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Cancer is clearly an age-related disease. Recent research in both aging and cancer has demonstrated the complex interaction between the two phenomena. This affects a wide spectrum of research and practice, anywhere from basic research to health care organization. Core examples of these close associations are addressed in this book. Starting with basic research, the first chapters cover cancer development, mTOR inhibition, senescent cells altering the tumor microenvironment, and immune senescence affecting cancer vaccine response. Taking into account the multidisciplinarity of geriatric oncology, several chapters focus on geriatric and oncologic aspects in patient assessment, treatment options, nursing and exercise programs. The book is rounded off by a discussion on the impact of the metabolic syndrome illustrating the interactions between comorbidity and cancer and a chapter on frailty.This book provides the reader with insights that will hopefully foster his or her reflection in their own research and practice to further the development of this most exciting field. Given the aging of the population worldwide and the high prevalence of cancer, it is essential reading not only for oncologists and geriatricians but for all health practitioners.
This volume highlights research issues specific to geriatric oncology in the field of carcinogenesis and cancer prevention and treatment, based on the biologic interactions of cancer and age. It conveys a sustainable way of thinking about cancer and aging.
Half the population of dogs and cats aged 10 and over will die of neoplasia. The bonds that clients have developed with their older pets are especially strong and drive the increasing demand for more proficient and highly compassionate medical treatment of companion animals diagnosed with cancer. This book offers more than just a competent clinical approach to the most common tumors in dogs and cats. This book also offers a focus on the special needs of geriatric pets and their owners. Amply illustrated with dozens of case studies representative of those regularly encountered in practice, Canine and Feline Geriatric Oncology will provide readers with the tools needed to diagnose and treat aging pets with cancer, and to help clients make the best decisions for themselves and for the animals with whom they share their lives. Canine and Feline Geriatric Oncology is a unique resource. It is a useful oncology reference for specialists, veterinarians in general practice, veterinary technicians, and clinic staff. The many "what ifs" that the practitioner inevitably faces in interactions with clients and their aging pets with cancer are presented and discussed. Special Features: * Focuses on the special needs of geriatric pets and their caregivers; * Offers direction in the diagnosis and treatment of aging pets with cancer; * Addresses many of the "what ifs" that arise in interactions with clients and aging pets with cancer; * Amply illustrated with full color throughout; * A valuable reference for practicing veterinarians, technicians, hospital staff, and professionals involved in supportive counseling for pet caregivers.
Published in 2004: This new edition of Comprehensive Geriatric Oncology still offers an exhaustive review of the biology of cancer and aging, of the epidemiologic trends in the country and in the world, and of the clinical trials that concern cancer prevention and cancer treatment in the elderly.
The fourth edition of the highly acclaimed Principles and Practice of Geriatric Medicine provides an account of the fundamental changes associated with ageing, which are essential to our understanding and management of the elderly sick population. The title has been extensively revised and updates to reflect the enormous changes in treatment options and medical conditions emerged since publication of the third edition. Written by worldwide experts of international repute, this is the most up-to-date and comprehensive single reference source currently available. Principles & Practice of Geriatric Medicine, Fourth Edition incorporates: More than 30 new chapters, including: Preventive geriatrics, Anorexia of Aging, Managements of Weight Loss, Dehydration, Vitamins and Minerals in the Elderly, Cancer and Aging, Mild Cognitive Impairment, Treatment of Behavioral Disorders, The Older Patient with Down's Syndrome, Drug Abuse in Older People, Breast Cancer, Women's health A truly global perspective, including new chapter on: Care of the elderly in Israel: old age in a young land, Geriatric Medicine in China, Geriatric medicine education in Europe, Geriatrics from the European Union Perspective, India, Day Hospitals, Perspectives from Latin America The title will be indispensable for all those involved in the treatment of older patients: Gerontologists to keep up-to-date with the latest developments in the field General practitioners and specialists in health policy and community care, who increasingly have to deal with a significant number of older people. Academic researchers in geriatric medicine, who are in need for an all encompassing reference work Medical registrars (UK) / residents (US) in order to pass their exams Teachers of Geriatric Medicine Hospital libraries with increasing budgets to spend on much needed resource in this growing field. Professionals within the pharmaceutical industry in order to monitor treatment options and new prescription developments.
This book is intended as a comprehensive resource for clinicians and researchers seeking in-depth information on geriatric oncology. The coverage encompasses epidemiology, the biology and (patho)physiology of aging and cancer, geriatric assessment and management, hematologic malignancies, solid tumors, issues in patient care, and research methods. Since cancer is a disease of aging and people are living longer, most cancer patients are now aged 70 and older. Yet the more we age, the more diverse we become in terms of our health, biologic fitness, and cancer behavior. Typically, however, general oncology clinical trials address only a selected healthier and younger population of patients. Geriatric oncology is the area of oncology that addresses these issues but while a wealth of knowledge has been accumulated, information is often difficult to retrieve or insufficiently detailed. The SpringerReference program, in which this book is published, offers an ideal format for overcoming these limitations since it combines thorough coverage with access to living editions constantly updated chapter by chapter via a dynamic peer-review process, ensuring that information remains current and pertinent.
This new edition of the comprehensive and renowned textbook Principles and Practice of Geriatric Medicine offers a fully revised and updated review of geriatric medicine. It covers the full spectrum of the subject, features 41 new chapters, and provides up-to-date, evidence-based, and practical information about the varied medical problems of ageing citizens. The three editors, from UK, USA and France, have ensured that updated chapters provide a global perspective of geriatric medicine, as well as reflect the changes in treatment options and medical conditions which have emerged since publication of the 4th edition in 2006. The book includes expanded sections on acute stroke, dementia, cardiovascular disease, and respiratory diseases, and features a new section on end-of-life care. In the tradition of previous editions, this all-encompassing text continues to be a must-have text for all clinicians who deal with older people, particularly geriatric medical specialists, gerontologists, researchers, and general practitioners. This title is also available as a mobile App from MedHand Mobile Libraries. Buy it now from Google Play or the MedHand Store. Praise for the 4th edition: "...an excellent reference for learners at all clinical and preclinical levels and a useful contribution to the geriatric medical literature." —Journal of the American Medical Association, November 2006 5th edition selected for 2012 Edition of Doody's Core TitlesTM
Accompanying CD-ROM contains video learning modules on gait and balance and dizziness, a dermatology quiz, and downloadable cognitive assessment tools, to hone clinical skills. File formats include QuickTime movies, PDFs, and HTML documents.
The study of the biology of tumours has grown to become markedly interdisciplinary, involving chemists, statisticians, epidemiologists, mathematicians, bioinformaticians, and computer scientists alongside biologists, geneticists, and clinicians. The Oxford Textbook of Cancer Biology brings together the most up-to-date developments from different branches of research into one coherent volume, providing a comprehensive and current account of this rapidly evolving field. Structured in eight sections, the book starts with a review of the development and biology of multi-cellular organisms, how they maintain a healthy homeostasis in an individual, and a description of the molecular basis of cancer development. The book then illustrates, as once cells become neoplastic, their signalling network is altered and pathological behaviour follows. It explores the changes that cancer cells can induce in nearby normal tissue, the new relationship established between them and the stroma, and the interaction between the immune system and tumour growth. The authors illustrate the contribution provided by high throughput techniques to map cancer at different levels, from genomic sequencing to cellular metabolic functions, and how information technology, with its vast amounts of data, is integrated with traditional cell biology to provide a global view of the disease. The effect of the different types of treatments on the biology of the neoplastic cells are explored to understand on the one side, why some treatments succeed, and on the other, how they can affect the biology of resistant and recurrent disease. The book concludes by summarizing what we know to date about cancer, and in what direction our understanding of cancer is moving. Edited by leading authorities in the field with an international team of contributors, this book is an essential resource for scholars and professionals working in the wide variety of sub-disciplines that make up today's cancer research and treatment community. It is written not only for consultation, but also for easy cover-to-cover reading.
This book presents comprehensive assessment and up-to-date discussion of the epidemiology, prevention, and treatment of cancer in the elderly, highlighting the growing demands of the disease, its biology, individual susceptibility, the impact of state-of-the-art and emerging therapies on reducing morbidity, and decision making processes. Describ