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This introductory textbook was first published in 1978. It was originally intended primarily for students who wanted to obtain a simplified picture of what viruses are like and how they can multiply and cause disease. Today, it still provides a general overall picture of virology, emphasising the underlying fundamental biochemical principles rather than detailing the complexities of different viruses or clinical problems. The mechanisms of replication and the variety of structures found in viruses are dealt with from a comparative standpoint. A working knowledge of proteins, nucleic acids and lipids is assumed.
The Molecular Biology of Viruses is a collection of manuscripts presented at the Third Annual International Symposium of the Molecular Biology of Viruses, held in the University of Alberta, Canada on June 27-30, 1966, sponsored by the Faculty of Medicine of the University of Alberta. This book is organized into eight parts encompassing 36 chapters that emphasize the biosynthetic steps involved in polymer duplication. The first two parts explore the specialized processes of the cycle of virulent and temperate bacteriophage multiplication. These parts also deal with the production, regulation of development, and selectivity of these bacteriophages. The subsequent two parts look into the heterozygosity, mutation, structure, function, and mode of infection of single-stranded DNA and RNA bacteriophages. The discussions then shift to the biological and physicochemical aspects, biosynthesis, translation, genetics, and replication of mammalian DNA and RNA viruses. The concluding parts describe the homology, interaction, functions, mechanism of transformation, metabolism, and carcinogenic activity of oncogenic viruses. This book is of great benefit to biochemists, biophysicists, geneticists, microbiologists, and virologists.
Viruses: Molecular Biology, Host Interactions, and Applications to Biotechnology provides an up-to-date introduction to human, animal and plant viruses within the context of recent advances in high-throughput sequencing that have demonstrated that viruses are vastly greater and more diverse than previously recognized. It covers discoveries such as the Mimivirus and its virophage which have stimulated new discussions on the definition of viruses, their place in the current view, and their inherent and derived ‘interactomics’ as defined by the molecules and the processes by which virus gene products interact with themselves and their host’s cellular gene products. Further, the book includes perspectives on basic aspects of virology, including the structure of viruses, the organization of their genomes, and basic strategies in replication and expression, emphasizing the diversity and versatility of viruses, how they cause disease and how their hosts react to such disease, and exploring developments in the field of host-microbe interactions in recent years. The book is likely to appeal, and be useful, to a wide audience that includes students, academics and researchers studying the molecular biology and applications of viruses Provides key insights into recent technological advances, including high-throughput sequencing Presents viruses not only as formidable foes, but also as entities that can be beneficial to their hosts and humankind that are helping to shape the tree of life Features exposition on the diversity and versatility of viruses, how they cause disease, and an exploration of virus-host interactions
This book contemplates the structure, dynamics and physics of virus particles: From the moment they come into existence by self-assembly from viral components produced in the infected cell, through their extracellular stage, until they recognise and infect a new host cell and cease to exist by losing their physical integrity to start a new infectious cycle. (Bio)physical techniques used to study the structure of virus particles and components, and some applications of structure-based studies of viruses are also contemplated. This book is aimed first at M.Sc. students, Ph.D. students and postdoctoral researchers with a university degree in biology, chemistry, physics or related scientific disciplines who share an interest or are actually working on viruses. We have aimed also at providing an updated account of many important concepts, techniques, studies and applications in structural and physical virology for established scientists working on viruses, irrespective of their physical, chemical or biological background and their field of expertise. We have not attempted to provide a collection of for-experts-only reviews focused mainly on the latest research in specific topics; we have not generally assumed that the reader knows all of the jargon and all but the most recent and advanced results in each topic dealt with in this book. In short, we have attempted to write a book basic enough to be useful to M.Sc and Ph.D. students, as well as advanced and current enough to be useful to senior scientists with an interest in Structural and/or Physical Virology.
A compendium of readily reproducible and novel methods to manipulate DNA viruses and characterize their varied biological properties. The authors emphasize techniques for viral detection and genetics, but also include methods for structure determination, gene expression, replication, pathogenesis, complex cellular models, recombinant genetics, and computational/systems approaches. Wide-ranging and highly practical, DNA Viruses: Methods and Protocols will stimulate new directions in virology research with its novel strategies for engineering viral vectors in gene therapy, and its advanced approaches for detecting viruses in human disease.
This book is the result of an international symposium held at the Institute of Virology and Immunobiology of the-University of WUrzburg, Germany, in October 1980. The intent of this symposium was to provide an opportunity to compare the data on coronavirus structure and replica tion as well as to discuss mechanisms of pathogenesis. For over a decade coronaviruses have been recognized as an important group of viruses which are responsible for a variety of diseases of clinical importance in animals and man. Recently new and interesting data on the molecular biology and pathogenesis of coronaviruses have become available and this led us to organize this meeting. The uniformity and diversity in this virus group was evaluated from a molecular point of view and the replication of coronaviruses appears to involve aspects which may be unique for this virus group. Additionally, in contrast to other positive strand RNA viruses it became clear that coronaviruses readily establish persistent infections in the host, a phenomenon which may lead to the different subacute or chronic disorders manifested during coronavirus infection. This volume presents a series of articles based upon the scientific presentation given at the symposium. In addition, there are two articles by B. W. J. Mahy and D. A. J. Tyrrell which summarize the current state of art concerning the biochemistry and biology of coronaviruses, respective ly. We believe this book will be of interest to all virologists and particularly to both established workers and newcomers to this field. V.
Virus Structure covers the full spectrum of modern structural virology. Its goal is to describe the means for defining moderate to high resolution structures and the basic principles that have emerged from these studies. Among the topics covered are Hybrid Vigor, Structural Folds of Viral Proteins, Virus Particle Dynamics, Viral Gemone Organization, Enveloped Viruses and Large Viruses. Covers viral assembly using heterologous expression systems and cell extracts Discusses molecular mechanisms in bacteriophage T7 procapsid assembly, maturation and DNA containment Includes information on structural studies on antibody/virus complexes
The recognition of viruses. The symptoms of viral infection, and virus assays. Methods for isolation and purification of viruses. Methods for preparation and characterization of the components of viruses. The proteins of viruses. The nucleic acids of viruses. Other viral components. Properties of virus particles and the nature of viral infectivity. Modification of viruses and their components, Mutagenesis, and genetics of viruses. The assembly and reconstitution of viruses. The replication of viruses. The biology of the tumor viruses. The biology of temperate phages, lysogeny, and transduction.