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Part of Water Quality Set - Buy all four books and save over 30% on buying separately! Bioanalytical Tools in Water Quality Assessment reviews the application of bioanalytical tools to the assessment of water quality including surveillance monitoring. The types of water included range from wastewater to drinking water, including recycled water, as well as treatment processes and advanced water treatment. Bioanalytical Tools in Water Quality Assessment not only demonstrates applications but also fills in the background knowledge in toxicology/ecotoxicology needed to appreciate these applications. Each chapter summarises fundamental material in a targeted way so that information can be applied to better understand the use of bioanalytical tools in water quality assessment. Bioanalytical tools in Water Quality Assessment can be used by lecturers teaching academic and professional courses and also by risk assessors, regulators, experts, consultants, researchers and managers working in the water sector. It can also be a reference manual for environmental engineers, analytical chemists, and toxicologists. Authors: Beate Escher, National Research Centre for Environmental Toxicology (EnTox), The University of Queensland, Australia, Frederic Leusch, Smart Water Research Facility (G51), Griffith University Gold Coast Campus, Australia. With contributions by Heather Chapman and Anita Poulsen
Endocrine disrupting chemicals (EDCs) are contaminants of emerging environmental and health concern that have been detected in freshwater, wastewater and drinking water. They interfere with the endocrine system in humans and wildlife, and produce adverse effects such as developmental, reproductive, neurological and immune effects.
This book provides comprehensive coverage of the theoretical developments and technological breakthroughs that have deepened our understanding of environmental pollution and human health, while also promoting a comprehensive strategy to address these problems. The respective chapters highlight groundbreaking concepts fueling the development of environmental chemistry and toxicology; revolutionary analytical and computational approaches providing novel insights into environmental health; and nature-inspired, innovative engineering solutions for tackling complex hazardous exposures. The book also features a forward-looking perspective on emerging environmental issues that call for new research and regulatory paradigms, laying the groundwork for future advances in the broad field of environmental chemistry and toxicology. Written by respected authorities in the field, A New Paradigm for Environmental Chemistry and Toxicology - From Concepts to Insights will offer an invaluable reference guide for concerned researchers and professional practitioners for years to come.
Existe una creciente preocupación medioambiental debida la presencia de microcontaminantes orgánicos en los sistemas acuáticos. La escasa eficiencia en la degradación de contaminantes orgánicos persistentes en las plantas de tratamiento de aguas residuales convencionales basadas en procesos biológicos constituye uno de los principales fuentes de su emisión en el medio ambiente. Esto significa la liberación continua en el ciclo del agua de sustancias que aunque se encuentran en muy bajas concentraciones, han sido reconocidas como potencialmente peligrosas para el medio ambiente y la salud humana. Por tanto, para la eliminación de estas sustancias se está investigando la inclusión de un tratamiento terciario en las estaciones depuradoras de aguas residuales. En este respecto, los procesos de oxidación avanzada (POA) han sido ampliamente investigados debido a la generación de radicales hidroxilos altamente reactivos, capaces de oxidar compuestos orgánicos. Entre ellos, el proceso foto-Fenton ha demostrado ser eficaz en la eliminación de microcontaminantes. Sin embargo, todavía se necesita investigar en la operación de este proceso para su aplicación en plantas de tratamiento de aguas residuales a escala real. Este trabajo ha sido diseñado para evaluar diferentes estrategias de operación del proceso foto-Fenton como tratamiento terciario para eliminar microcontaminantes en efluentes secundarios de la industria agroalimentaria (“Cítricos del Andarax S.A.”, Almería, España) y de plantas de tratamiento de aguas residuales municipales. La evaluación se ha realizado en función de las características de las distintas matrices de agua así como por la viabilidad de escalar el proceso a niveles reales utilizando un reactor de bajo costo tipo “raceway”. Los reactores “raceway” son fotorreactores extensivos formados por canales donde el líquido es movido por un agitador de palas y que permiten tratar grandes volúmenes de agua. En resumen, el trabajo presentado en esta tesis muestra que controlar el pH durante la depuración biológica de aguas residuales de industria agro-alimentaria facilita la eliminación de microcontaminantes mediante el proceso de foto-Fenton y que reduce los costes de reactivos. Además, el exceso de fango generado durante el tratamiento biológico puede ser reducido por ultrasonicación del fango purgado y degrada la mayoría de los plaguicidas absorbidos en el fango. Por otro lado, los reactores tipo “raceway” permiten altas capacidades de tratamiento para la eliminación de microcontaminantes mediante procesos de Fenton solares como la dosificación secuencial de hierro y el uso del complejo Fe3+/EDDS, habiendo demostrado ser tratamientos eficientes en la eliminación de microcontaminates y toxicidad en efluentes secundarios de depuradoras de aguas residuales.
Sample Handling and Trace Analysis of Pollutants: Innovations to Determine Organic Contaminants, Second Edition reviews the latest technologies and challenges in trace analysis of environmental pollutants, from selecting the right approach to tips for performing analytic procedures and measuring and reporting results. Written by internationally renowned experts in environmental analysis from 5 continents and edited by leaders in the field, this completely updated and revised volume presents the latest techniques developed over the past 10 years, such as high-resolution mass spectrometry, biosensors and imaging techniques. Important tools for problem-solving in the determination of environmental pollutants are also discussed.Chapters cover emerging pollutants in the environment, such as nanomaterials, microplastics, metabolites and/or transformation products and antimicrobial resistances. Specific sections describe field sampling techniques and sample preparation in environmental matrices: air, water, soil, sediment and biota, focus on passive samplers, cover the determination of these environmental contaminants based on analytical techniques, such as the use of gas chromatography and liquid chromatography coupled to mass spectrometry, immunoassays, and biosensors as well as advanced analytical methods such as imaging techniques. - Discusses techniques ranging from chromatography coupled to mass spectrometry, to emerging areas such as nanotechnology, immunoassays and biosensors - Covers the characteristics, advantages, limitations and potential of each technique and the current strategies in each method's development and validation - Outlines practical solutions to challenging problems in the analysis of pollutants in environmental matrices, including how to combine techniques for improved efficacy
Many aspects of drug safety have become an outstanding and even persistent issue and may occur during the process of both drug discovery and development. Until 15 years ago, drug discovery and evaluation was primarily a sequential process starting with the selection of the most pharmacologically active compound from a series of newly synthesized small molecule chemical series by means of distinctive pharmacological assays. Safety aspects were addressed by evaluation of the selected compound at high doses in a series of specific studies directed at indications other than the intended indication of the new compound. These tests are then followed by pharmacokinetic studies, which are primarily conducted to confirm whether the selected compound possesses a suitable half-life for sufficient exposure and efficacy and, whether it has the desired properties specificity to the intended route of administration. Safety aspects relied predominantly on the conduct of single and repeat toxicologydose studies, which inform changes in organ structure rather than organ function. Both toxicological and pharmacokinetic studies are adapted to the progress of studies in clinical pharmacology and clinical trials. The new edition of this well and broadly accepted reference work contains several innovative and distinguished chapters. This "sequential" strategy has been abandoned with this new version of the book for several reasons: - Of the possible multitude of negative effects that novel drugs may impart on organ function, e.g. ventricular tachy-arrhythmia, many are detected too late in non-clinical studies to inform clinicians. On the other hand, negative findings in chronic toxicity studies in animals may turn out to be irrelevant for human beings. - New scientific approaches, e.g. high-throughput screening, human pluripotent stem cells, transgenic animals, knock-out animals, in silico models, pharmaco-genomics and pharmaco-proteomics, as well as Artificial Intelligence (AI) methods offered new possibilities. - There are several examples, that show that the "druggability" of compounds was considerably underestimated when the probability of success of a new project was assessed. The success rate in the pharmaceutical industry and the introduction of new chemical entities to the market per year dropped dramatically, whereas the development time for a new compound increased, sometimes exceeding the patent protection. Research and development scientists, involving the following changes, therefore adopted a change of strategy: - Parallel instead of sequential involvement of the various disciplines (multidimensional compound optimization). - The term "Safety Pharmacology" was coined. The International Conference on Harmonization (ICH) founded a Safety Pharmacology Working Group and the Safety Pharmacology Society (SPS) was launched. The discipline provided for evaluation, development and validation of a multitude of safety tests outlined in the 'Core Battery of Studies'. - Characterizing the exposure profile of a drug by conducting pharmacokinetic studies that evaluates the absorption, distribution, metabolism and excretion should to be investigated at an early stage of development as results contribute to the selection of a compound for further development. Advancements in Toxicology were achieved by the introduction of new methods, e.g., in silico methods, genetic toxicology, computational toxicology and AI. The book is a landmark in the continuously changing world of drug research and developments. As such, it is essential reading for many groups: not only for all students of pharmacology and toxicology but also for industry scientists and physicians, especially those involved in clinical trials of drugs, and for pharmacists who must know the safety requirements of drugs. The book is essential for scientists and managers in the pharmaceutical industry who are involved in drug discovery, drug development and decision making in the development process. In particular, the book will be of use to government institutions and committees working on official guidelines for drug evaluation worldwide.
Water Quality Monitoring and Management: Basis, Technology and Case Studies presents recent innovations in operations management for water quality monitoring. It highlights the cost of using and choosing smart sensors with advanced engineering approaches that have been applied in water quality monitoring management, including area coverage planning and sequential scheduling. In parallel, the book covers newly introduced technologies like bulk data handling techniques, IoT of agriculture, and compliance with environmental considerations. Presented from a system engineering perspective, the book includes aspects on advanced optimization, system and platform, Wireless Sensor Network, selection of river water quality, groundwater quality detection, and more. It will be an ideal resource for students, researchers and those working daily in agriculture who must maintain acceptable water quality. - Discusses field operations research and application in water science - Includes detection methods and case analysis for water quality management - Encompasses rivers, lakes, seas and groundwater - Covers water for agriculture, aquaculture, drinking and industrial uses
This book introduces the 3R concept applied to wastewater treatment and resource recovery under a double perspective. Firstly, it deals with innovative technologies leading to: Reducing energy requirements, space and impacts; Reusing water and sludge of sufficient quality; and Recovering resources such as energy, nutrients, metals and chemicals, including biopolymers. Besides targeting effective C,N&P removal, other issues such as organic micropollutants, gases and odours emissions are considered. Most of the technologies analysed have been tested at pilot- or at full-scale. Tools and methods for their Economic, Environmental, Legal and Social impact assessment are described. The 3R concept is also applied to Innovative Processes design, considering different levels of innovation: Retrofitting, where novel units are included in more conventional processes; Re-Thinking, which implies a substantial flowsheet modification; and Re-Imagining, with completely new conceptions. Tools are presented for Modelling, Optimising and Selecting the most suitable plant layout for each particular scenario from a holistic technical, economic and environmental point of view.
The book provides a comprehensive and up-to-date overview of the most modern concepts and tools needed to perform prospective and retrospective ecological risk assessments of environmental stressors, and will therefore be useful for students, teachers, scientists, regulators, and professionals in environmental consulting. Experimental methods and predictive theoretical approaches are described to evaluate and estimate the exposure of ecosystems to environmental stressors and to investigate their effects on different hierarchical levels of ecological organization (individuals, populations, communities, ecosystems). Specific sections are dedicated to the persistence and bioavailability of contaminants, bioaccumulation models, and the mechanisms of global pollution. Risk assessment procedures for the most relevant classes of traditional and emerging stressors, including physical agents, are described in detail in specific sections. Finally, regulatory instruments and public perception of risk are discussed.