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The number of solid organ transplant recipients is increasing worldwide every year, which has meant a significant improvement of recipient’s survival and quality of life. To prevent graft rejection, patients require long-term immunosuppression, which is responsible for their increased risk of neoplastic and infectious diseases. This practical and concise atlas presents the most important dermatoses in solid organ transplant recipients. Providing a guide to diagnosis and appropriate therapy, it helps dermatologists, general practitioners and physicians manage the dermatoses found in organ transplant recipients. The first three chapters discuss immunosuppressive regimens and the prevalence of dermatoses, while the other chapters approach the main diseases didactically, providing a large number of illustrations.
Organ transplantation has been successfully performed over the last 35 years and the number of organ allograft recipients is steadily increasing. Long-term immunosuppression, necessary for good graft function, inevitably induces undesired effects (particularly infectious and neoplastic ones) among which cutaneous ones are very frequent and potentially life-threatening. This book deals with all aspects of cutaneous disorders that may be encountered in the setting of organ transplantation. It reflects the pioneering work performed since long by Dermatologists in Lyon, in collaboration with teams specialised in kidney, heart, lung, liver and pancreas transplantation.
Organ transplantation has been performed for almost 40 years with steadily increasing success regarding long-time survival of the graft, as well as quality of life for the patient. However, graft tolerance only can be achieved via induction and maintenance of an impaired immunological surveillance. An increase of skin cancers as a consequence of the lowered cellular immunoresponse seems to parallel the overall increased long-time survival rate of organ transplant recipients. Against the background of chronic immunosuppression known risk factors like the amount of sun exposure prior and post transplantation, oncogenic viruses as well as the genetic background, and place of residence (latitude) are strongly related with the increased skin cancer incidence. The increasing incidence of non-melanoma skin cancer, paralleling a prolonged survival of patients after organ transplantation, represents a significant reason for morbidity and long-term morbidity in organ transplant recipients worldwide. The incidence of non-melanoma skin cancer in liver-, kidney- and heart transplant recipients varies from 1.5 to 22 %, 2 to 24 % and 6 to 34 % after 5 years post transplant. Ultraviolet radiation as well as immunosuppressive therapy are crucial risk-factors regarding the induction and progression of skin cancer. Ultraviolet radiation is related to the induction of DNA damage, as well as interference with Langerhans cell antigen presentation and a Th1 – Th2 shift induced via a release of IL-10. Whereas the overall duration of immunosuppression and the cumulative dosage applied are relevant parameters in the evaluation of an increased tumor risk, individual differences between specific immunosuppressive agents remain unclear. The workup of genetic as well as other unclear phenomenon like the reverse BCC/SCC ratio might shed some further light into the genesis and immunology of the non-melanoma skin cancer in general.
Dermatology is the science responsible for the study of the skin, mucous membranes (oral and genital) and cutaneous appendages, while dermatopathology focuses on its microscopic study. Although the two fields are closely related, in many cases the identification of dermatological diseases is mainly clinical and depends on the physician’s ability and experience. The purpose of this atlas, which collects over 900 clinical and histological photographs in high resolution, is to illustrate and describe the most frequent skin diseases on the basis of clinical cases. Offering a complete guide to the etiology, epidemiology, clinical features, histologic findings and diagnosis of the main skin diseases divided into three subgroups (inflammatory, infectious, or tumoral), it represents an invaluable resource for all medical students, residents, clinicians, and investigators learning dermatology.
Highly illustrated and conveniently templated for quick reference, Atlas of Liver Pathology, 4th Edition, is a useful Atlas and text for every practicing pathologist or trainee who assesses liver biopsy specimens. From cover to cover, it contains all the information needed to identify histologic features and correlate them with clinical findings, offering a clearer understanding of the clinical implications of the disease as it relates to treatment. More than 1,200 high-quality, full-color images and illustrations provide you with a complete visual guide to the vast majority of liver diseases and assist in the diagnoses of biopsy and resected liver specimens. Provides clear, templated information for each disease: Major Morphologic Features; Special Stains; Differential Diagnoses; Clinical and Biologic Behavior; and Treatment and Prognosis. Incorporates relevant data from ancillary techniques (immunohistochemistry, cytology, cytogenetics and molecular genetics), giving you the necessary tools required to master the latest breakthroughs in diagnostic technology. Incorporates the latest diagnostic biomarkers and their utility in differential diagnoses, newly described variants, and new histologic entities. Contains two new chapters on liver biopsy interpretation and autoimmune hepatitis. Features concise, bulleted text and abundant tables that cover common as well as rare diseases, differential diagnoses, and more.
An extremely practical text, this new edition of Diseases of the Liver and Biliary System in Children covers the essentials of paediatric hepatology. The range of material is wide and has been revised and updated to include the latest advances. Many helpful algorithms and tables are included and the references at the end of each chapter have been carefully selected so as to provide the most up-to-date information available. A concluding section comprising some 100 carefully annotated plates, completes this text. Containing the contributions of 23 internationally acclaimed authorities, active both clinically and in research, the book provides an essential guide to the diagnosis and management of paediatric liver diseases, both common and uncommon for all those involved in the care of the child with liver disease. Diseases of the Liver and Biliary System in Children has become THE REFERENCE of choice for the paediatric gastroenterologist, hepatologist and surgeon.
Needle biopsy of the liver is now an accepted procedure in most large hospitals, and surgeons and laparoscopists are more likely to biopsy the liver under direct vision than in the past. Consequently, increasing demands are being made on pathologists for rapid diagnosis. This full colour atlas provides a practical guide to the histopathological diagnosis of liver disorders, with particular emphasis on clinicopathological correlation and the need for the pathologist to be in full possession of all the available clinical information. Although containing over 350 colour illustrations, the book is more than just an atlas and each section includes a brief description of the main clinical and pathological features of the subject under discussion. For this second edition, many chapters have been rewritten - e.g. on viral hepatitis - and many new illustrations added. The book is intended for the practising and trainee pathologist and the clinician who performs liver biopsies, but will also be of value to postgraduates, residents and students in other branches of medicine.
Atlas of Head and Neck Pathology delivers authoritative, highly visual guidance for effectively and accurately diagnosing a wide range of head and neck problems. This comprehensive resource features extensive, high-quality images depicting the histologic, immunohistochemical, cytologic, and diagnostic imaging appearance of every type of head and neck pathology. With a consistent, practical organization and succinct, bulleted format, the Atlas continues to be the resource general pathologists and specialists count on for reliable, easy-to-find answers. Reach accurate diagnostic conclusions easily with a consistent, user-friendly format that explores each entity's clinical features, pathologic features (gross and microscopic), ancillary studies, differential diagnoses, and prognostic and therapeutic considerations. Glean all essential, current, need-to-know information with sweeping revisions that include additional images shown in the frozen section, more content on odontogenic lesions and neoplasms, and inclusion of newly described entities such as igG-associated salivary gland diseases, mammary analog secretory carcinoma, and more. Review expanded coverage of critical areas with additional chapters on oral cavity and oropharynx, nasopharynx, and neck. Apply the most current staging of cancers from College of American Pathologists (TNM) and American Joint Committee on Cancer (AJCC). Interpret the findings you're likely to see in practice with the aid of high-quality images now available online for review or download. Take it with you anywhere! With Expert Consult, you'll have access to the full text, online, and as an eBook - at no additional cost!
This issue of the Atlas of the Oral and Maxillofacial Surgery Clinics, edited by Dr. Joel J. Napeñas, focuses on Oral Manifestations of Systemic Diseases. Articles will feature Evaluation of the Patient; Oral Manifestations of Gastrointestinal Disorders; Oral Manifestations of Immunodeficiencies and Transplantation Medicine; Oral Manifestations of Autoimmune and Connective Tissue Disorders; Oral Manifestations of Drug-induced Disorders; Oral Manifestations of Neurologic Disorders; Oral Complications of Nonsurgicial Cancer Therapies; Oral Complications of Hematologic Disorders; Oral Complications of Systemic Viral Infections; Oral Complications of Allergies and Immunologically Mediated Diseases; Oral Complications of Multi-Organ Disorders; Oral Complications of Endocrine Disorders; Oral Complications of Systemic Bacterial and Fungal Infections; Dental and Periodontal Manifestations of Systemic Disease; Oral Complications of Dermatologic Disorders, and more!