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Efferent sensory systems have emerged as major components of processing by the central nervous system. Whereas the afferent sensory systems bring environmental information into the brain, efferent systems function to monitor, sharpen, and attend selectively to certain stimuli while ignoring others. This ability of the brain to implement these functions enables the organism to make fine discriminations and to respond appropriately to environmental conditions so that survival is enhanced. Our focus will be on auditory and vestibular efferents, topics linked together by the inner ear connection. The biological utility of the efferent system is striking. How it functions is less well understood, and with each new discovery, more questions arise. The book that is proposed here reflects our vision to share what is known on the topic by authors who actually have made the observations.
Development of Auditory and Vestibular Systems fourth edition presents a global and synthetic view of the main aspects of the development of the stato-acoustic system. Unique to this volume is the joint discussion of two sensory systems that, although close at the embryological stage, present divergences during development and later reveal conspicuous functional differences at the adult stage. This work covers the development of auditory receptors up to the central auditory system from several animal models, including humans. Coverage of the vestibular system, spanning amphibians to effects of altered gravity during development in different species, offers examples of the diversity and complexity of life at all levels, from genes through anatomical form and function to, ultimately, behavior. The new edition of Development of Auditory and Vestibular Systems will continue to be an indispensable resource for beginning scientists in this area and experienced researchers alike. Full-color figures illustrate the development of the stato-acoustic system pathway Covers a broad range of species, from drosophila to humans, demonstrating the diversity of morphological development despite similarities in molecular processes involved at the cellular level Discusses a variety of approaches, from genetic-molecular biology to psychophysics, enabling the investigation of ontogenesis and functional development
Six studies explore how signals going from the brain to parts of the auditory system helps the system perform a number of functions, including adapting to background noise and allowing transients and other brief stimuli to be properly coded. Studies include discussions of the olivocochlear system and protection from acoustic injury, ontogenetic and evolutionary evidence for the motoneuron nature of vestibular and cochlear efferents, de-recruitment by multiband compression in hearing aids, and clinical applications. The CD contains a brief video of hair cell control and damping.
Vestibular physiology has acquired new interest in the past few years. The development of fast aircraft, beginning during the Second World War and continuing through modern supersonic jets and space travel, has increased dramatically the acceleration range to which man is subjected, from prolonged weightlessness to several gs. The labyrinth measures all kinds of acceleration, including gravity. and therefore has taken on particular impor tance in the study of human health in the Space Age. It is understandable. then, that NASA sponsored the Symposium on Vestibular Function and Morphology. a satellite of the Eighth Annual Meeting of the Society of Neuroscience. held October 30-November 1. 1978, at the University of Pittsburgh, which also supported the symposium. The present volume was developed from papers originally presented there. My strategy in editing this book has been to focus upon the vestibular end organ and its direct connections. both peripheral and central, in order to as sure a coherent discussion of the basics of vestibular function, structure, and ultrastructure. Fortunately, it was possible to secure the contributions of a number of outstanding investigators from both the United States and abroad, including functionally oriented morphologists. ultrastructuralists, biophysicists, and vestibular physiologists. The result is a comprehensive discussion of the main mechanisms of the labyrinth: the transduction pro cess at the receptor level, in the semicircular canals, and in the utricular and saccular maculae; the information transfer through neuronal pathways to the nuclei and the cerebellum; and the general organization of the system.
The Springer Handbook of Auditory Research presents a series of comp- hensive and synthetic reviews of the fundamental topics in modern au- tory research.The volumes are aimed at all individuals with interests in hearing research, including advanced graduate students, postdoctoral researchers, and clinical investigators.The volumes are intended to int- duce new investigators to important aspects of hearing science and to help established investigators to better understand the fundamental theories and data in ?elds of hearing that they may not normally follow closely. Each volume is intended to present a particular topic comprehensively, and each chapter will serve as a synthetic overview and guide to the lit- ature.As such, the chapters present neither exhaustive data reviews nor original research that has not yet appeared in peer-reviewed journals.The volumes focus on topics that have developed a solid data and conceptual foundation rather than on those for which a literature is only beginning to develop. New research areas will be covered on a timely basis in the series as they begin to mature.
"The role of the vestibular efferent system is presently unknown, but evidence based on physiological similarities with the auditory efferent system suggest that it may mediate vestibular end organ development - potentially altering transmission of vestibular information by afferents. To investigate the role of the efferent system, I characterized gaze stabilization and postural control pathways in transgenic mice lacking mediators of efferent signaling ([alpha]-9 and/or [alpha]CGRP). I found that loss of [alpha]-9 attenuated VOR gain, particularly at 4.0HZ, and loss of [alpha]CGRP caused motor deficits during both rotarod and balance beam tasks, consistent with the role of efferents in inner ear development. Finally, to directly assess how loss of cholinergic efferent signaling might influence information transmission I developed methods to record from vestibular afferents of 129SvEv mice during both sinusoidal and random noise stimulation. I found that afferent sensitivity and phase were comparable between both stimulus paradigms, with higher sensitivity and phase lead in afferents with more irregular spontaneous discharge. In contrast, computations of coherence and mutual information revealed that afferents with more regular spontaneous discharge encoded more information content over the natural frequency range of head motion in mice (≤4.0Hz; Beraneck et al., 2008). Taken together, the results suggest this approach will be useful in characterizing changes in sensory information coding in transgenic mice with an impaired efferent system. Overall, my research provides insight into vestibular efferent function and presents future directions for better understanding the underlying physiological changes that occur when this pathways is impaired." --
The Springer Handbook of Auditory Research presents a series of compreh- sive and synthetic reviews of the fundamental topics in modern auditory - search. The volumes are aimed at all individuals with interests in hearing research including advanced graduate students, postdoctoral researchers, and clinical investigators. The volumes are intended to introduce new investigators to important aspects of hearing science and to help established investigators to better understand the fundamental theories and data in ?elds of hearing that they may not normally follow closely. Each volume presents a particular topic comprehensively, and each serves as a synthetic overview and guide to the literature. As such, the chapters present neither exhaustive data reviews nor original research that has not yet appeared in peer-reviewed journals. The volumes focus on topics that have developed a solid data and conceptual foundation rather than on those for which a literature is only beginning to develop. New research areas will be covered on a timely basis in the series as they begin to mature.