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This book guides researchers in performing and presenting high-quality analyses of all kinds of non-randomized studies, including analyses of observational studies, claims database analyses, assessment of registry data, survey data, pharmaco-economic data, and many more applications. The text is sufficiently detailed to provide not only general guidance, but to help the researcher through all of the standard issues that arise in such analyses. Just enough theory is included to allow the reader to understand the pros and cons of alternative approaches and when to use each method. The numerous contributors to this book illustrate, via real-world numerical examples and SAS code, appropriate implementations of alternative methods. The end result is that researchers will learn how to present high-quality and transparent analyses that will lead to fair and objective decisions from observational data. This book is part of the SAS Press program.
This book guides researchers in performing and presenting high-quality analyses of all kinds of non-randomized studies, including analyses of observational studies, claims database analyses, assessment of registry data, survey data, pharmaco-economic data, and many more applications. The text is sufficiently detailed to provide not only general guidance, but to help the researcher through all of the standard issues that arise in such analyses. Just enough theory is included to allow the reader to understand the pros and cons of alternative approaches and when to use each method. The numerous contributors to this book illustrate, via real-world numerical examples and SAS code, appropriate implementations of alternative methods. The end result is that researchers will learn how to present high-quality and transparent analyses that will lead to fair and objective decisions from observational data. This book is part of the SAS Press program.
Discover best practices for real world data research with SAS code and examples Real world health care data is common and growing in use with sources such as observational studies, patient registries, electronic medical record databases, insurance healthcare claims databases, as well as data from pragmatic trials. This data serves as the basis for the growing use of real world evidence in medical decision-making. However, the data itself is not evidence. Analytical methods must be used to turn real world data into valid and meaningful evidence. Real World Health Care Data Analysis: Causal Methods and Implementation Using SAS brings together best practices for causal comparative effectiveness analyses based on real world data in a single location and provides SAS code and examples to make the analyses relatively easy and efficient. The book focuses on analytic methods adjusted for time-independent confounding, which are useful when comparing the effect of different potential interventions on some outcome of interest when there is no randomization. These methods include: propensity score matching, stratification methods, weighting methods, regression methods, and approaches that combine and average across these methods methods for comparing two interventions as well as comparisons between three or more interventions algorithms for personalized medicine sensitivity analyses for unmeasured confounding
Discover best practices for real world data research with SAS code and examples Real world health care data is common and growing in use with sources such as observational studies, patient registries, electronic medical record databases, insurance healthcare claims databases, as well as data from pragmatic trials. This data serves as the basis for the growing use of real world evidence in medical decision-making. However, the data itself is not evidence. Analytical methods must be used to turn real world data into valid and meaningful evidence. Real World Health Care Data Analysis: Causal Methods and Implementation Using SAS brings together best practices for causal comparative effectiveness analyses based on real world data in a single location and provides SAS code and examples to make the analyses relatively easy and efficient. The book focuses on analytic methods adjusted for time-independent confounding, which are useful when comparing the effect of different potential interventions on some outcome of interest when there is no randomization. These methods include: propensity score matching, stratification methods, weighting methods, regression methods, and approaches that combine and average across these methods methods for comparing two interventions as well as comparisons between three or more interventions algorithms for personalized medicine sensitivity analyses for unmeasured confounding
Statistical analysis is ubiquitous in modern medical research. Logistic regression, generalized linear models, random effects models, and Cox's regression all have become commonplace in the medical literature. But while statistical software such as SAS make routine application of these techniques possible, users who are not primarily statisticians
Written with medical statisticians and medical researchers in mind, this intermediate-level reference explores the use of SAS for analyzing medical data. Applied Medical Statistics Using SAS covers the whole range of modern statistical methods used in the analysis of medical data, including regression, analysis of variance and covariance, longitudinal and survival data analysis, missing data, generalized additive models (GAMs), and Bayesian methods. The book focuses on performing these analyses using SAS, the software package of choice for those analysing medical data. Features Covers the planning stage of medical studies in detail; several chapters contain details of sample size estimation Illustrates methods of randomisation that might be employed for clinical trials Covers topics that have become of great importance in the 21st century, including Bayesian methods and multiple imputation Its breadth and depth, coupled with the inclusion of all the SAS code, make this book ideal for practitioners as well as for a graduate class in biostatistics or public health. Complete data sets, all the SAS code, and complete outputs can be found on an associated website: http://support.sas.com/amsus
Statistical analysis is ubiquitous in modern medical research. Logistic regression, generalized linear models, random effects models, and Cox's regression all have become commonplace in the medical literature. But while statistical software such as SAS make routine application of these techniques possible, users who are not primarily statisticians must take care to correctly implement the various procedures and correctly interpret the output. Statistical Analysis of Medical Data Using SAS demonstrates how to use SAS to analyze medical data. Each chapter addresses a particular analysis method. The authors briefly describe each procedure, but focus on its SAS implementation and properly interpreting the output. The carefully designed presentation relegates the theoretical details to "Displays," so that the code and results can be explored without interruption. All of the code and data sets used in the book are available for download from either the SAS Web site or www.crcpress.com. Der and Everitt, authors of the best-selling Handbook of Statistical Analyses Using SAS, bring all of their considerable talent and experience to bear in this book. Step-by-step instructions, lucid explanations and clear examples combine to form an outstanding, self-contained guide--suitable for medical researchers and statisticians alike--to using SAS to analyze medical data.
Provides a concise yet complete foundational knowledge of the business of healthcare. Administrative Healthcare Data: A Guide to Its Origin, Content, and Application Using SAS explains the source and content of administrative healthcare data, which is the product of financial reimbursement for healthcare services. The book integrates the business knowledge of healthcare data with practical and pertinent case studies as shown in SAS Enterprise Guide. The book's blend of SAS programming and industry knowledge is unique. It illustrates concepts of administrative healthcare data with actual healthcare case studies. All applications are created with SAS Enterprise Guide or Base SAS and can be taken straight from the book and put to use immediately. Central topics addressed include key players in the healthcare industry and the roles they play; claim submission mechanisms used by different providers; medical claim content, both pre- and post-adjudication. Written for healthcare analysts regardless of their level of proficiency with SAS Enterprise Guide, SAS programming, or healthcare industry knowledge, Administrative Healthcare Data is a must-read for analysts new to the industry and a great review for experienced healthcare analysts. This book is part of the SAS Press program.
The aim of this textbook (previously titled SAS for Data Analytics) is to teach the use of SAS for statistical analysis of data for advanced undergraduate and graduate students in statistics, data science, and disciplines involving analyzing data. The book begins with an introduction beyond the basics of SAS, illustrated with non-trivial, real-world, worked examples. It proceeds to SAS programming and applications, SAS graphics, statistical analysis of regression models, analysis of variance models, analysis of variance with random and mixed effects models, and then takes the discussion beyond regression and analysis of variance to conclude. Pedagogically, the authors introduce theory and methodological basis topic by topic, present a problem as an application, followed by a SAS analysis of the data provided and a discussion of results. The text focuses on applied statistical problems and methods. Key features include: end of chapter exercises, downloadable SAS code and data sets, and advanced material suitable for a second course in applied statistics with every method explained using SAS analysis to illustrate a real-world problem. New to this edition: • Covers SAS v9.2 and incorporates new commands • Uses SAS ODS (output delivery system) for reproduction of tables and graphics output • Presents new commands needed to produce ODS output • All chapters rewritten for clarity • New and updated examples throughout • All SAS outputs are new and updated, including graphics • More exercises and problems • Completely new chapter on analysis of nonlinear and generalized linear models • Completely new appendix Mervyn G. Marasinghe, PhD, is Associate Professor Emeritus of Statistics at Iowa State University, where he has taught courses in statistical methods and statistical computing. Kenneth J. Koehler, PhD, is University Professor of Statistics at Iowa State University, where he teaches courses in statistical methodology at both graduate and undergraduate levels and primarily uses SAS to supplement his teaching.
This book is intended for use as the textbook in a second course in applied statistics that covers topics in multiple regression and analysis of variance at an intermediate level. Generally, students enrolled in such courses are p- marily graduate majors or advanced undergraduate students from a variety of disciplines. These students typically have taken an introductory-level s- tistical methods course that requires the use a software system such as SAS for performing statistical analysis. Thus students are expected to have an - derstanding of basic concepts of statistical inference such as estimation and hypothesis testing. Understandably, adequate time is not available in a ?rst course in stat- tical methods to cover the use of a software system adequately in the amount of time available for instruction. The aim of this book is to teach how to use the SAS system for data analysis. The SAS language is introduced at a level of sophistication not found in most introductory SAS books. Important features such as SAS data step programming, pointers, and line-hold spe- ?ers are described in detail. The powerful graphics support available in SAS is emphasized throughout, and many worked SAS program examples contain graphic components.