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The second edition, which appears seven years after the first, is a more comprehensive text and addresses the many recent advances in basic and clinical science applicable to autoimmune hepatitis, primary biliary cirrhosis, primary sclerosing cholangitis, and autoimmune aspects of viral-, drug- and alcohol-induced liver disease and hepatocellular cancer. Pathogenesis, diagnosis and treatment are discussed in depth in light of current understanding of the molecular mechanisms of autoimmunity as it applies to liver disease.
Ein praxisorientierter Leitfaden zu autoimmunen Lebererkrankungen, Pathogenese, Diagnose und Management. Autoimmune Liver Disease Management and Clinical Practice erläutert alles Wissenswerte zum aktuellen Forschungsstand autoimmuner Lebererkrankungen und legt dabei den Schwerpunkt auf Diagnose und Behandlung. Nach einer ausführlichen Darstellung der heutigen Erkenntnisse in der Immunologie in Verbindung mit der Autoimmunität der Leber werden die vier wichtigsten autoimmunen Lebererkrankungen bei Erwachsenen und Kindern erläutert, einschließlich Management, Rolle von Lebertransplantationen, erprobte Ansätze des Patientenmanagements und Empowerment-Ansätze. Die Autoren, Experten des Fachgebiets, untersuchen im Detail autoimmune Lebererkrankungen und geben Kliniker Handreichungen zur Patientenunterstützung. Die folgenden Themenkomplexe werden unter anderem ausführlich behandelt: - Die vier autoimmunen Lebererkrankungen, deren Diagnose und Behandlungsoptionen. - Einsatz (und Missbrauch) von Autoantikörpern bei Diagnose und Behandlung. - Rolle und Zeitpunkt von Lebertransplantationen und die Auswirkung auf wiederkehrende autoimmune Lebererkrankungen und De-novo-Autoimmunhepatitis. - Optimales Patientenmanagement und patientenbezogene Pflege. Dieses Referenzwerk zeigt umfassend, im Detail und mit alltäglichem Praxisbezug die jüngsten Entwicklungen beim Management von Lebererkrankungen und richtet sich an Ärzte, Pflegepersonal und Experten im Gesundheitswesen.
Drug-Induced Liver Injury, Volume 85, the newest volume in the Advances in Pharmacology series, presents a variety of chapters from the best authors in the field. Chapters in this new release include Cell death mechanisms in DILI, Mitochondria in DILI, Primary hepatocytes and their cultures for the testing of drug-induced liver injury, MetaHeps an alternate approach to identify IDILI, Autophagy and DILI, Biomarkers and DILI, Regeneration and DILI, Drug-induced liver injury in obesity and nonalcoholic fatty liver disease, Mechanisms of Idiosyncratic Drug-Induced Liver Injury, the Evaluation and Treatment of Acetaminophen Toxicity, and much more. - Includes the authority and expertise of leading contributors in pharmacology - Presents the latest release in the Advances in Pharmacology series
Explore this practical and step-by-step guide to managing liver transplant patients from leading international clinicians in Hepatology The newly revised Second Edition of Liver Transplantation: Clinical Assessment and Management delivers expert clinical guidance on best practices in managing the care of liver transplant patients. Authors are all experts in their field and cover a world-wide perspective. Organized in an accessible, stepwise fashion and packed with text features such as key points, the book covers all critical areas of each stage of the liver transplant journey, from assessment, to management on the list, to long term care. Readers will learn when to refer a patient for liver transplantation, how to assess a potential liver transplant recipient, learn the principles of the procedure and the long term management of the transplant recipient. Liver Transplantation provides the entire hepatology and surgical team the information required for a sound understanding of the entire procedure, from pre- to post-operative care and management. Clinically oriented and management-focused, the book is far more accessible than the liver transplant sections in traditional hepatology textbooks. Readers will also enjoy: A thorough discussion of when to refer a patient for liver transplantation, including general considerations and the use and abuse of prognostic models An exploration of the selection, assessment, and management of patients on the transplant list, including how to manage a patient with chronic liver disease while on the waiting list A treatment of liver transplantation for acute liver failure (ALF), including assessment and management of ALF patients on the transplant waiting list A discussion of care of the liver transplant recipient after the procedure in the short and long term Perfect for gastroenterologists, hepatologists, and surgeons and other health care professionals managing patients with liver disease who are awaiting, undergoing and following liver transplantation, Liver Transplantation: Clinical Assessment and Management will also earn a place in the libraries of medical students, residents, internal medicine physicians, and GI/Hepatology trainees and all health care professionals providing clinical care to people with liver disease, before, during and after transplantation.
The Digestive System in Systemic Autoimmune Diseases represents the state-of-the-art in the field of digestive disorders in the most common systemic autoimmune diseases.The volume consists of an introductory chapter on imaging techniques in digestive diseases, followed by eight chapters on digestive manifestations in specific systemic autoimmune diseases. The final five chapters deal with digestive diseases with an autoimmune pathogenesis and systemic manifestations.International in scope, the table of contents reads like a Who's who in clinical research on systemic autoimmune diseases. More than 20 contributors from the European Union, the United States, Mexico and South Africa share their knowledge in this detailed volume.*One book of leading international clinical and scientific experts on autoimmune and digestive diseases*A practical guide to the identification, diagnosis and treatment of digestive involvement in patients with autoimmune diseases that will be useful for all medical specialties*Several diseases and conditions not included in other text books are included, some of which are of recent emergence*Each chapter is designed to serve as a "Guide to Clinical Practice for each disease
This clinical casebook provides a concise yet comprehensive state-of-the-art review of liver disease. Presented in a case-based format, each case features a scenario centered on a different variant of liver disease, with sections on case history, diagnosis/assessment, treatment, outcomes, alternative approaches, and clinical pearls. Diseases covered include drug-induced liver injury, acute hepatitis, chronic hepatitis, NAFLD, and cholangitis. Scenarios such as liver disease in pregnancy, elevated liver function tests, and liver transplants are also presented in the casebook. Written by experts in the field, Liver Disease: A Clinical Casebook is a valuable resource for clinicians and practitioners who treat patients with liver disease.
Of the two disciplines in parallel development for two decades, tumor immunology and transplantation immunology, the latter has thrived and has led to some of the most critical discoveries in immunobiology. The former continues to thwart both scientists and clinicians alike.The goal of immunologists in modern day research is to develop a simple and effective means to manipulate cancer in vivo, possibly encompassing several venues: identifying a phenotypic marker and the use of either active or passive immunization; include the use of passive reagents carrying "warheads" to selectively destroy cancer cells; or altering the basic process of cell survival.This excellent multidiscipline-authored volume presents a theme which has not been well described before. The papers include both basic and clinical science and range from sophisticated molecular biology to little more than phenomenology (e.g. the increased association of cancer in some autoimmune diseases and increased presentation of autoimmune phenomena in malignant condition). This, however, is state-of-the-art.This collection of themes will be of use not only to bench scientists, but also to clinicians who treat patients. The book represents progress at the cutting edge of this discipline, and points the way to further developments in the "black box" of immunology.
Liver disease is a rapidly growing speciality, and nurses and health care professionals need to have the relevant knowledge and skills to care for patients with liver problems in a safe and effective way. Liver Diseases is a comprehensive, evidence-based, practical guide to the nursing care and management of patients with liver disease. Liver Diseases explores a range of liver conditions, including cirrhosis, portal hypertension, alcoholic liver disease, viral hepatitis, autoimmune hepatitis, Wilson’s disease and acute liver failure. It looks at the anatomy & physiology of the liver, assessment of liver function and diagnostic studies, acute and chronic liver disease, pregnancy related liver disease, liver transplantation and infectious liver diseases. For each condition the epidemiology, complications and nursing management are provided, along with illustrative case studies and further reading. Liver Diseases is an invaluable tool for all nurses and health care professionals working with people with liver disease. SPECIAL FEATURES The first UK book on care of the liver from a nursing and healthcare perspective Written by a well-respected and renowned author in the field Covers a wide spectrum of liver diseases, with relevant nursing management guidelines With case studies, further reading and illustrations throughout
Completely revised new edition of the premier reference on pediatric liver disease. Liver Disease in Children, 3rd Edition provides authoritative coverage of every aspect of liver disease affecting infants, children, and adolescents. The book offers an integrated approach to the science and clinical practice of pediatric hepatology and charts the substantial progress in understanding and treating these diseases. Chapters are written by international experts and address the unique pathophysiology, manifestations, and management of these disorders in the pediatric population. The third edition has been thoroughly updated and features new contributions on liver development, cholestatic and autoimmune disorders, fatty liver disease, and inborn errors of metabolism. With the continued evolution of pediatric hepatology as a discipline, this text remains an essential reference for all physicians involved in the care of children with liver disease.
This book is the first to provide balanced examination of both pediatric liver disease and liver transplantation – two topics that are inherently related, given that most chronic liver disorders eventually require organ replacement. The different forms of liver disease encountered in the pediatric age group are first discussed in a series of disease-specific chapters that have a reader-friendly, uniform structure covering pathophysiology, diagnostic and treatment algorithms, clinical cases, and transition to adult care. Key topics in the field of liver transplantation are then addressed. Examples include indications and contraindications, surgical techniques and complications, immunosuppression, in pediatric liver transplantation, acute and chronic rejection and allograft dysfunction, and CMV and EBV infection in transplant recipients, long-term graft injury and tolerance. A section on pediatric hepatology across the world includes chapters presenting the features and management of pediatric liver disease in South-America, Africa and Asia. A closing section considers what the future holds for pediatric liver disease and its management, including novel genetic testing, cell therapy and gene therapy. Pediatric Hepatology and Liver Transplantation will be of value for a range of practitioners, from residents making their first approach to pediatric liver disease through to specialists working in transplantation centers.