecules and their function remains enigmatic. This book examines physically oriented approaches not covered in other ion-channel books, and it develops a new physics-based approach to the problem of molecular excitability.
Physiology of Excitable Membranes contains plenary lecture and most of the papers presented at five symposia of the Section ""General Cell Physiology"" at the 28th International Congress of Physiological Sciences. Organized into 44 chapters, this book begins with a discussion on the ionic mechanisms of excitability of nerve cells. Subsequent chapters focus on charge movement in nerve membrane; calcium electrogenesis; optical changes during electrogenesis; synaptic transmission and modulation; and transmission in autonomic ganglia.
X-ray analysis of nerve myelin. The thermodynamic foundations of membrane physiology. Ion transport across excitable cell membranes. Some aspects of electrical studies of the squid giant axon membrane. Voltage clamp methods. Description of axon membrane ionic conductances and currents. Digital computer solutions of membrane currents in the voltage clamped axon. Varying potential control voltage clamp of axons. Analysis and reconstruction of axon membrane action potential. Digital computer reconstruction of axon membrane action potential. Analysis and reconstruction of propagated impulse in the squid giant axon. Voltage clamp studies on myelinated nerve fibers. Optical studies of action potentials. Internal perfusion of squid axons: technical considerations. Electrical studies of internally perfused squid axons. The effect of temperature on the function of excitable membranes. Excitability models. Fixed surface charges. Ion exchange properties and excitability of the squid giant axon. Neurophysiological basis for drug action: ionic mechanism, site of action and active form in nerve fibers. Excitability in lipid bilayer membranes. The varieties of excitable membranes.
This new, fully revised and expanded edition of Ionic Channels of Excitable Membranes includes new chapters on fast chemical synapses, modulation through G protein coupled receptors and second messenger systems, molecules cloning, site directed mutagenesis, and cell biology. It begins with the classical biophysical work of Hodgkin and Huxley and then weaves a description of the known ionic channels together with their biological functions. The book continues by developing the physical and molecular principles needed for explaining permeation, gating, pharmacological modification, and molecular diversity, and ends with a discussion of channel evolution. Ionic Channels of Excitable Membranes is written to be accessible and interesting to biological and physical scientists of all kinds.