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Behçet’s Syndrome has seen great strides over the last two decades in the availability of new treatments and the understanding of underlying pathogenesis. Only 30 years ago the majority of particularly young men with Behçet’s lost total eye sight, now only a minority do. This book covers the most recent developments in the basic and clinical aspects of Behçet’s Syndrome. International authorities have collaborated to offer their diverse expert knowledge on the multiple affected organs and systems, including the skin, the eye, the brain, the lungs and not the least the gastrointestinal and the locomotor systems. A special chapter is devoted to juvenile disease. The definitive resource on Behçet’s Syndrome, this book is well suited for rheumatologists, dermatologists, ophthalmologists, neurologists, and health professionals caring for Behçet’s patients.
It is with great pleasure that I write this Foreword to the Proceedings of the International Conference on Behçet’s Disease which was held in Berlin in June 2002. This was the first International Conference held under the auspices of the International Society for Behçet’s Disease which was founded in 2000 in Seoul. First, I congratulate our colleagues in Berlin, led by Professor Christos Zouboulis of the Department of Dermatology at the Free University of Berlin, for having organised a most successful conference and for having compiled these proceedings so rapidly. It will be realised immediately on scanning the contents of this book that the conference was truly international with 210 participants from 26 countries, as Professor Zouboulis has noted in his preface. These included basic scientists, epidemiologists, pathologists, clinicians and, importantly, representatives from patient organisations. The latter held their own conference alongside the scientific-medical conference to mutual benefit. The combined session of patients and doctors (abstracts on pp 601 – 626) gave the opportunity for an exchange of information and fruitful discussion. The wide ranging scope of the communications is evident from the index and it was most encouraging to see their origin – from all parts of the world, from senior and junior colleagues and, from many different disciplines. Many communications may be regarded as preliminary reports of research in progress and we look forward to seeing the definitive publications in appropriate journals in due course.
Bridging the wide information gap for the clinician and researcher alike, this text contains numerous clinical photographs, statistical data, and concise descriptions of the initial mucocutaneous symptoms, to help the clinician to understand and identify the disease. Other manifestations of BD in such systems as the cardiac, vascular, pulmonary, gastrointestinal, to name a few, are also described. In addition, the book surveys the drugs and other therapeutic modalities known to have beneficial effects. Lastly, the books synopsis of the pathogenic and immunologic features of the disease will be useful to scientists interested in the research aspects of BD.
Clinical Rheumatology is a book written by a clinician for clinicians. It covers all the essential clinical aspects of Rheumatology in an engaging, clear, and concise manner, thereby fulfilling an unmet need. The focus of this book is to cover clinically pertinent and practically relevant issues while pruning unnecessary detail. Patient photographs, tables, and boxes enhance readability. The bedside clinical and investigative approach is discussed in a lucid fashion illustrated by clinical photographs, flowcharts, and algorithms. The evidence-based treatment is spelt out in an easy to comprehend fashion. Key messages have been listed at the beginning of each chapter. The book is intended for undergraduate and postgraduate medical students, residents, fellows, and clinicians who want to gain practical knowledge and clinical insight into rheumatic diseases. The book is likely to appeal to internists, rheumatologists, physiatrists, physiotherapists, occupational therapists, as well as orthopaedic surgeons. They will find their day to day questions answered in a knowledge format that can be applied straight away. Senior clinicians will find it a ready reckoner and a handy manual to refresh and update their knowledge. Basic scientists will find it useful to gain clinical insight into the rheumatic diseases they research without being intimidated by the size of the text. Teachers will find it full of helpful teaching messages. Clinical Rheumatology is a must-have book for all those who deal with rheumatic musculoskeletal diseases.
This contributed volume provides a complete overview of Neuro-Behçet’s disease (NBD), one of the most serious manifestations of Behçet’s disease. It serves as a comprehensive and critical review of the current scientific literature regarding NBD, covering the epidemiology, pathology, prognosis, and treatment of the disease. This book is an essential resource for both researchers and physicians working on neurology, rheumatology, and internal medicine fields.
This one-of-a-kind reference provides a comprehensive and practical guide to help you interpret endoscopic biopsies and resection specimens of all organs related to the digestive system. Plus, thanks to Expert Consult, you'll be able to access the entire contents of this title online and download all images, from anywhere there's an internet connection. The more than 2250 high quality illustrations, 30% more than in the first edition, help you recognize and diagnose any tissue sample under the microscope. Five new chapters, additional expert authors, expanded tables, and coverage of the current clinical approach to management and treatment options, particularly screening and surveillance recommendations for preneoplastic disorders, round out this unique reference. Acts as a one-stop resource for the entire gastrointestinal system, liver, biliary tract, and pancreas. Incorporates over 2250 high quality color illustrations so you can recognize and diagnose any tissue sample under the microscope. Provides all the necessary tools to make a comprehensive diagnostic workup including data from ancillary techniques and molecular findings whenever appropriate. Simplifies complex topics and streamlines decision-making using extensive tables, graphs, and flowcharts. Helps you avoid diagnostic errors thanks to practical advice on pitfalls in differential diagnosis. Uses a new "road map" at the beginning of each chapter, as well as a new, more clinical focus to help you navigate through the book more quickly. Reflects the latest classification and staging systems available so you can provide the clinician with the most accurate and up-to-date diagnostic and prognostic indicators, including key molecular aspects of tumor pathology. Includes access to the entire contents online, from anywhere there's an internet connection. Adds five new chapters including "Screening and Surveillance of the GI Tract", "Congenital and Developmental Disorders of the GI Tract", "Pediatric Enteropathies of the GI Tract", "Vascular Disorders of the GI Tract", and "Fatty Liver Disease". Expands appropriate chapters with new coverage of the normal histology of the GI tract, liver, biliary tract and pancreas. Uses expanded tables to outline specific differential diagnostic points helpful for surgical pathologists. Discusses the key molecular aspects of tumor progression and risk assessment in all chapters that cover neoplastic disorders. Helps you evaluate diagnostically challenging cases using diagnostic algorithms. Increases the number of high quality photographs by at least 30% to include even more normal and abnormal tissue samples. Updates all chapters to include the latest references, concepts, data, and controversies. Incorporates expanded coverage of the pancreas and liver, eliminating the need for a separate text. Your purchase entitles you to access the web site until the next edition is published, or until the current edition is no longer offered for sale by Elsevier, whichever occurs first. If the next edition is published less than one year after your purchase, you will be entitled to online access for one year from your date of purchase. Elsevier reserves the right to offer a suitable replacement product (such as a downloadable or CD-ROM-based electronic version) should access to the web site be discontinued.
Medical Epigenetics provides a comprehensive analysis of the importance of epigenetics to health management. The purpose of this book is to fill a current need for a comprehensive volume on the medical aspects of epigenetics with a focus on human systems, epigenetic diseases that affect these systems and modes of treating epigenetic-based disorders and diseases. The intent of this book is to provide a stand-alone comprehensive volume that will cover all human systems relevant to epigenetic maladies and all major aspects of medical epigenetics. The overall goal is to provide the leading book on medical epigenetics that will be useful not only to physicians, nurses, medical students and many others directly involved with health care, but also investigators in life sciences, biotech companies, graduate students and many others who are interested in more applied aspects of epigenetics. Research in the area of translational epigenetics is a cornerstone of this volume. Critical reviews dedicated to the burgeoning role of epigenetics in medical practice Coverage of emerging topics including twin epigenetics as well as epigenetics of gastrointestinal disease, muscle disorders, endocrine disorders, ocular medicine, pediatric diseases, sports medicine, noncoding RNA therapeutics, pain management and regenerative medicine Encompasses a disease-oriented perspective of medical epigenetics as well as diagnostic and prognostic epigenetic approaches to applied medicine
Behcet's disease is a multisystem inflammatory disease with unknown etiology and has a unique geographic distribution. It is characterized by recurrent oral aphthous lesions, recurrent uveitis, skin lesions, and genital ulcerations. However, it may involve the eye, joints, and cardiovascular, gastrointestinal, and neurological systems at varying degrees as well as the skin and mucous membranes. The disease may manifest itself in a wide spectrum of symptoms ranging from mild symptoms to life-threatening symptoms or severe symptoms that may create permanent sequelae. Knowing the nature of the disease will make it easier to diagnose and manage the disease. This book was written by expert authors, and detailed epidemiology, etiopathogenesis, mucocutaneous findings, and systemic involvement of Behcet's disease are presented to readers.
Focusing on the vital links between neurology and other medical specialties, the new edition of this uniquely interdisciplinary work presents an authoritative guide to the neurological aspects of general medical disorders, and to some of the medical complications of neurological diseases. This third edition is completely revised and updated, with generous illustrations and an extensive list of references.
This Open Access book presents practical approaches to managing patients affected by various rheumatological diseases, allowing readers to gain a better understanding of the various clinical expressions and problems experienced by these patients. Discussing rheumatology from an organ systems perspective, it highlights the importance ofdetailed musculoskeletal examinations when treating patients affected by rheumatological diseases. The book first explores the latest diagnostic approaches and offers key tips for accurate musculoskeletal examinations before addressing the various treatment modalities, with a particular focus on the most common joints involved in rheumatoid arthritis: the wrists and the metacarpophalangeal joints (2nd and 3rd). Featuring easy-to-understand flow diagrams and explaining the common medical problems associated with rheumatic disease, such as shortness of breath and anemia, it is not only a valuable resource to rheumatologists, but will also appeal to medical students, junior residents, and primary healthcare physicians.