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Responding to an estimated 14 million cases of food-borne disease that occur every year in the United States alone, the Food and Drug Administration and US Department of Agriculture have begun implementing new regulations and guidance for the microbial testing of foods. Similarly, Europe and other regions are implementing stricter oversight, as foodborne pathogens that cause deadly diseases such as e. coli 0157:H7 have raised the stakes everywhere. Food safety scientists have acted on this growing public health risk by developing improved media for the cultivation of bacteria, fungi, and viruses, much of it geared toward specific rapid detection. Reflecting the development of these new media and the latest FDA recommendations, the second edition of the Handbook of Microbiological Media for the Examination of Foodprovides an essential resource for anyone involved with the monitoring of both food production and post-production quality control. Organized alphabetically by medium, the expanded edition of this highly respected handbookincludes – · Descriptions of nearly 1,400 media including those recommended by the FDA, as well as media used elsewhere in the world · Concise and lucid instructions for the preparation and uses of each of the media · Cross-referenced indexing that allows the media to be found by name or specific microorganism of interest · Descriptions of expected results as they apply to microorganisms of importance for the examination of foods · Common synonyms for the various media and listings of compositions, so that alternate media an be effectively employed when needed Compiled by Ronald M. Atlas, a world-renowned researcher and author known for his pioneering work in pathogen detection, the Handbook of Microbiological Media for the Examination of Food, Second Edition, provides microbiologists with an essential tool for safeguarding public health.
Deliver quality healthcare in the most challenging field conditions Full of practical clinical pearls and proven strategies, this indispensible guide shows you how to operate outside your comfort zone and devise effective treatment solutions when the traditional tools (medications, equipment, and staff) are unavailable—or when you need to provide care outside of your specialty. Improvised Medicine is a must for anyone who plans to work in global, disaster, or other resource-poor settings. FEATURES: Simple-to-follow directions, diagrams, and illustrations describe practical techniques and the improvised equipment necessary to provide quality care during crises. Contains improvisations in anesthesia and airway management, dentistry, gynecology/obstetrics, infectious disease/laboratory diagnosis, internal medicine, otolaryngology, pediatrics and malnutrition, orthopedics, psychiatry, and surgery. Also includes basic disaster communication techniques, post-disaster forensics, a model hospital disaster plan, and innovative patient-transport methods. LEARN HOW TO: Make an endotracheal tube in seconds Perform digital-oral and blind-nasotracheal intubations Make plaster bandages for splints/casts Give open-drop ether, ketamine drips, and halothane Use subcutaneous/intraperitoneal rehydration/transfusion Make ORS and standard nutrition formulas Clean, disinfect, and sterilize equipment for reuse Warm blood units in seconds inexpensively Take/view stereoscopic x-rays with standard equipment Quickly and easily stop postpartum hemorrhage Fashion surgical equipment from common items Evacuate patients easily for high-rise hospitals Make esophageal and precordial stethoscopes Quickly improvise a saline lock Make ECG electrode/defibrillator pads and ultrasound gel
This comprehensive reference provides an in-depth discussion on state-of-the-art regulatory science in bioequivalence. In sixteen chapters, the volume explores a broad range of topics pertaining to bioequivalence, including its origin and principles, statistical considerations, food effect studies, conditions for waivers of bioequivalence studies, Biopharmaceutics Classification Systems, Biopharmaceutics Drug Disposition Classification System, bioequivalence modeling/simulation and best practices in bioanalysis. It also discusses bioequivalence studies with pharmacodynamic and clinical endpoints as well as bioequivalence approaches for highly variable drugs, narrow therapeutic index drugs, liposomes, locally acting gastrointestinal drug products, topical products and nasal and inhalation products. FDA Bioequivalence Standards is written by FDA regulatory scientists who develop regulatory policies and conduct regulatory assessment of bioequivalence. As such, both practical case studies and fundamental science are highlighted in these chapters. The book is a valuable resource for scientists who work in the pharmaceutical industry, regulatory agencies and academia as well as undergraduate and graduate students looking to expand their knowledge about bioequivalence standards.
This volume in the 5-Minute Consult series focuses on neurological diseaes and disorders, as well as key symptoms, signs, and tests. Dozens of noted authorities provide tightly organized, practical guidance. Using the famous two-page layout and outline format of The 5-Minute Consult Series, the book provides instant access to clinically-oriented, must-have information on all disorders of the nervous system. Each disease is covered in a consistent, easy-to-follow format: basics (including signs and symptoms), diagnosis, treatment, medications, follow-up, and miscellaneous considerations (including diseases with similar characteristics, pregnancy, synonyms, and ICD coding).
The extremely potent substance botulinum neurotoxin (BoNT) has attracted much interest in diverse fields. Originally identified as cause for the rare but deadly disease botulism, military and terrorist intended to misuse this sophisticated molecule as biological weapon. This caused its classification as select agent category A by the Centers for Diseases Control and Prevention and the listing in the Biological and Toxin Weapons Convention. Later, the civilian use of BoNT as long acting peripheral muscle relaxant has turned this molecule into an indispensable pharmaceutical world wide with annual revenues >$1.5 billion. Also basic scientists value the botulinum neurotoxin as molecular tool for dissecting mechanisms of exocytosis. This book will cover the most recent molecular details of botulinum neurotoxin, its mechanism of action as well as its detection and application.
The Compendium of Methods for the Microbiological Examination of Foods, now in its new, 4th Edition, is the all-inclusive reference for anyone involved in the dynamic fields of processing and testing the safety and quality of foods. Food-borne illnesses comprise a significant public health problem, striking 76 million Americans yearly and killing 5,000, according to estimates by the Centers for Disease Control and Prevention. APHA's Compendium is the authority for food safety testing. The Compendium presents a comprehensive selection of proven testing methods with an emphasis on accuracy, relevance, and reliability. More than 200 experts have reviewed and updated the 64 chapters in this new edition. New material included on meats and meat products. Contents include: general laboratory procedures, including laboratory quality assurance, environmental monitoring procedures, sampling plans, sample collection, shipment, and preparation for analysis; microorganisms involved in processing and spoilage of foods; foods and the microorganisms involved in their safety and quality; indicator microorganisms and pathogens, microorganisms and food safety: foodborne illness; preparation of microbiological materials-media, reagents, and stains; and much more.
Hundreds of High-Quality Images Span the Entire Spectrum of Vascular Disease INCLUDES DVD WITH IMAGE BANK Color Atlas of Vascular Diseases is designed to help you properly identify and manage vascular diseases involving the arterial, venous, and lymphatic system. It offers a clinical and synoptic approach to the full range of diagnostic and therapeutic considerations in vascular diseases. You will find hundreds of state-of-the-art clinical, diagnostic, and interventional images, along with concise, bulleted text detailing the diagnosis and patient management. This unique combination atlas and learning text written by experts in the field, integrates the fields of vascular medicine, vascular surgery, and endovascular therapy in an effective, easy-to-learn fashion. Chapters feature succinct bulleted teaching points combined with photographs of vascular pathology. When appropriate, vivid arteriographic and ultrasonographic images are also included. Topics include: Lower Extremity Arterial Disease Aortic and Upper Extremity Arterial Disease Carotid Artery Occlusive Disease Aneurysmal Disease Non-Atherosclerotic Disorders Arteriovenous Visceral Disease Venous Disease Limb Swelling Vasospastic and Vasculitic Diseases Environmental Diseases Limb Ulcerations
This new resource on managing oncologic emergencies is directed at all health care professionals who care for patients with cancer or survivors. Edited and written by clinician-experts at The University of Texas MD Anderson Cancer Center, the book covers the full range of oncologic emergencies, from cardiac and neurologic to orthopedic to hematologic, and addresses important palliative care, ethical, and Emergency Department considerations. Chapters are structured with busy clinicians in emergent and urgent settings in mind, and each chapter concludes with a series of key practice points and a list of suggested readings for those who wish to delve deeper into a subject. For any clinician facing the increasing number of patients who experience an oncologic emergency, this is an up-to-date, clinically focused, and authoritative resource.