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This third edition of the biomedical optics classic Tissue Optics covers the continued intensive growth in tissue optics—in particular, the field of tissue diagnostics and imaging—that has occurred since 2007. As in the first two editions, Part I describes fundamentals and basic research, and Part II presents instrumentation and medical applications. However, for the reader’s convenience, this third edition has been reorganized into 14 chapters instead of 9. The chapters covering optical coherence tomography, digital holography and interferometry, controlling optical properties of tissues, nonlinear spectroscopy, and imaging have all been substantially updated. The book is intended for researchers, teachers, and graduate and undergraduate students specializing in the physics of living systems, biomedical optics and biophotonics, laser biophysics, and applications of lasers in biomedicine. It can also be used as a textbook for courses in medical physics, medical engineering, and medical biology.
Several previous Advanced Study Institutes have concentrated on the techniques of light scattering, while the biological appli cations were not fully explored. Many of the techniques are now standardised and are being applied to a wide range of biologically significant problems both in vivo and in vitro. While laser light scattering methods are superior to conventional methods, there was a general reluctance among biologists to adopt them because of the complexity of the physical techniques and the accompanying mathe matical analysis. Consequently valuable opportunities for advancing the understanding of the biological problems were being missed. Advances in the design and commercial availability of standard light scattering instruments, and the availability of standard computer programs, made the more widespread use of these techniques a practical reality for the biologist. While biologists are unable to cope with the complexities of the physical techniques, physicists are generally unaware of the nature and scale of the biological problems. The meeting at Maratea was an attempt to bring these two groups together and provide an impetus for the application of laser light scattering techniques to biology. This volume differs from the three previous proceedings on laser light scattering in the NATO ASI series (B3, B23, B73), in that it has been published in the Life Sciences series rather than the Physics series, reflecting the shift in emphasis from the development of a new technique to its application in biology.
Optical Polarization in Biomedical Applications introduces key developments in optical polarization methods for quantitative studies of tissues, while presenting the theory of polarization transfer in a random medium as a basis for the quantitative description of polarized light interaction with tissues. This theory uses the modified transfer equation for Stokes parameters and predicts the polarization structure of multiple scattered optical fields. The backscattering polarization matrices (Jones matrix and Mueller matrix) important for noninvasive medical diagnostic are introduced. The text also describes a number of diagnostic techniques such as CW polarization imaging and spectroscopy, polarization microscopy and cytometry. As a new tool for medical diagnosis, optical coherent polarization tomography is analyzed. The monograph also covers a range of biomedical applications, among them cataract and glaucoma diagnostics, glucose sensing, and the detection of bacteria.
Geared toward upper-level undergraduate and graduate students, this text introduces the interdisciplinary area of laser light scattering. It focuses chiefly on quasielastic laser scattering, discussing theoretical concepts at a realistic level. Some background in the physical sciences is assumed, but the opening chapters offer a brief review of classical electricity and magnetism as well as the general scattering theory. Topics include basic theoretical concepts related to light mixing spectroscopy, characteristics of the Fabry-Perot interferometer, and photon-counting fluctuations. The author, a distinguished professor in the Department of Chemistry at Stony Brook University, discusses experimental methods, including setting up a light scattering spectrometer using digital photon-counting and correlation techniques. Subsequent chapters explore applications to macromolecular systems, anemometry and its utility in reaction kinetics, and critical opalescence. References appear throughout the text.
This text begins by describing the basic principles and diagnostic applications of optical techniques based on detecting and processing the scattering, fluorescence, FT IR, and Raman spectroscopic signals from various tissues, with an emphasis on blood, epithelial tissues, and human skin. The second half of the volume discusses specific imaging technologies, such as Doppler, laser speckle, optical coherence tomography (OCT), and fluorescence and photoacoustic imaging.
The papers in this volume cover the major areas of research activity in the field of ultrafast optics at the present time, and they have been selected to provide an overview of the current state of the art. The purview of the field is the methods for the generation, amplification, and characterization of electromagnetic pulses with durations from the pieo-to the attosecond range, as well as the technical issues surrounding the application of these pulses in physics, chemistry, and biology. The contributions were solicited from the participants in the Ultrafast Optics IV Conference, held in Vienna, Austria, in June 2003. The purpose of the conference is similar to that of this book: to provide a forum for the latest advances in ultrafast optical technology. Ultrafast light sources provide a means to observe and manipulate events on the scale of atomic and molecular dynamics. This is possible either through appropriate shaping of the time-dependent electrie field, or through the ap plication of fields whose strength is comparable to the binding forces of the electrons in atoms and molecules. Recent advances discussed here include the generation of pulses shorter than two optical cycles, and the ability to measure and to shape them in all degrees of freedom with unprecedented 2 21 2 precision, and to amplify them to the Zettawatt/cm (10 W /cm ) range.
Lasers have a wide and growing range of applications in medicine. Lasers for Medical Applications summarises the wealth of recent research on the principles, technologies and application of lasers in diagnostics, therapy and surgery.Part one gives an overview of the use of lasers in medicine, key principles of lasers and radiation interactions with tissue. To understand the wide diversity and therefore the large possible choice of these devices for a specific diagnosis or treatment, the respective types of the laser (solid state, gas, dye, and semiconductor) are reviewed in part two. Part three describes diagnostic laser methods, for example optical coherence tomography, spectroscopy, optical biopsy, and time-resolved fluorescence polarization spectroscopy. Those methods help doctors to refine the scope of involvement of the particular body part or, for example, to specify the extent of a tumor. Part four concentrates on the therapeutic applications of laser radiation in particular branches of medicine, including ophthalmology, dermatology, cardiology, urology, gynecology, otorhinolaryngology (ORL), neurology, dentistry, orthopaedic surgery and cancer therapy, as well as laser coatings of implants. The final chapter includes the safety precautions with which the staff working with laser instruments must be familiar.With its distinguished editor and international team of contributors, this important book summarizes international achievements in the field of laser applications in medicine in the past 50 years. It provides a valuable contribution to laser medicine by outstanding experts in medicine and engineering. - Describes the interaction of laser light with tissue - Reviews every type of laser used in medicine: solid state, gas, dye and semiconductor - Describes the use of lasers for diagnostics
A careful review of the literature covering various aspects of applications of lasers in science and technology reveals that lasers are being applied very widely throughout the entire gamut of physical medicine. After surveying the current developments taking place in the field of medical applications of lasers, it was considered appropriate to bring together these efforts of international research scientists and experts into one volume. It is with this aim that the editors have prepared this volume which brings current research and recent developments to the attention of a wide spectrum of readership associated with hospitals, medical institutions and universities world wide, including also the medical instrument industry. Both teachers and students in the medical faculties will especially find this compendium quite useful. This book is comprised of eleven chapters. All of the important medical applications of lasers are featured. The editors have made every effort that individual chapters are self-contained and written by experts. Emphasis has been placed on straight and simple presentation of the subject matter so that even the new entrants into the field will find the book of value.
The material in this book is based upon a two-day workshop on solid state physical sensors for biomedical applications held in Huron, Ohio, December 8-9, 1977. The individual sections of the book are based upon presentations made by the authors at the workshop. Each presentation was transcribed and given to the authors for revision. Also, transcribed, are the discussions had following each presentation.