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This book addresses the molecular bases of some of the most important biochemical rhythms known at the cellular level. Clarifying the mechanism of these oscillatory phenomena is of key importance for understanding the origin as well as the physiological function of these rhythms, and the conditions in which simple periodic behaviour transforms into complex oscillations, including bursting and chaos. The approach rests on the analysis of theoretical models closely related to experimental observations. Among the main rhythms considered are glycolytic oscillations observed in yeast and muscle, oscillations of cyclic AMP in Dictyostelium amoebae, intracellular calcium oscillations observed in a variety of cell types, the mitotic oscillator that drives the cell division cycle in eukaryotes, and circadian oscillations of the period protein (PER) in Drosophila. For each of these phenomena, experimental facts are reviewed and mathematical models presented.
This book addresses the molecular bases of some of the most important biochemical rhythms known at the cellular level. The approach rests on the analysis of theoretical models closely related to experimental observations. Among the main rhythms considered are glycolytic oscillations observed in yeast and muscle, oscillations of cyclic AMP in Dictyostelium amoebae, intracellular calcium oscillation observed in a variety of cell types, the mitotic oscillator that drives the cell division cycle in eukaryotes, pulsatile hormone signaling, and circadian rhythms in Drosophila. This book will be of interest to life scientists such as biochemists, cell biologists, chronobiologists, medical scientists and pharmacologists. In addition, it will appeal to scientists studying nonlinear phenomena, including oscillations and chaos, in chemistry, physics, mathematics and theoretical biology.
An introduction to the mathematical, computational, and analytical techniques used for modeling biological rhythms, presenting tools from many disciplines and example applications. All areas of biology and medicine contain rhythms, and these behaviors are best understood through mathematical tools and techniques. This book offers a survey of mathematical, computational, and analytical techniques used for modeling biological rhythms, gathering these methods for the first time in one volume. Drawing on material from such disciplines as mathematical biology, nonlinear dynamics, physics, statistics, and engineering, it presents practical advice and techniques for studying biological rhythms, with a common language. The chapters proceed with increasing mathematical abstraction. Part I, on models, highlights the implicit assumptions and common pitfalls of modeling, and is accessible to readers with basic knowledge of differential equations and linear algebra. Part II, on behaviors, focuses on simpler models, describing common properties of biological rhythms that range from the firing properties of squid giant axon to human circadian rhythms. Part III, on mathematical techniques, guides readers who have specific models or goals in mind. Sections on “frontiers” present the latest research; “theory” sections present interesting mathematical results using more accessible approaches than can be found elsewhere. Each chapter offers exercises. Commented MATLAB code is provided to help readers get practical experience. The book, by an expert in the field, can be used as a textbook for undergraduate courses in mathematical biology or graduate courses in modeling biological rhythms and as a reference for researchers.
This textbook provides an introduction to dynamic modeling in molecular cell biology, taking a computational and intuitive approach. Detailed illustrations, examples, and exercises are included throughout the text. Appendices containing mathematical and computational techniques are provided as a reference tool.
​This book provides an overview of circadian rhythms and cellular networks in their relation to biological systems and dynamical medicine. Six concise chapters explore circadian cell rhythms and biomarkers in inflammation, cardiovascular disease, cancer, depression, and more in causing and treating these ailments. The final chapter discusses optimization of drug delivery and individualized treatment systems using chronotherapy and chronobiology-based biomarkers as a general system of medicine. Succinct yet comprehensive, Cellular Rhythms and Networks, part of SpringerBriefs in Cell Biology presents a novel framework for clinical applications in personalized and systems medicine. It is invaluable reading for researchers and clinicians in cell biology, mood disorders, and systems medicine.
Circadian rhythms, the biological oscillations based around our 24-hour clock, have a profound effect on human physiology and healthy cellular function. Circadian Rhythms: Health and Disease is a wide-ranging foundational text that provides students and researchers with valuable information on the molecular and genetic underpinnings of circadian rhythms and looks at the impacts of disruption in our biological clocks in health and disease. Circadian Rhythms opens with chapters that lay the fundamental groundwork on circadian rhythm biology. Section II looks at the impact of circadian rhythms on major organ systems. Section III then turns its focus to the central nervous system. The book then closes with a look at the role of biological rhythms in aging and neurodegeneration. Written in an accessible and informative style, Circadian Rhythms: Health and Disease,will be an invaluable resource and entry point into this fascinating interdisciplinary field that brings together aspects of neuroscience, cell and molecular biology, and physiology.
Biological and Biochemical Oscillators compiles papers on biochemical and biological oscillators from a theoretical and experimental standpoint. This book discusses the oscillatory behavior, excitability, and propagation phenomena on membranes and membrane-like interfaces; two-dimensional analysis of chemical oscillators; and chemiluminescence in oscillatory oxidation reactions catalyzed. The problems associated with the computer simulation of oscillating systems; mechanism of single-frequency glycolytic oscillations; excitation wave propagation during heart fibrillation; and biochemical cycle of excitation are also elaborated. This compilation likewise covers the physiological rhythms in Saccharomyces cerevisiae populations; integral and indissociable property of eukaryotic gene-action systems; and role of actidione in the temperature jump response of the circadian rhythm in Euglena gracilis. This publication is valuable to biochemists interested in biochemical and biological oscillations.
The Biological Clock describes the rhythmic processes in a great variety of plants and animals. This book is an outgrowth of the 1969 James Arthur Lecture Series on "Time and its Mysteries" held at New York University. This three-chapter work begins with the basic principles of biological rhythms and clocks, along with various diagrams to illustrate some aspects of circadian rhythms in animals. The second chapter discusses the hypothesis of environmental timing of the clock. This chapter explores numerous research studies on phenomenon of biological rhythms, the nature of the rhythmic mechanism, and hormonal regulation. The third chapter examines the cellular-biochemical clock hypothesis and its contribution in the progress of understanding the complexity of biological rhythm. This book is intended primarily for biologists, behaviorists, and researchers.
An intriguing class of biological periodicity consists of rhythms with about 24-hour periods occurring at every level of eukaryotic organization. Progress is being made in understanding these rhythms. The six chapters of this work include a brief introduction to circadian (24-hour) rhythms, a survey of circadian organization at the cellular level, and a description of the important microorganisms that have served as experimental models for biochemical analysis. Also considered are relations between cell division cycles and circadian oscillators, as well as some general and theoretical aspects. Where appropriate, parallels are drawn to neuronal oscillators. This volume will introduce and critically appraise modern chronobiology; its extensive illustrations and comprehensive up-to-date bibliography will make it an authoritative reference.
Recent years have seen spectacular advances in the field of circadian biology. These have attracted the interest of researchers in many fields, including endocrinology, neurosciences, cancer, and behavior. By integrating a circadian view within the fields of endocrinology and metabolism, researchers will be able to reveal many, yet-unsuspected aspects of how organisms cope with changes in the environment and subsequent control of homeostasis. This field is opening new avenues in our understanding of metabolism and endocrinology. A panel of the most distinguished investigators in the field gathered together to discuss the present state and the future of the field. The editors trust that this volume will be of use to those colleagues who will be picking up the challenge to unravel how the circadian clock can be targeted for the future development of specific pharmacological strategies toward a number of pathologies.