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In this timely and much praised book, Barry Werth draws upon inside reporting that spans more than two decades. He provides a groundbreaking close-up of the upstart pharmaceutical company Vertex and the ferocious but indispensable world of Big Pharma that it inhabits. In 1989, the charismatic Joshua Boger left Merck, then America’s most admired business, to found a drug company that would challenge industry giants and transform health care. Werth described the company’s tumultuous early days during the AIDS crisis in The Billion-Dollar Molecule, a celebrated classic of science and business journalism. Now he returns to tell a riveting story of Vertex’s bold endurance and eventual success. The $325 billion-a-year pharmaceutical business is America’s toughest and one of its most profitable. It’s riskier and more rigorous at just about every stage than any other business, from the towering biological uncertainties inherent in its mission to treat disease; to the 30-to-1 failure rate in bringing out a successful medicine even after a molecule clears all the hurdles to get to human testing; to the multibillion-dollar cost of ramping up a successful product; to operating in the world’s most regulated industry, matched only by nuclear power. Werth captures the full scope of Vertex’s twenty-five-year drive to deliver breakthrough medicines. At a time when America struggles to maintain its innovative edge, The Antidote is a powerful inside look at one of the most intriguing and important business stories of recent decades.
Chronic pain is not a life sentence If you are one of the 100 million people who suffer from chronic pain, you may be feeling hopeless and helpless, relying on endless medications that don't work, feeling worse and worse. But there is hope -- and help. The innovative program at the acclaimed Las Vegas Recovery Center, at which Dr. Mel Pohl is Medical Director, has helped thousands of sufferers to reduce chronic pain without the use of painkillers. The Pain Antidote shares this program's concrete tools and strategies, offering: Cutting-edge research on how pain affects your brain How your emotions affect your experience of pain A comprehensive program, including a four-week Jump Start plan Pain-reducing gentle exercises and health-supporting foods And much more.
The first source on insomnia treatment since the advancement of newer drug options and cognitive behavioral therapies, Insomnia: Diagnosis and Treatment presents a comprehensive reference on the complications, evaluation, and treatment of insomnia. Ideal for sleep medicine specialists, psychiatrists, and neurologists, this text uses a multi-discipl
In this whip-smart and timely novel from acclaimed author Kimmery Martin, two doctors travel a surprising path when they must choose between treating their patients and keeping their jobs. Georgia Brown’s profession as a urologist requires her to interact with plenty of naked men, but her romantic prospects have fizzled. The most important person in her life is her friend Jonah Tsukada, a funny, empathetic family medicine doctor who works at the same hospital in Charleston, South Carolina and who has become as close as family to her. Just after Georgia leaves the country for a medical conference, Jonah shares startling news. The hospital is instructing doctors to stop providing medical care for transgender patients. Jonah, a gay man, is the first to be fired when he refuses to abandon his patients. Stunned by the predicament of her closest friend, Georgia’s natural instinct is to fight alongside him. But when her attempts to address the situation result in incalculable harm, both Georgia and Jonah find themselves facing the loss of much more than their careers.
What does it mean to move away from the shadow of one’s mother, parents, or family in order to come into being within this world? As collective memory within the Black diaspora has been ruptured, GHETTOCLAUSTROPHOBIA time travels by creating and recapturing memory from a fractured past to survive in the present and envision a future. In her first full-length collection GHETTOCLAUSTROPHOBIA: Dreamin of Mama While Trying to Speak Woman in Woke Tongues, Shanta Lee Gander navigates between formal and vernacular styles to introduce the reader to a myriad of subjects such as scientific facts that link butterflies to female sexuality and vulnerability; whispers of classical Greek myth; H.P. Lovecraft’s fantastical creature, Cthulhu; and the traces of African mythmaking and telling. Beneath the intensity, longing, seeking, wondering, and the ‘tell-it-like-it-is’ voice that sometimes tussles with sadness, there is a movement of sass and a will that refuses to say that it has been broken. Gander leaves a door ajar in this ongoing conversation of the Black female body that walks the spaces of the individual within a collective; the tensions between inherited and hidden narratives; and the present within a history and future that is still being imagined.
Instant New York Times Bestseller! From New York Times bestselling author Brigid Kemmerer comes an electrifying fantasy romance, perfect for fans of Holly Black and Victoria Aveyard. A desperate prince. A daring outlaw. A dangerous flirtation. In the Wilds of Kandala, apothecary apprentice Tessa Cade has been watching people suffer for too long. A mysterious sickness is ravaging the land and the cure, Moonflower Elixir, is only available for the wealthy. So every night, she defies the royal edicts and sneaks out, stealing Moonflower petals and leaving the elixir for those in need. In the palace of Kandala, Prince Corrick serves as the King's Justice, meting out vicious punishments and striking fear into the hearts of agitators and outlaws. Corrick knows he must play this role convincingly--with a shortage of elixir and threats of rebellion looming ever closer, the King's grip on power is tenuous at best, and Corrick knows his brother is the kingdom's best hope for survival. But when an act of unspeakable cruelty brings the royal and the outlaw face to face, the natural enemies are faced with an impossible choice--and a surprising spark. Will they follow their instincts to destroy each other? Or will they save the kingdom together . . . and let that spark ignite?
“A lovely weave of memory and science, great characters and compassionate humor” from the author of Sweat: A History of Exercise (Anne Lamott). We often think of sleep as mere stasis, a pause button we press at the end of each day. Yet sleep is full of untold mysteries—eluding us when we seek it too fervently, throwing us into surreal dream worlds when we don’t, sometimes even possessing our bodies so that they walk and talk without our conscious volition. Delving into the mysteries of his own sleep patterns, Bill Hayes marvels, “I have come to see that sleep itself tells a story.” An acclaimed journalist and memoirist—and partner of the late neurologist Oliver Sacks—Hayes has been plagued by insomnia his entire life. The science and mythology of sleep and sleeplessness form the backbone to Hayes’s narrative of his personal battles with sleep and how they colored his waking life, as he threads stories of fugitive sleep through memories of growing up in the closet, coming out to his Irish Catholic family, watching his friends fall ill during the early years of the AIDS crisis in San Francisco, and finding a lover. An erudite blend of science and personal narrative, Sleep Demons offers a poignant introduction to the topics for which Hayes has since become famous, including art, eros, city life, the history of medical science, and queer identity. “This intimate and beautifully written book brings scientific research alive in a heartfelt and deeply personal narrative.” —The Guardian “Memoir, history, and science come together and apart again in a book that reads very much like a dream.” —Out magazine
A revelatory, moving narrative that offers a harrowing critique of the war on drugs from voices seldom heard in the conversation: drug users who are working on the front lines to reduce overdose deaths When the news began to break (and break) about the impending opioid epidemic, the story was reliably about despair, addiction, and death. As the story developed to include the criminal actions of Big Pharma, and the heartbreak of relatives who had lost loved ones to overdoses, it continued to leave out one vital perspective: that of the drug users fighting to live--and to help others live as well. Across the country, drug users are organizing themselves in response to the growing number of overdose deaths and demanding that addicts be given the same rights as other citizens. Set against the backdrop of the overdose crisis Light Up the Night provides an up-close look at how drug users navigate policies that criminalize them through the ongoing failed war on drugs. It chronicles a growing social change movement led by drug user activists whose goal is to save lives, end stigma, and inspire common sense policy-making. Told from embedded reporting focused on two local activists, Jess Tilley in Massachusetts and Louise Vincent in North Carolina, this is the story of the courageous people stepping in where the government's public health policies have failed, standing on the front lines of the underground effort to help drug users use drugs safely, reduce harms, and live with dignity.