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There is a logical flaw in the statistical methods used across experimental science. This fault is not a minor academic quibble: it underlies a reproducibility crisis now threatening entire disciplines. In an increasingly statistics-reliant society, this same deeply rooted error shapes decisions in medicine, law, and public policy with profound consequences. The foundation of the problem is a misunderstanding of probability and its role in making inferences from observations. Aubrey Clayton traces the history of how statistics went astray, beginning with the groundbreaking work of the seventeenth-century mathematician Jacob Bernoulli and winding through gambling, astronomy, and genetics. Clayton recounts the feuds among rival schools of statistics, exploring the surprisingly human problems that gave rise to the discipline and the all-too-human shortcomings that derailed it. He highlights how influential nineteenth- and twentieth-century figures developed a statistical methodology they claimed was purely objective in order to silence critics of their political agendas, including eugenics. Clayton provides a clear account of the mathematics and logic of probability, conveying complex concepts accessibly for readers interested in the statistical methods that frame our understanding of the world. He contends that we need to take a Bayesian approach—that is, to incorporate prior knowledge when reasoning with incomplete information—in order to resolve the crisis. Ranging across math, philosophy, and culture, Bernoulli’s Fallacy explains why something has gone wrong with how we use data—and how to fix it.
Probability theory
Another title in the reissued Oxford Classic Texts in the Physical Sciences series, Jeffrey's Theory of Probability, first published in 1939, was the first to develop a fundamental theory of scientific inference based on the ideas of Bayesian statistics. His ideas were way ahead of their time and it is only in the past ten years that the subject of Bayes' factors has been significantly developed and extended. Until recently the two schools of statistics (Bayesian and Frequentist) were distinctly different and set apart. Recent work (aided by increased computer power and availability) has changed all that and today's graduate students and researchers all require an understanding of Bayesian ideas. This book is their starting point.
A comprehensive survey of a rapidly expanding field of combinatorial optimization, mathematically oriented but offering biological explanations when required. From one cell to another, from one individual to another, and from one species to another, the content of DNA molecules is often similar. The organization of these molecules, however, differs dramatically, and the mutations that affect this organization are known as genome rearrangements. Combinatorial methods are used to reconstruct putative rearrangement scenarios in order to explain the evolutionary history of a set of species, often formalizing the evolutionary events that can explain the multiple combinations of observed genomes as combinatorial optimization problems. This book offers the first comprehensive survey of this rapidly expanding application of combinatorial optimization. It can be used as a reference for experienced researchers or as an introductory text for a broader audience. Genome rearrangement problems have proved so interesting from a combinatorial point of view that the field now belongs as much to mathematics as to biology. This book takes a mathematically oriented approach, but provides biological background when necessary. It presents a series of models, beginning with the simplest (which is progressively extended by dropping restrictions), each constructing a genome rearrangement problem. The book also discusses an important generalization of the basic problem known as the median problem, surveys attempts to reconstruct the relationships between genomes with phylogenetic trees, and offers a collection of summaries and appendixes with useful additional information.
Is there a secret formula for getting rich? For going viral? For deciding how long to stick with your current job, Netflix series, or even relationship? This book is all about the equations that make our world go round. Ten of them, in fact. They are integral to everything from investment banking to betting companies and social media giants. And they can help you to increase your chance of success, guard against financial loss, live more healthfully, and see through scaremongering. They are known by only the privileged few - until now. With wit and clarity, mathematician David Sumpter shows that it isn't the technical details that make these formulas so successful. It is the way they allow mathematicians to view problems from a different angle - a way of seeing the world that anyone can learn. Empowering and illuminating, The Ten Equations shows how math really can change your life.
Uncertainty is everywhere. It lurks in every consideration of the future - the weather, the economy, the sex of an unborn child - even quantities we think that we know such as populations or the transit of the planets contain the possibility of error. It's no wonder that, throughout that history, we have attempted to produce rigidly defined areas of uncertainty - we prefer the surprise party to the surprise asteroid. We began our quest to make certain an uncertain world by reading omens in livers, tea leaves, and the stars. However, over the centuries, driven by curiosity, competition, and a desire be better gamblers, pioneering mathematicians and scientists began to reduce wild uncertainties to tame distributions of probability and statistical inferences. But, even as unknown unknowns became known unknowns, our pessimism made us believe that some problems were unsolvable and our intuition misled us. Worse, as we realized how omnipresent and varied uncertainty is, we encountered chaos, quantum mechanics, and the limitations of our predictive power. Bestselling author Professor Ian Stewart explores the history and mathematics of uncertainty. Touching on gambling, probability, statistics, financial and weather forecasts, censuses, medical studies, chaos, quantum physics, and climate, he makes one thing clear: a reasonable probability is the only certainty.
Valerie Gray Hardcastle argues that both professional and lay definitions of pain are wrongheaded -- with consequences for how pain and pain patients are treated, how psychological disorders are understood, and how clinicians define the mind/body relationship. Pain, although very common, is little understood. Worse still, according to Valerie Gray Hardcastle, both professional and lay definitions of pain are wrongheaded -- with consequences for how pain and pain patients are treated, how psychological disorders are understood, and how clinicians define the mind/body relationship. Hardcastle offers a biologically based complex theory of pain processing, inhibition, and sensation and then uses this theory to make several arguments: (1) psychogenic pains do not exist; (2) a general lack of knowledge about fundamental brain function prevents us from distinguishing between mental and physical causes, although the distinction remains useful; (3) most pain talk should be eliminated from both the folk and academic communities; and (4) such a biological approach is useful generally for explaining disorders in pain processing. She shows how her analysis of pain can serve as a model for the analysis of other psychological disorders and suggests that her project be taken as a model for the philosophical analysis of disorders in psychology, psychiatry, and neuroscience.
Information theory and inference, taught together in this exciting textbook, lie at the heart of many important areas of modern technology - communication, signal processing, data mining, machine learning, pattern recognition, computational neuroscience, bioinformatics and cryptography. The book introduces theory in tandem with applications. Information theory is taught alongside practical communication systems such as arithmetic coding for data compression and sparse-graph codes for error-correction. Inference techniques, including message-passing algorithms, Monte Carlo methods and variational approximations, are developed alongside applications to clustering, convolutional codes, independent component analysis, and neural networks. Uniquely, the book covers state-of-the-art error-correcting codes, including low-density-parity-check codes, turbo codes, and digital fountain codes - the twenty-first-century standards for satellite communications, disk drives, and data broadcast. Richly illustrated, filled with worked examples and over 400 exercises, some with detailed solutions, the book is ideal for self-learning, and for undergraduate or graduate courses. It also provides an unparalleled entry point for professionals in areas as diverse as computational biology, financial engineering and machine learning.
Students in the sciences, economics, psychology, social sciences, and medicine take introductory statistics. Statistics is increasingly offered at the high school level as well. However, statistics can be notoriously difficult to teach as it is seen by many students as difficult and boring, if not irrelevant to their subject of choice. To help dispel these misconceptions, Gelman and Nolan have put together this fascinating and thought-provoking book. Based on years of teaching experience the book provides a wealth of demonstrations, examples and projects that involve active student participation. Part I of the book presents a large selection of activities for introductory statistics courses and combines chapters such as, 'First week of class', with exercises to break the ice and get students talking; then 'Descriptive statistics' , collecting and displaying data; then follows the traditional topics - linear regression, data collection, probability and inference. Part II gives tips on what does and what doesn't work in class: how to set up effective demonstrations and examples, how to encourage students to participate in class and work effectively in group projects. A sample course plan is provided. Part III presents material for more advanced courses on topics such as decision theory, Bayesian statistics and sampling.