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Deterministic safety analysis is an important tool for confirming the adequacy and efficiency of provisions within the defence in depth concept for the safety of nuclear power plants (NPPs). IAEA Safety Standards Series No. NS-R-1.2 and Safety Reports Series No. 23 recommend, as one of the options for demonstrating the inclusion of adequate safety margins, the use of best estimate computer codes with realistic input data in combination with the evaluation of uncertainties in the calculation results. The evaluation of uncertainties is an issue of considerable complexity, and this Safety Report has been developed to complement the existing publications. It provides more detailed information on the methods available for the evaluation of uncertainties in deterministic safety analysis of NPPs and practical guidance in the use of these methods.