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This report considers the biological and behavioral mechanisms that may underlie the pathogenicity of tobacco smoke. Many Surgeon General's reports have considered research findings on mechanisms in assessing the biological plausibility of associations observed in epidemiologic studies. Mechanisms of disease are important because they may provide plausibility, which is one of the guideline criteria for assessing evidence on causation. This report specifically reviews the evidence on the potential mechanisms by which smoking causes diseases and considers whether a mechanism is likely to be operative in the production of human disease by tobacco smoke. This evidence is relevant to understanding how smoking causes disease, to identifying those who may be particularly susceptible, and to assessing the potential risks of tobacco products.
As a baby, Simon Gray discovered that he could move his pram while still nestling inside it. 'It was a complete mystery to the adult intelligences, how had he done it, if it was he who had done it, but if not he, who then and why? So the next afternoon they (Mummy and Nanny) planted the pram in the usual spot, and stood over it, watching - the baby lay there smiling or snivelling up at them, until it struck them that they should try observing the baby when unobserved by the baby, and they withdrew behind bushes and trees etc.; and thus witnessed the swaying of the pram, then the juddering of the pram, then its slow, unsteady progress along the path, the movement accompanied by a low humming and keening sound from within that reminded them more of a dog than a human ... "jouncing" was the word they used for it. I was a jouncer therefore.' In the second book of his chronicles of triumph and disaster which started with The Smoking Diaries, Gray intertwined scenes from his adult and his childish self to produce a brilliant and moving counterpoint of life's unsteady progress.
NAMED A BEST BOOK OF THE YEAR BY THE ECONOMIST By turns philosophical and darkly comic, an ex-smoker’s meditation on the nature and consequences of his nearly lifelong addiction. Written with the passion of an obsessive, Nicotine addresses a lifelong addiction, from the thrill of the first drag to the perennial last last cigarette. Reflecting on his experiences as a smoker from a young age, Gregor Hens investigates the irreversible effects of nicotine on thought and patterns of behavior. He extends the conversation with other smokers to meditations on Mark Twain and Italo Svevo, the nature of habit, and the validity of hypnosis. With comic insight and meticulous precision, Hens deconstructs every facet of dependency, offering a brilliant analysis of the psychopathology of addiction. This is a book about the physical, emotional, and psychological power of nicotine as not only an addictive drug, but also a gateway to memory, a long trail of streetlights in the rearview mirror of a smoker’s life. Cigarettes are sometimes a solace, sometimes a weakness, but always a witness and companion. This is a meditation, an ode, and a eulogy, one that will be passed hand-to-hand between close friends.
Quarterly accession lists; beginning with Apr. 1893, the bulletin is limited to "subject lists, special bibliographies, and reprints or facsimiles of original documents, prints and manuscripts in the Library," the accessions being recorded in a separate classified list, Jan.-Apr. 1893, a weekly bulletin Apr. 1893-Apr. 1894, as well as a classified list of later accessions in the last number published of the bulletin itself (Jan. 1896)