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Biological Oxidation Systems, Volume I is a collection of papers presented at the 1989 Bangalore Symposium on Oxygen Systems. This symposium covers various research studies on the essential roles, and the dangers of dioxygen reactions in biology. This volume is organized into five parts encompassing 32 chapters, and starts with an overview of the biological oxidation mechanisms involving oxygen and reduced oxygen derivatives. Parts I and II deal with the catalytic role of cytochrome P-450 and oxidase and oxygenase containing a flavin or pteridine enzymes in several biological oxidation reactions. These parts examine the biochemical aspects, reaction kinetics, and reaction mechanisms of such reactions. Parts III and IV describe first the structure function and properties of copper-containing oxidases and oxygenases. These parts also discuss the role of nonheme iron-containing and other oxygenases in the indole metabolism. Part V focuses on the role of peroxidase enzymes in cell protection and metabolism. This book will prove useful to biologists, enzyme scientists, and researchers.
Biological Oxidation Systems, Volume II discusses the various antioxidants and antioxidant enzymes that play significant roles in protecting cells from deleterious reactions between their structural/functional components and the free radicals. This book examines the myriad chemical reactions of a cell's metabolic activity that produce a variety of free radicals. Comprised of three parts encompassing 35 chapters, this volume starts with an overview of the metabolism of xenobiotics during arachidonic acid metabolism. This book then discusses the various causes of human cancers and diseases, which include exposure to environmental chemicals and other toxicants. This text considers the dietary habits and nutritional factors that play an important role in the causation and development of several human cancers, including cancer of the breast, colon, prostate, and other organs. Other chapters discuss the toxic effects of several xenobiotics that involve free-radical mechanisms. Biochemists, biophysicists, microbiologists, organic chemists, food chemists, and medical scientists will find this book extremely useful.
This book is ideal for use in a one-semester introductory course in physical chemistry for students of life sciences. The author's aim is to emphasize the understanding of physical concepts rather than focus on precise mathematical development or on actual experimental details. Subsequently, only basic skills of differential and integral calculus are required for understanding the equations. The end-of-chapter problems have both physiochemical and biological applications.
This book describes the methods of analysis and determination of oxidants and oxidative stress in biological systems. Reviews and protocols on select methods of analysis of ROS, RNS, oxygen, redox status, and oxidative stress in biological systems are described in detail. It is an essential resource for both novices and experts in the field of oxidant and oxidative stress biology.
In this second edition, Edwin Frankel has updated and extended his now well-known book Lipid oxidation which has come to be regarded as the standard work on the subject since the publication of the first edition seven years previously. His main objective is to develop the background necessary for a better understanding of what factors should be considered, and what methods and lipid systems should be employed, to achieve suitable evaluation and control of lipid oxidation in complex foods and biological systems. The oxidation of unsaturated fatty acids is one of the most fundamental reactions in lipid chemistry. When unsaturated lipids are exposed to air, the complex, volatile oxidation compounds that are formed cause rancidity. This decreases the quality of foods that contain natural lipid components as well as foods in which oils are used as ingredients. Furthermore, products of lipid oxidation have been implicated in many vital biological reactions, and evidence has accumulated to show that free radicals and reactive oxygen species participate in tissue injuries and in degenerative disease. Although there have been many significant advances in this challenging field, many important problems remain unsolved. This second edition of Lipid oxidation follows the example of the first edition in offering a summary of the many unsolved problems that need further research. The need to understand lipid oxidation is greater than ever with the increased interest in long-chain polyunsaturated fatty acids, the reformulation of oils to avoid hydrogenation and trans fatty acids, and the enormous attention given to natural phenolic antioxidants, including flavonoids and other phytochemicals.
Hailed by advance reviewers as "a kinder, gentler P. Chem. text," this book meets the needs of an introductory course on physical chemistry, and is an ideal choice for courses geared toward pre-medical and life sciences students. Physical Chemistry for the Chemical and Biological Sciences offers a wealth of applications to biological problems, numerous worked examples and around 1000 chapter-end problems.
Biology for AP® courses covers the scope and sequence requirements of a typical two-semester Advanced Placement® biology course. The text provides comprehensive coverage of foundational research and core biology concepts through an evolutionary lens. Biology for AP® Courses was designed to meet and exceed the requirements of the College Board’s AP® Biology framework while allowing significant flexibility for instructors. Each section of the book includes an introduction based on the AP® curriculum and includes rich features that engage students in scientific practice and AP® test preparation; it also highlights careers and research opportunities in biological sciences.
Oxidative Stress and Biomaterials provides readers with the latest information on biomaterials and the oxidative stress that can pose an especially troubling challenge to their biocompatibility, especially given the fact that, at the cellular level, the tissue environment is a harsh landscape of precipitating proteins, infiltrating leukocytes, released oxidants, and fluctuations of pH which, even with the slightest shift in stasis, can induce a perpetual state of chronic inflammation. No material is 100% non-inflammatory, non-toxic, non-teratogenic, non-carcinogenic, non-thrombogenic, and non-immunogenic in all biological settings and situations. In this embattled terrain, the most we can hope for from the biomaterials we design is a type of "meso-compatibility, a material which can remain functional and benign for as long as required without succumbing to this cellular onslaught and inducing a local inflammatory reaction. - Explores the challenges of designing and using biomaterials in order to minimize oxidative stress, reducing patterns of chronic inflammation and cell death - Brings together the two fields of biomaterials and the biology of oxidative stress - Provides approaches for the design of biomaterials with improved biocompatibility