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In-depth information on natural biomaterials and their applications for translational medicine! Undiluted expertise: edited by world-leading experts with contributions from top-notch international scientists, collating experience and cutting-edge knowledge on natural biomaterials from all over the world A must-have on the shelf in every biomaterials lab: graduate and PhD students beginning their career in biomaterials science and experienced researchers and practitioners alike will turn to this comprehensive reference in their daily work Link to clinical practice: chapters on translational research make readers aware of what needs to be considered when a biomaterial leaves the lab to be routinely used
This book provides comprehensive coverage of smart biomaterials and their potential applications, a field that is developing at a very rapid pace. Because smart biomaterials are an emerging class of biomaterials that respond to small changes in external stimuli with large discontinuous changes in their physical properties, they have been designed to act as an “on–off” switch for, among others, bio separation, immunoanalysis, drug delivery technologies, gene therapy, diagnostics, bio sensors and artificial muscles. After an introduction to the topic and the history of smart biomaterials, the author gives the reader an in-depth look at the properties, mechanics, and characterization of smart biomaterials including hydrogels, particles, assemblies, surfaces, fibers and conjugates. Information on the wide range of applications for these materials follows, including drug delivery, tissue engineering, diagnostics, biosensors, bio separation and actuators. In addition, recent advances in shape memory biomaterials as active components of medical devices are also presented.
Sustainable Seaweed Technologies: Cultivation, Biorefinery, and Applications collates key background information on efficient cultivation and biorefinery of seaweeds, combining underlying chemistry and methodology with industry experience. Beginning with a review of the opportunities for seaweed biorefinery and the varied components and properties of macroalgae, the book then reviews all the key steps needed for industrial applications, from its cultivation, collection and processing, to extraction techniques, concentration and purification. A range of important applications are then discussed, including the production of energy and novel materials from seaweed, before a set of illustrative case studies shows how these various stages work in practice. Drawing on the expert knowledge of a global team of editors and authors, this book is a practical resource for both researchers and businesses who currently work with macroalgae. - Highlights the specific challenges and benefits of developing seaweed for sustainable products - Presents useful case studies that demonstrate varied approaches and methodologies in practice - Covers the complete seaweed chain, from cultivation to waste management
Bioinspired Materials for Medical Applications examines the inspiration of natural materials and their interpretation as modern biomaterials. With a strong focus on therapeutic and diagnostic applications, the book also examines the development and manipulation of bioinspired materials in regenerative medicine. The first set of chapters is heavily focused on bioinspired solutions for the delivery of drugs and therapeutics that also offer information on the fundamentals of these materials. Chapters in part two concentrate on bioinspired materials for diagnosis applications with a wide coverage of sensor and imaging systems With a broad coverage of the applications of bioinspired biomaterials, this book is a valuable resource for biomaterials researchers, clinicians, and scientists in academia and industry, and all those who wish to broaden their knowledge in the allied field. - Explores how materials designed and produced with inspiration from nature can be used to enhance man-made biomaterials and medical devices - Brings together the two fields of biomaterials and bioinspired materials - Written by a world-class team of research scientists, engineers, and clinicians
This book is the second of two volumes that together offer a comprehensive account of cutting-edge advances in the development of biomaterials for use within tissue engineering and regenerative medicine. In this volume, which is devoted to biomimetic biomaterials, the opening section discusses bone regeneration by means of duck’s feet-derived collagen scaffold and the use of decellularized extracellular matrices. The role of various novel biomimetic hydrogels in regenerative medicine is then considered in detail. The third section focuses on the control of stem cell fate by biomimetic biomaterials, covering exosome-integrated biomaterials for bone regeneration, cellular responses to materials for biomedical engineering, and the regulation of stem cell functions by micropatterned structures. Finally, the use of nano-intelligent biocomposites in regenerative medicine is addressed, with discussion of, for example, recent advances in biphasic calcium phosphate bioceramics and blood-contacting polymeric biomaterials. The authors are recognized experts in the interdisciplinary field of regenerative medicine and the book will be of value for all with an interest in regenerative medicine based on biomaterials.
This book presents an introduction to biomaterials with the focus on the current development and future direction of biomaterials and medical devices research and development in Indonesia. It is the first biomaterials book written by selected academic and clinical experts experts on biomaterials and medical devices from various institutions and industries in Indonesia. It serves as a reference source for researchers starting new projects, for companies developing and marketing products and for governments setting new policies. Chapter one covers the fundamentals of biomaterials, types of biomaterials, their structures and properties and the relationship between them. Chapter two discusses unconventional processing of biomaterials including nano-hybrid organic-inorganic biomaterials. Chapter three addresses biocompatibility issues including in vitro cytotoxicity, genotoxicity, in vitro cell models, biocompatibility data and its related failure. Chapter four describes degradable biomaterial for medical implants, which include biodegradable polymers, biodegradable metals, degradation assessment techniques and future directions. Chapter five focuses on animal models for biomaterial research, ethics, care and use, implantation study and monitoring and studies on medical implants in animals in Indonesia. Chapter six covers biomimetic bioceramics, natural-based biocomposites and the latest research on natural-based biomaterials in Indonesia. Chapter seven describes recent advances in natural biomaterial from human and animal tissue, its processing and applications. Chapter eight discusses orthopedic applications of biomaterials focusing on most common problems in Indonesia, and surgical intervention and implants. Chapter nine describes biomaterials in dentistry and their development in Indonesia.
This new volume, Natural Polymers: Perspectives and Applications for a Green Approach, covers the synthesis, characterizations, and properties of natural polymeric systems, including their morphology, structure, and dynamics. It also introduces the most recent innovations and applications of natural polymers and their composites in the food, construction, electronics, biomedical, pharmaceutical, and engineering industries. Natural polymers provide a striking substitute for various applications as compared to synthetic polymers obtained from petrochemicals because they are biocompatible, biodegradable, easily available, and fall within the budget of many industries. The applications of natural polymers in pharmaceutical industries are large in comparison to synthetic polymers and are also wide in scope in the food and cosmetic industries. This new volume provides the information needed to design new applications for natural polymers. This book is a valuable reference for researchers, academicians, chemists, pharmacists, researchers, scientists, industrialists dealing with applications of natural polymers and people working in field of natural polymers.
Fiber and Textile Engineering in Drug Delivery Systems explains how innovative textile processing methods including rotary spinning, microfluidics, wet spinning and electrospinning can be used to produce novel drug delivery solutions. This topical book provides detailed descriptions of how to produce such new materials for this purpose, with foundational content to help readers from a range of backgrounds understand the context of material selection and design decisions. Emphasis is given to the engineering side of the manufacturing of the textile and its role in drug delivery, but this also acts as a guide to pharmaceutical applications of textile fibers for materials scientists. Drug delivery research is rapidly expanding and experimenting with new materials to drive improved clinical outcomes as the efficacy of the therapeutic molecule is highly dependent on the right choice of carrier system. Recently, fiber based carriers at both nano and micro scales are gaining interest in the scientific community due to ease of manufacturing, high surface area to volume ratio, desirable drug release kinetics and high mechanical strength. - Describes methods for material selection and design for drug delivery systems - Provides case studies to explain how these techniques can be applied successfully - Covers the regulatory and legal aspects of the use of the textiles and fibers in drug delivery
This book covers the properties of biomaterials that have found wide clinical applications, while also reviewing the state-of-the-art in the development towards future medical applications, starting with a brief introduction to the history of biomaterials used in hip arthroplasty. The book then reviews general types of biomaterials – polymers, ceramics, and metals, as well as different material structures such as porous materials and coatings and their applications – before exploring various current research trends, such as biodegradable and porous metals, shape memory alloys, bioactive biomaterials and coatings, and nanometals used in the diagnosis and therapy of cancer. In turn, the book discusses a range of methods and approaches used in connection with biomaterial properties and characterization – chemical properties, biocompatibility, in vivo behaviour characterisation, as well as genotoxicity and mutagenicity – and reviews various diagnostic techniques: histopathological analysis, imagining techniques, and methods for physicochemical and spectroscopic characterization. Properties of stent deployment procedures in cardiovascular surgeries, from aspects of prediction, development and deployment of stent geometries are presented on the basis of novel modelling approaches. The last part of the book presents the clinical applications of biomaterials, together with case studies in dentistry, knee and hip prosthesis. Reflecting the efforts of a multidisciplinary team of authors, gathering chemical engineers, medical doctors, physicists and engineers, it presents a rich blend of perspectives on the application of biomaterials in clinical practice. The book will provide clinicians with an essential review of currently available solutions in specific medical areas, also incorporating non-medical solutions and standpoints, thus offering them a broader selection of materials and implantable solutions. This work is the result of joint efforts of various academic and research institutions participating in WIMB Tempus project, 543898-TEMPUS-1-2013-1-ES-TEMPUS-JPHES, "Development of Sustainable Interrelations between Education, Research and Innovation at WBC Universities in Nanotechnologies and Advanced Materials where Innovation Means Business", co-funded by the Tempus Programme of the European Union.
This book provides understanding of raw materials, manufacturing and biomedical applications of different polymeric and natural composites such as drug delivery, growth factor delivery, orthopedics, dentistry and wound dressing.