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For we must consider that we shall be as a city upon a hill," John Winthrop warned his fellow Puritans at New England's founding in 1630. More than three centuries later, Ronald Reagan remade that passage into a timeless celebration of American promise. How were Winthrop's long-forgotten words reinvented as a central statement of American identity and exceptionalism? In As a City on a Hill, leading American intellectual historian Daniel Rodgers tells the surprising story of one of the most celebrated documents in the canon of the American idea. In doing so, he brings to life the ideas Winthrop's text carried in its own time and the sharply different yearnings that have been attributed to it since. As a City on a Hill shows how much more malleable, more saturated with vulnerability, and less distinctly American Winthrop's "Model of Christian Charity" was than the document that twentieth-century Americans invented. Across almost four centuries, Rodgers traces striking shifts in the meaning of Winthrop's words--from Winthrop's own anxious reckoning with the scrutiny of the world, through Abraham Lincoln's haunting reference to this "almost chosen people," to the "city on a hill" that African Americans hoped to construct in Liberia, to the era of Donald Trump. As a City on a Hill reveals the circuitous, unexpected ways Winthrop's words came to lodge in American consciousness. At the same time, the book offers a probing reflection on how nationalism encourages the invention of "timeless" texts to straighten out the crooked realities of the past.
A comprehensive manual that provides the shorthand outlines for a host of words, including personal and geographical names
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An aid to solving crosswords. It contains over 100,000 potential solutions, including plurals, comparative and superlative adjectives, and inflections of verbs. The list extends to first names, place names and technical terms, euphemisms and compound expressions, as well as abbreviations.
Alphaherpesviruses are a fascinating group of DNA viruses that includes important human pathogens such as herpes simplex virus type 1 (HSV-1), HSV-2, and varicella-zoster virus (VZV): the causative agents of cold sores, genital ulcerous disease, and chickenpox/shingles, respectively. A key attribute of these viruses is their ability to establish lifelong latent infection in the peripheral nervous system of the host. Such persistence requires subversion of the host's immune system and intrinsic antiviral defense mechanisms. Understanding the mechanisms of the immune evasion and what triggers viral reactivation is a major challenge for today's researchers. This has prompted enormous research efforts into understanding the molecular and cellular biology of these viruses. This up-to-date and comprehensive volume aims to distill the most important research in this area providing a timely overview of the field. Topics covered include: transcriptional regulation, DNA replication, translational control, virus entry and capsid assembly, the role of microRNAs in infection and oncolytic vectors for cancer therapy. In addition there is coverage of virus-host interactions, including apoptosis, subversion of host protein quality control and DNA damage response pathways, autophagy, establishment and reactivation from latency, interferon responses, immunity and vaccine development. Essential reading for everyone working with alphaherpesviruses and of interest to all virologists working on latent infections.
Ally knows her super-efficient big sis Linn finds their chaotic family a bit ... exasperating. But when Linn falls for Q, the tearaway lead singer in a local band, all her sensible ways go out of the window. Everyone else can see that Q's a creep, but does Ally have the courage to burst Linn's heart-shaped bubble?