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In this "must-read" guide (Lonnie Ali), four leading doctors and advocates offer a bold action plan to prevent, care for, and treat Parkinson's disease-one of the great health challenges of our time. Brain diseases are now the world's leading source of disability. The fastest growing of these is Parkinson's: the number of impacted patients has doubled to more than six million over the last twenty-five years and is projected to double again by 2040. Harmful pesticides that increase the risk of Parkinson's continue to proliferate, many people remain undiagnosed and untreated, research funding stagnates, and the most effective treatment is now a half century old. In Ending Parkinson's Disease, four top experts provide a plan to help prevent Parkinson's, improve care and treatment, and end the silence associated with this devastating disease.
The brain is the most complex organ in our body. Indeed, it is perhaps the most complex structure we have ever encountered in nature. Both structurally and functionally, there are many peculiarities that differentiate the brain from all other organs. The brain is our connection to the world around us and by governing nervous system and higher function, any disturbance induces severe neurological and psychiatric disorders that can have a devastating effect on quality of life. Our understanding of the physiology and biochemistry of the brain has improved dramatically in the last two decades. In particular, the critical role of cations, including magnesium, has become evident, even if incompletely understood at a mechanistic level. The exact role and regulation of magnesium, in particular, remains elusive, largely because intracellular levels are so difficult to routinely quantify. Nonetheless, the importance of magnesium to normal central nervous system activity is self-evident given the complicated homeostatic mechanisms that maintain the concentration of this cation within strict limits essential for normal physiology and metabolism. There is also considerable accumulating evidence to suggest alterations to some brain functions in both normal and pathological conditions may be linked to alterations in local magnesium concentration. This book, containing chapters written by some of the foremost experts in the field of magnesium research, brings together the latest in experimental and clinical magnesium research as it relates to the central nervous system. It offers a complete and updated view of magnesiums involvement in central nervous system function and in so doing, brings together two main pillars of contemporary neuroscience research, namely providing an explanation for the molecular mechanisms involved in brain function, and emphasizing the connections between the molecular changes and behavior. It is the untiring efforts of those magnesium researchers who have dedicated their lives to unraveling the mysteries of magnesiums role in biological systems that has inspired the collation of this volume of work.
After graduating from Tripoli, Libya in 1990, Dr Benamer came to the United Kingdom in 1991 to further his training in medicine. He obtained the MRCP in 1994 and trained in neurology in Glasgow. He obtained a PhD and CCST in 2000 and was appointed a consultant neurologist in Wolverhampton and Birmingham the same year. He has been the lead neurologist in New Cross Hospital in Wolverhampton since 2006. Dr Benamer is a general neurologist with special interest in movement disorders. Dr Benamer is honorary clinical senior lecturer in Birmingham University and has an interest in medical education, in which he obtained a postgraduate certificate from Keele University in 2007. He has published more than 35 papers and two books. He is currently a senior editor of the Libyan Journal of Medicine. He was also an examiner of the MRCP Diploma from 2005 to 2009. Dr Benamer's publications relevant to the subject of the book: 1. Benamer HT. 2007. Neurological disorders in Libya: an overview. Neuroepidemiology 29:143-9 2. Benamer HT. 2008. The ancestry of LRRK2 Gly2019Ser parkinsonism. Lancet neurology 7:769-70; author reply 70-1 3. Benamer HT, de Silva R, Siddiqui KA, Grosset DG. 2008. Parkinson's disease in Arabs: a systematic review. Movement disorders: official journal of the Movement Disorder Society 23:1205-10 4. Benamer HT, Ahmed ES, Al-Din AS, Grosset DG. 2009. Frequency and clinical patterns of multiple sclerosis in Arab countries: a systematic review. Journal of the neurological sciences 278:1-4 5. Benamer HT, Grosset D. 2009. Stroke in Arab countries: a systematic literature review. Journal of the neurological sciences 284:18-23 6. Benamer HT, Grosset DG. 2009. A systematic review of the epidemiology of epilepsy in Arab countries. Epilepsia 50:2301-4 7. Benamer HT, Shakir RA. 2009. The neurology map of the Arab world. Journal of the neurological sciences 285:10-2 8. Benamer HT. 2010. Neurology expertise and postgraduate training programmes in the Arab world: a survey. European neurology 64:313-8 9. Benamer HT, de Silva R. 2010. LRRK2 G2019S in the North African population: a review. European neurology 63:321-5 10. Benamer HT, Deleu D, Grosset D. 2010. Epidemiology of headache in Arab countries. The journal of headache and pain 11:1-3 11. Benamer HT. 2011. More epidemiological studies of neurological disorders are needed in the Arab countries. Neuroepidemiology 36:70.
Covering a wide range of diverse age-related disorders, Degenerative Disorders of the Brain addresses disabilities that occur or have their roots in the later stages of life. The book brings together an internationally recognised group of contributors to discuss frontostriatal, fronto-cerebellar and other major brain systems and structures which control and direct normal behaviour, and which can fail during the aging process, as well as addressing behavioural, clinical, pathophysiological and technical aspects. Discussing the latest clinical and behavioural findings of disorders which are largely, though not necessarily entirely, age related, including Alzheimer's disease and other dementias, Parkinson's disease and related disorders, and Huntington's disease, the book covers information vital to the understanding, diagnosis, and management of degenerative disorders of the brain. It also considers the role of epigenetics, neural plasticity, and environmental enrichment in neurodegenerative disorders alongside the role of ground-breaking intervention methods, including transcranial magnetic stimulation and deep brain stimulation. Degenerative Disorders of the Brain will be of great interest to, and use for, clinicians, researchers, students, lecturers, and affected individuals and their relatives.
This comprehensive reference provides a detailed overview of current concepts regarding the cause of Parkinson's disease-emphasizing the issues involved in the design, implementation, and analysis of epidemiological studies of parkinsonism.
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