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Lymphatic Structure and Function in Health and Disease serves as a resource book on what has been learned about lymphatic structure, function and anatomy within different organ systems. This is the first book to bring together lymphatic medicine as a whole, with in-depth analysis of specific aspects of lymphatics in different vascular pathologies. This book is a useful tool for scientists, practicing clinicians and residents, in particular, those in vascular biology, neurology, cardiology and general medicine. Chapters discuss topics such as ontogeny and phylogeny of lymphatics, lymphatic pumping, CNS lymphatics, lymphatics in transplant and lymphatic reconstruction. - Brings together lymphatic medicine as a whole, with an in-depth analysis of the specific basic science aspects of lymphatic structure and function - Covers the clinical aspects of lymphatics in different vascular pathologies - Co-published with the International Society of Neurovascular Diseases - Discusses lymphatic structure and function in all of the major organ systems
This multidisciplinary textbook is designed to be the standard on the subject and is geared for use by physicians who are involved in the care and/or diagnosis of cancer patients. Comprehensive coverage is provided on all aspects of radioguided surgery. Practical information is readily accessible and throughout there is an emphasis on improved decision making. Tables present the indications, performance, and interpretation of procedures at a glance. A wealth of illustrations, including a full-color insert, enhances the application of new concepts.
The partition of fluid between the vascular and interstitial compartments is regulated by forces (hydrostatic and oncotic) operating across the microvascular walls and the surface areas of permeable structures comprising the endothelial barrier to fluid and solute exchange, as well as within the extracellular matrix and lymphatics. In addition to its role in the regulation of vascular volume, transcapillary fluid filtration also allows for continuous turnover of water bathing tissue cells, providing the medium for diffusional flux of oxygen and nutrients required for cellular metabolism and removal of metabolic byproducts. Transendothelial volume flow has also been shown to influence vascular smooth muscle tone in arterioles, hydraulic conductivity in capillaries, and neutrophil transmigration across postcapillary venules, while the flow of this filtrate through the interstitial spaces functions to modify the activities of parenchymal, resident tissue, and metastasizing tumor cells. Likewise, the flow of lymph, which is driven by capillary filtration, is important for the transport of immune and tumor cells, antigen delivery to lymph nodes, and for return of filtered fluid and extravasated proteins to the blood. Given this background, the aims of this treatise are to summarize our current understanding of the factors involved in the regulation of transcapillary fluid movement, how fluid movements across the endothelial barrier and through the interstitium and lymphatic vessels influence cell function and behavior, and the pathophysiology of edema formation. Table of Contents: Fluid Movement Across the Endothelial Barrier / The Interstitium / The Lymphatic Vasculature / Pathophysiology of Edema Formation
This manual lymph drainage guide covers the anatomy, physiology, and pathophysiology of the lymphatic system, providing key background information necessary for effective treatment. Chapters are structured according to anatomic regions, focusing on the lymphatic knots and their tributary regions in the throat, armpit, trunk, and groin. Photographs illustrate the lymphatic knots and lymphatic courses, which are drawn on the human body, and provide a clear picture of the structures to be treated. Designated points are numbered to illustrate the progression of treatment in each region. Also includes coverage of complete decongestive therapy (CDT). - Explains procedures in a detailed, step-by-step format. - Features a helpful chart of lymph node groups and their tributary regions that outlines each lymph node as it pertains to a specific anatomical region. - Key information is summarized in the margins, making it easier for readers to review what they've read and focus on important topics. - Self-test questions provide an excellent means for readers to assess their comprehension and review key material in the book. These questions are also helpful in preparing for exams. - Two-color illustrations help the reader visualize and learn theoretical aspects of this therapy. - The text has been completely updated to reflect the latest techniques in lymph drainage therapy. - Coverage of individual treatment strokes and stroke sequences have been updated, with more comprehensive descriptions and detailed photos that illustrate proper hand placement, pressure, and movement. - Expanded coverage of complete decongestive therapy, including a CDT survey — consisting of the case history, examination, and palpation — that can be used to gather valuable information to formulate therapeutic goals and evaluate treatment results.
This book provides research on the components, functions and diseases of the lymphatic system. Chapter One reviews the role of lymphatic drainage of cerebrospinal fluid from the brain. In particular, the authors review the current hypotheses on the possible drainage of lymphatic fluid from the brain. Chapter Two expose the actual refinements of the surgical technique for the pedicled and free greater omentum flap, facing the treatment lymphedema. Chapter Three summarises the recent development of the molecular mechanisms of tumor lymphangiogenesis, especially the role of bone marrow-derived cells and the growth factors implicated in this process. Chapter Four reviews molecular mechanisms related to the activation of tumor lymphangiogenesis and their clinical implications.
Although lymphoscintigraphy was originally introduced into clinical routine for identification of the cause of peripheral edema, more recently it has been widely applied for radioguided biopsy of the sentinel lymph node in patients with solid cancers. The procedure is now considered crucial for adequate planning of oncologic surgery in a growing number of cancers. This atlas presents a collection of richly illustrated teaching cases that demonstrate the clinical relevance and impact of lymphoscintigraphy in different pathologic conditions. After introductory chapters on the anatomy, physiology, and pathophysiology of lymphatic circulation, the role of lymphoscintigraphy in differential diagnosis of peripheral edema and characterization of intracavitary lymph effusions is addressed. The principal focus of the book, however, is on the use of lymphoscintigraphic mapping for radioguided sentinel node biopsy in cutaneous melanoma and cancers at a range of anatomic sites. The most commonly observed lymphoscintigraphic patterns are depicted, and anatomic variants and technical pitfalls of the procedure receive careful attention. The role of tomographic multimodality imaging is also considered. The atlas will be an excellent learning tool for residents in nuclear medicine and other specialists with an interest in the field.