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The substitution of fluorine in an organic molecule increases its chemical stability and changes its reactivity, sometimes leading to substantially more effective medicines, pesticides, and herbicides. This book collects current work on the synthesis of these compounds.
In this handbook, Peer Kirsch clearly shows that this exciting field is no longer an exotic area of research. Aimed primarily at synthetic chemists wanting to gain a deeper understanding of the fascinating implications of including the highly unusual element fluorine in organic compounds, the main part of the book presents a wide range of synthetic methodologies and the experimental procedures selected undeniably show that this can be done with standard laboratory equipment. To round off, the author looks at fluorous chemistry and the applications of organofluorine compounds in liquid crystals, polymers and more besides. This long-awaited book represents an indispensable source of high quality information for everyone working in the field.
Written by a leading expert in the field, this is a comprehensivereview of the methods for preparing stereochemically definedfluorine-containing compounds of biomedical importance. Fluorinated organic compounds are well known for their unusualreactivity but the growing importance of these compounds in thebiomedical field has been accompanied by an increasing awareness ofthe necessity to synthesise and explore the biological propertiesof stereochemically defined fluoro-compounds. This is the firstbook written on this exciting area of research. It contains: * detailed reviews on stereocontrolled synthesis of biologicallyimportant compounds * 21 chapters covering the main areas of asymmetric synthesis andbiocatalysts where fluorine plays a key role * mechanisms and methods for synthesizing fluoro-organiccompounds Written for professionals involved in organic, physical andorganofluorine chemistry, natural product synthesis, biological,pharmaceutical and other life science related industries.
The book contains 30 top-notch chapter-reviews on recent methodological developments in the area of synthetic fluoro-organic chemistry, Fluorous technology, and biological applications of fluorinated compounds. Special emphases are given to the synthesis of biologically relevant compounds (alcohols, amines, alpha- and beta-amino acids, peptides), industrial-scale production of highly versatile, synthetically useful fluorinated synthons, as well Fluorous technology. The book has been designed to be a comprehensive snap-shot of current research activity in the field reviewed by internationally renowned leading experts from academic and industrial laboratories around the world. The topics covered in the book range from synthesis of small fluorinated molecules to peptides and macromolecules for crystal engineering. Substantial amount of data reviewed in the book have never been published. In particular cutting-age Fluorous technology, summarized in the book, will give the reader unprecedented prospective on new separation methods which will be on market in the nearest future. Taking into account the significant impact that fluorinated compounds have made on nearly all aspects of modern life this book is expected to be a current prime reference in the field and might be of interest to diverse readership.
The book contains 35 top-notch chapter-reviews on recent methodological developments in the area of synthetic fluoro-organic chemistry based on fluorinated synthons approach. Special emphases are given to the synthesis of biologically relevant compounds (alcohols, amines, alpha- and beta-amino acids, peptides), industrial-scale production of highly versatile, synthetically useful fluorinated synthons, as well as asymmetric synthesis of fluorinated synthons. The book has been designed to be a comprehensive snap-shot of current research activity in the field reviewed by internationally renowned leading experts from academic and industrial laboratories around the world. The topics covered in the book range from synthesis of small fluorinated molecules to peptides and macromolecules for crystal engineering. Substantial amount of data reviewed in the book have never been published. In particular cutting-age technology from industrial laboratories, summarized in the book, will give the reader unprecedented prospective on commercial availability of variety of structurally diverse fluorinated synthons which will be on market in the nearest future. Taking into account the significant impact that fluorinated compounds have made on nearly all aspects of modern life this book is expected to be a current prime reference in the field and might be of interest to diverse readership.
In this most up-to-date handbook each chapter contains a general introduction, followed by the principles of the immobilization and, finally, applications. In this way, it covers the most important approaches currently employed for the heterogenization of chiral catalysts, including data tables, applications, reaction types and literature citations. For chemists in both academia and industry as well as those working in the fine chemical and pharmaceutical industry.
This volume brings together contributions by leading researchers covering a wide scope so characteristic of fluorine chemistry. It is a monograph of historical character comprising personalized accounts of progress and events in areas of particular interest. There is also much to interest and instruct chemists from other disciplines as a good proportion of the chapters contain a considerable amount of 'hard' referenced information relating to modern organic, organoelemental and inorganic chemistry. Historians of chemistry and technology will no doubt be tempted to dip into this book, and surely whoever addresses the task of commemorating Moissan's achievement at the 150-years stage will bless us all in some measure for its existence.
Recently there has been a tremendous growth in the chemistry of fluoroorganic compounds, which find wide applicatiori in various fields of technique and are used to solve some basic theoretical problems. The chemical properties of these compounds are rather specific, as well as the methods for their preparation. We realized that no good handbooks on the preparation offluoro organic compounds were available, whereas the methods of pre paration are scattered in numerous scientific papers and patents. Even such a well-known publication as Organic Syntheses contains just a few methods of preparation of fluoroorganic compounds. As a consequence, not only for newcomers but even for specialists, searching for simple and convenient methods for the preparation of the required compounds is tedious. To alleviate the problem, we undertook to prepare this book, which presents detailed preparation methods of more than 300 flu oro organic compounds. Emphasis has been laid on syntheses of polyfluorinated compounds, since they are of major interest with respect to preparation and utility. Preparation of fluoroorganic compounds is based both on the classical methods of organic chemistry and on the specific ones, which is due to the difficulty or even impossibility of the direct introduction of fluorine into a definite position of organic mole cule. Most organic compounds of fluorine are prepared by a suc cession of conversions of a relatively small number of starting compounds.
In recent years, organo-fluorine chemistry has made a marked impact on the design and synthesis of a large variety of biologically active molecules, such as steroids, carbohydrates, amines, amino acids, peptides and other natural products. Naturally occurring amino acids play a pivotal role in living systems, and therefore synthetic fluorine-containing amino acids have been of significant interest to researchers working towards the understanding and modification of physiological processes. Fluorine-containing Amino Acids: is the first volume devoted to the synthesis and properties of fluorine-containing amino acids pays special attention to the preparation of enantiomerically pure acids (which are essential to the modern pharmaceutical industry) deals with a rapidly expanding field of research has been written by experienced researchers who are responsible for many developments in the field highlights the interdisciplinary nature of this topic Fluorine-containing Amino Acids is the only dedicated reference in this subject and will be essential for researchers in synthetic organic, peptide, natural product, and medicinal chemistry and biochemistry.