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This book focusses on the development of biomedical membranes and their applications for (bio)artificial organs. It covers the state of art and main challenges for applying synthetic membranes in these organs. It also highlights the importance of accomplishing an integration of engineering with biology and medicine to understand and manage the scientific, industrial, clinical and ethical aspects of these organs.The compendium consists of 11 chapters, written by world renowned experts in the fields of membrane technology, biomaterials science and technology, cell biology, medicine and engineering. Every chapter describes the clinical needs and the materials, membranes, and concepts required for the successful development of the (bio)artificial organs.This text is suitable for undergraduate and graduate students in biomedical engineering, materials science and membrane science and technology, as well as, for professionals and researchers working in these fields.
Membrane processes today play a signifi cant role in the replacement therapy for acute and chronic organ failure diseases. Current extracorporeal blood purifi cation and oxygenation devices employ membranes acting as selective barriers for the removal of endogeneous and exogeneous toxins and for gas exchange, respectively. Additionally, membrane technology offers new interesting opportunities for the design of bioartificial livers, pancreas, kidneys, lungs etc. This book reviews the latest developments in membrane systems for bioartificial organs and regenerative medicine, investigates how membrane technology can improve the quality and efficiency of biomedical devices, and highlights the design procedures for membrane materials covering the preparation, characterization, and sterilization steps as well as transport phenomena. The different strategies pursued for the development of membrane bioartifi cial organs, including crucial issues related to blood/cell-membrane interactions are described with the aim of opening new and exciting frontiers in the coming decades. The book is a valuable tool for tissue engineers, clinicians, biomaterials scientists, membranologists as well as biologists and biotechnologists. It is also a source of reference for students, academic and industrial researchers in the topic of biotechnology, biomedical engineering, materials science and medicine.
Current Trends and Future Developments on (Bio-) Membranes: Membrane Applications in Artificial Organs and Tissue Engineering reports on membrane applications in the field of biomedical engineering, ranging from artificial organs, to tissue engineering. The book offers a comprehensive review of all the current scientific developments and various applications of membranes in this area. It is a key reference text for R&D managers in industry who are interested in the development of artificial and bioartificial organs, as well as academic researchers and postgraduate students working in the wider area of artificial organs and tissue engineering. Describes numerous bioartificial organ configurations and their relationships to membranes Includes new innovations and solutions in the development of artificial organs with membrane components Describes various membrane fabrication techniques for tissue engineering
In tissue engineering the formation of organized and functional tissues is a very complex task: the cellular environment requires suitable physiological conditions that, presently, can be achieved and maintained by using properly designed biomaterials that can support the viability and all specific functions of cells. The creation of the biomimetic environment can be realized by using polymeric membranes with specific physico-chemical, morphological, and transport properties on the basis of the targeted tissue or organ. Membrane can act as an instructive extracellular matrix (ECM) for cells, especially for stem cells or progenitor cells, whose differentiation is desired for their therapeutic potential and usefulness in the toxicological testing. Similar to the ECM, membrane exhibits from microscale to nanoscale of chemistry and topography and is able to provide physical, chemical, and mechanical signals to the cells, which are important for guiding their differentiation. In this chapter, the authors report on tailor-made membrane systems designed and operated according to well-defined engineering criteria and their potential use in the biofabrication of tissues and organs. Membrane surface and transport properties play a pivotal role in the proliferation and differentiation process governing mass transfer and providing instructive signals to the cells. Furthermore, membrane bioreactors, through the fluid dynamics modulation, may simulate the in vivo complex physiological environment, ensuring an adequate mass transfer of nutrients and metabolites and the molecular and mechanical regulatory signals.
This is the first time that human organs, such as the heart, liver, kidney, stomach, uterus, skin, lung, pancreas and breast can be manufactured automatically and precisely for clinical transplantation, drug screening and metabolism model establishment. Headed by Professor Xiaohong Wang (also the founder and director) in the Center of Organ Manufacturing, Department of Mechanical Engineering, Tsinghua University, this group has focused on organ manufacturing for over ten years. A series of technical bottleneck problems, such as vascular and nerve system establishment in a construct, multiple cell types and material system incorporation, and stem cell sequential engagement, have been overcome one by one. Two technical approaches have been exploited extensively. One is multiple nozzle rapid prototyping (RP), additive manufacturing (AM), or three-dimension (3D) printing. The other is combined mold systems. More than 110 articles and 40 patents with a series of theories and practices have been published consequently. In the future, all the failed organs (including the brain) in the human body can be substituted easily like a small accessory part in a car. Everyone can get benefit from these techniques, which ultimately means that the lifespan of humans, therefore, can be greatly prolonged from this time point. This book examines the progress made in the field and the developments made by these researchers (and authors) in the field.
An important resource that puts the focus on the chemical engineering aspects of biomedical engineering In the past 50 years remarkable achievements have been advanced in the fields of biomedical and chemical engineering. With contributions from leading chemical engineers, Biomedical Engineering Challenges reviews the recent research and discovery that sits at the interface of engineering and biology. The authors explore the principles and practices that are applied to the ever-expanding array of such new areas as gene-therapy delivery, biosensor design, and the development of improved therapeutic compounds, imaging agents, and drug delivery vehicles. Filled with illustrative case studies, this important resource examines such important work as methods of growing human cells and tissues outside the body in order to repair or replace damaged tissues. In addition, the text covers a range of topics including the challenges faced with developing artificial lungs, kidneys, and livers; advances in 3D cell culture systems; and chemical reaction methodologies for biomedical imagining analysis. This vital resource: Covers interdisciplinary research at the interface between chemical engineering, biology, and chemistry Provides a series of valuable case studies describing current themes in biomedical engineering Explores chemical engineering principles such as mass transfer, bioreactor technologies as applied to problems such as cell culture, tissue engineering, and biomedical imaging Written from the point of view of chemical engineers, this authoritative guide offers a broad-ranging but concise overview of research at the interface of chemical engineering and biology.
A wide variety of materials is being used in biomedical engineering for various functions. This includes a range of ceramics, polymers and metallic materials for implants and medical devices. A major question is how these materials will perform inside the body, which is very sensitive to alien materials.
This concise and systematically organized text, now in its second edition, gives a clear insight into various membrane separation processes. It covers the fundamentals as well as the recent developments of different processes along with their industrial applications and the products. It includes the basic principles, operating parameters, membrane hardware, flux equation, transport mechanism, and applications of membrane-based technologies. Membrane separation processes are largely rate-controlled separations which require rate analysis for complete understanding. Moreover, a higher level of mathematical analysis, along with the understanding of mass transfer, is also required. These are amply treated in different chapters of the book to make the students comprehend the membrane separation principles with ease. This textbook is primarily designed for undergraduate students of chemical engineering, biochemical engineering and biotechnology for the course in membrane separation processes. Besides, the book will also be useful to process engineers and researchers. KEY FEATURES • Provides sufficient number of examples of industrial applications related to chemical, metallurgical, biochemical and food processing industries. • Focuses on important biomedical applications of membrane-based technologies such as blood oxygenator, controlled drug delivery, plasmapheresis, and bioartificial organs. • Includes chapter-end short questions and problems to test students’ comprehension of the subject. NEW TO THIS EDITION • A new section on membrane cleaning is included. Membrane fabrication methods are supplemented with additional information (Chapter 2). • Additional information on silt density index, forward osmosis and sea water desalination (Chapter 3). • Physicochemical parameters affecting nanofiltration, determination of various resistances using resistance in series model and few more industrial applications with additional short questions (Chapter 4). • Membrane cross-linking methods used in pervaporation, factors affecting pervaporation and few more applications (Chapter 9). • Membrane distillation, membrane reactor with different modules, types of membranes and reactions for membrane reactor (Chapter 13).
Despite a large number of books related to membrane technology and membrane processes, books specifically intended for and focused on fibers used in membrane applications are still lacking. Since the development of the first modules, hollow fibers have totally revolutionized the world of membranes--thanks to the new technological breakthroughs and innovative materials discovered. The importance of a book putting hollow fibers in the spotlight owes to this type of configuration being more and more appreciated, particularly in large-scale applications. Moreover, the advent of nanofibers has injected new vitality in biomedical research, in air and water separation and filtration processes, and in the emerging areas of nanotechnology. This book singles out and highlights the unique properties that hollow fibers and nanofibers display both in the fields where they already represent the dominant configuration and in the areas where their full exploitation is still hindered by economic and technological constraints.