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Public health has, for many years, been concerned with efforts to increase the efficiency of health care delivery, to measure changes in health care resource utilization and associated costs, and to link these changes to different types of interventions. These efforts, as well as collaboration between biopharmaceutical organizations, producers of medical devices, and managed care and public health organizations, have been enhanced by the opportunities created within the fast growing field of outcomes research. This volume presents studies contributing to the enhancement of the outcomes research paradigm by incorporating economic and social interactions within the health care delivery, clinical decision-making and outcomes systems. A multidisciplinary team of scientists in the fields of outcomes research, pharmacoeconomics, public health, health services research, and health economics address such complex problems as: benefits and cost of advancements in genetic technologies; methodologies for constructing health care utilization and cost estimates; and the effect of insurance type on resource utilization and health outcomes. Other studies consider both the types of drugs purchased and the prices paid, pharmaceutical spending and health outcomes, incremental advantages of newer treatments, willingness to pay measurements, disease-specific impacts on human capital and quality of life, and modelling clinical trial results. One of the most important findings in this book is the description of the role of low energy in the symptomatology of depression and its strong relationship with absenteeism, work productivity and social functioning. Another paper documents the disease-specific mortality, case-fatality and annual health care utilization in diabetics and establishes the association of respiratory conditions with elevated mortality among diabetics. The work contains other papers which provide significant results in cardiovascular, infectious, central nervous system disease areas as well as in quality of life and health outcomes measurements.
Neuromodulation is among the fastest-growing areas of medicine, involving many diverse specialties and affecting hundreds of thousands of patients with numerous disorders worldwide. It can briefly be described as the science of how electrical, chemical, and mechanical interventions can modulate the nervous system function. A prominent example of neuromodulation is deep brain stimulation (DBS), an intervention that reflects a fundamental shift in the understanding of neurological and psychiatric diseases: namely as resulting from a dysfunctional activity pattern in a defined neuronal network that can be normalized by targeted stimulation. The application of DBS has grown remarkably and more than 130,000 patients worldwide have obtained a DBS intervention in the past 30 years—most of them for treating movement disorders. This Frontiers Research Topics provides an overview on the current discussion beyond basic research in DBS and other brain stimulation technologies. Researchers from various disciplines, who are working on broader clinical, ethical and social issues related to DBS and related neuromodulation technologies, have contributed to this research topic.
This book fills a significant research gap in how to integrate quality of life data into relevant clinical care plans, and to broaden its applicability to pharmacoeconomic studies of antipsychotic medications and health policy decision-making. It also presents an argument for reformulating the concept of health-related quality of life in schizophrenia as a bio-psycho-social construct, which provides an opportunity to better explore the many factors underpinning the concept itself. Internationally renowned experts from different scientific backgrounds and scopes of expertise each make arguments for the need to invigorate quality of life as a concept in schizophrenia, by broadening its usefulness for clinical and research efforts. The book represents an important addition to the extensive contributions of its editors, Dr. A. George Awad and Dr. Lakshmi N.P. Voruganti, to the field of quality of life.
Reveals proven solutions for bettering the lives of people with serious mental illness, their families, and their communities. Leading scientist and gifted storyteller Rachel A. Pruchno, PhD, was shocked to encounter misinformation, ignorance, and intolerance when she sought to help her daughter, newly diagnosed with bipolar disorder. Turning to the scientific literature, Dr. Pruchno eventually found solutions, but she realized many others would need help to understand the highly technical writing and conflicting findings. In Beyond Madness—part memoir, part history, and part empathetic guide—Dr. Pruchno draws on her decades as a mental health professional, her own family's experiences with mental illness, and extensive interviews with people with serious mental illness to discuss how individuals live with these illnesses, including bipolar disorder, schizophrenia, and major depression. The book • presents real-world vignettes that vividly describe what it is like to experience some of the most troubling symptoms of a severe mental illness • offers practical advice for how individuals, family members, and communities can help people with a serious mental illness • explains how people with mental illness can find competent health care providers, identify treatment regimens, overcome obstacles to treatment, cope with stigma, and make decisions • provides insight into programs, such as Crisis Intervention Training, that can help people undergoing mental health crisis avoid jail and get the treatment they need • takes aim at the popular concept of "rock bottom" and reveals why this is such a harmful and simplistic approach • advocates for evidence-based care • documents examples of communities that have embraced successful strategies for promoting recovery • shows that people with serious mental illnesses can live productive lives Meticulously researched and engagingly written, Beyond Madness is a call to action and a promise of hope for everyone who cares about and interacts with the millions of people who have serious mental illness. Family members, friends, teachers, police, primary care doctors, and clergy—people who recognize that something is wrong but don't know how to help—will find the book's practical advice invaluable.
This eBook is a collection of articles from a Frontiers Research Topic. Frontiers Research Topics are very popular trademarks of the Frontiers Journals Series: they are collections of at least ten articles, all centered on a particular subject. With their unique mix of varied contributions from Original Research to Review Articles, Frontiers Research Topics unify the most influential researchers, the latest key findings and historical advances in a hot research area! Find out more on how to host your own Frontiers Research Topic or contribute to one as an author by contacting the Frontiers Editorial Office: frontiersin.org/about/contact.
Personalized Psychiatry presents the first book to explore this novel field of biological psychiatry that covers both basic science research and its translational applications. The book conceptualizes personalized psychiatry and provides state-of-the-art knowledge on biological and neuroscience methodologies, all while integrating clinical phenomenology relevant to personalized psychiatry and discussing important principles and potential models. It is essential reading for advanced students and neuroscience and psychiatry researchers who are investigating the prevention and treatment of mental disorders. - Combines neurobiology with basic science methodologies in genomics, epigenomics and transcriptomics - Demonstrates how the statistical modeling of interacting biological and clinical information could transform the future of psychiatry - Addresses fundamental questions and requirements for personalized psychiatry from a basic research and translational perspective
Ketamine for Treatment-Resistant Depression: Neurobiology and Applications provides a simple, evidence-based overview for neuropsychiatrists and translational researchers on this medication, its mechanisms of actions, eligibility of patients for treatment, and the preparation and implementation of ketamine clinics. - Provides efficacy research on ketamine as a treatment for depression - Identifies best practices for clinical use, both long-term and acute - Discusses the molecular mechanisms and neurobiology of action
It is an interesting topic to discuss addiction and love in the context of reward. In this e-book, we begin with an animal study of comparison between drug and natural reward. Then, some papers aim to understand the reward system underlying behavioral addiction focusing on technology, for example Internet addiction and mobile phone dependence. The third part of this e-book addresses the topic of love. Considered as a whole, this e-book demonstrates that drug and behavioral addictions are frequently related with negative consequences, while romantic love is related with a positive consequence. That's why romantic love may be considered as a natural addiction. We think that the notion of romantic love as a positive addiction may offer a new view for future research in the field.