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This report considers the biological and behavioral mechanisms that may underlie the pathogenicity of tobacco smoke. Many Surgeon General's reports have considered research findings on mechanisms in assessing the biological plausibility of associations observed in epidemiologic studies. Mechanisms of disease are important because they may provide plausibility, which is one of the guideline criteria for assessing evidence on causation. This report specifically reviews the evidence on the potential mechanisms by which smoking causes diseases and considers whether a mechanism is likely to be operative in the production of human disease by tobacco smoke. This evidence is relevant to understanding how smoking causes disease, to identifying those who may be particularly susceptible, and to assessing the potential risks of tobacco products.
"The History of Mathematics: An Introduction," Sixth Edition, is written for the one- or two-semester math history course taken by juniors or seniors, and covers the history behind the topics typically covered in an undergraduate math curriculum or in elementary schools or high schools. Elegantly written in David Burton's imitable prose, this classic text provides rich historical context to the mathematics that undergrad math and math education majors encounter every day. Burton illuminates the people, stories, and social context behind mathematics'greatest historical advances while maintaining appropriate focus on the mathematical concepts themselves. Its wealth of information, mathematical and historical accuracy, and renowned presentation make The History of Mathematics: An Introduction, Sixth Edition a valuable resource that teachers and students will want as part of a permanent library.
Empire of the Air tells the story of three American visionaries—Lee de Forest, Edwin Howard Armstrong, and David Sarnoff—whose imagination and dreams turned a hobbyist's toy into radio, launching the modern communications age. Tom Lewis weaves the story of these men and their achievements into a richly detailed and moving narrative that spans the first half of the twentieth century, a time when the American romance with science and technology was at its peak. Empire of the Air is a tale of pioneers on the frontier of a new technology, of American entrepreneurial spirit, and of the tragic collision between inventor and corporation.
Genetic susceptibility refers to how variations in a person’s genes increase or decrease his or her susceptibility to environmental factors, such as chemicals, radiation and lifestyle (diet and smoking). This volume will explore the latest findings in the area of genetic susceptibility to gastrointestinal cancers, focusing on molecular epidemiology, DNA repair, and gene-environment interactions to identify factors that affect the incidence of GI cancers. Topics will include germline susceptibility, including Mendelian patterns of inheritance and gene-environment interactions that lead to cancer etiology.
This fully revised and significantly expanded second edition examines sex and gender differences in the immune system's response to bacterial, viral, and parasitic infections. The volume discusses both common and distinct molecular mechanisms that mediate these differences and illustrates how responses to vaccines may differ between the sexes and in pregnant individuals. Special emphasis is placed on the interplay between hormones and the immune system in the pathogenesis of HIV, SARS-CoV-2, influenza, malaria, tuberculosis, and amebiasis. This second edition includes completely rewritten chapters as well as all new contents. This book is intended for researchers in academia and industry as well as clinicians in the fields of microbiology, immunology, and pharmacology. By expanding knowledge in sex and gender medicine as a basis for developing personalized treatment strategies, the book contributes to UN Sustainable Development Goals 3 (health and well-being) and 5 (gender equality).
A definitive account and analysis of the evolving genocidal violence in Rwanda in 1994, and of the judicial, political, and diplomatic responses to it.
Why was the UN a bystander during the Rwandan genocide? Do its sins of omission leave it morally responsible for the hundreds of thousands of dead? Michael Barnett, who worked at the U.S. Mission to the United Nations from 1993 to 1994, covered Rwanda for much of the genocide. Based on his first-hand experiences, archival work, and interviews with many key participants, he reconstructs the history of the UN's involvement in Rwanda. In the weeks leading up to the genocide, the author documents, the UN was increasingly aware or had good reason to suspect that Rwanda was a site of crimes against humanity. Yet it failed to act. Barnett argues that its indifference was driven not by incompetence or cynicism but rather by reasoned choices cradled by moral considerations. Employing a novel approach to ethics in practice and in relationship to international organizations, Barnett offers an unsettling possibility: the UN culture recast the ethical commitments of well-intentioned individuals, arresting any duty to aid at the outset of the genocide. Barnett argues that the UN bears some moral responsibility for the genocide. Particularly disturbing is his observation that not only did the UN violate its moral responsibilities, but also that many in New York believed that they were "doing the right thing" as they did so. Barnett addresses the ways in which the Rwandan genocide raises a warning about this age of humanitarianism and concludes by asking whether it is possible to build moral institutions.
Updated in a new 6th edition, Communication in History reveals how media has been influential in both maintaining social order and as powerful agents of change. With revised new readings, this anthology continues to be, as one reviewer wrote, "the only book in the sea of History of Mass Communication books that introduces readers to a more expansive, intellectually enlivening study of the relationship between human history and communication history". From print to the Internet, this book encompasses a wide-range of topics, that introduces readers to a more expansive, intellectually enlivening study of the relationship between human history and communication history.
This is an overview of the issues involved in prevention and early detection of colorectal cancer providing up-to-date, practical advice for clinicians. Possible management strategies for those at risk are provided, taking into account the biological principles of colorectal cancer development, epidemiological data and emerging genetic information, as well as social and environmental factors.
Bringing together many of today's key scholars of verbal charming, these essays cover vernacular magical texts and practice from Malaysia to Madagascar, and from England to Estonia. As the most comprehensive collection of research on charms, charmers and charming available in the English language, it forms an essential reader on the topic.