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A unique case-based molecular approach to understanding pathology Pathology: A Modern Case Study is a concise, focused text that emphasizes the molecular and cellular biology essential to understanding the concepts of disease causation. The book includes numerous case studies designed to highlight the role of the pathologist in the team that provides patient care. Pathology: A Modern Case Study examines the role of anatomic, clinical, and molecular pathologists in dedicated chapters and in descriptions of the pathology of specific organ systems. Features Coverage of pathology focuses on modern approaches to common and important diseases Each chapter delivers the most up-to-date advances in pathology Learning aids include chapter summaries and overviews, bolded terms, and a glossary Common clinically relevant disease are highlighted Disease discussion is based on organ compartment and etiology Coverage includes: Disease and the Genome: Genetic, Developmental and Neoplastic Disease Cell Injury, Death and Aging and the Body's Response Environmental Injury Clinical Practice: Anatomic Pathology Clinical Practice: Molecular Pathology Clinical Practice: Molecular Pathology Organ-specific pathology covering all major body systems Molecular pathology Essential for undergraduate medical students and clinicians who wish to expand their knowledge pathology, Pathology: A Modern Case Study delivers valuable coverage that is directly related to a patient’s condition and the clinical practice of pathology.
A Video Atlas of Neuromuscular Disorders is the essential reference on adult neuromuscular disorders and their diagnosis and treatment. Perfect for preparing for the neurology and neuromuscular boards, this book and accompanying videos have become an invaluable resource for neurology and neuromuscular training programs, while catering to the too-busy and often-overwhelmed modern doctor with its straightforward structure and language.
The atlas contains a comprehensive outline of neuromuscular diseases, written by experienced American and European authors. It discusses all aspects of neuromuscular disorders including the cranial nerves, spinal nerves, motor neurone disease, the nerve plexus, and many others. Each chapter is uniformly structured into anatomy, symptoms, signs, pathogenetic possibilities, diagnosis and differential diagnosis, therapy and prognosis. Additionally, the diagnostic tools and investigations used in neuromuscular disease are explained and a practical guide is given on how to advance from symptoms to syndromes. For each disease the therapeutic options are described. It contains large number of clinical and histologic pictures and artists drawings.
During the last 20 years the development of enzyme histochemical techniques has contributed greatly to knowledge of muscle pathology. However, these and other new methods, such as electron microscopy and immunocytochemistry, have only relatively recently become gener ally available for routine use in histopathology. Muscle biopsy is a long-established technique in clinical practice, having been introduced by Duchenne in 1868 (Arch. Gen. Med. , 11, 5-179). However, the needle method used by Duchenne was not generally adopted, although Shank and Hoagland described a similar technique in 1943 (Science, 98, 592). During this time muscle biopsies required a surgical procedure and this was a considerable disincentive to their use. It was not until Bergstrom (1962; Scand. J. Clin. Lab. Invest. , 14, Suppl. 68) and Edwards (1971; Lancet, ii, 593--6) developed a simple biopsy needle suitable for muscle work in connection with exercise physiology that the advantages of needle muscle biopsies came to be appreciated. Since then, muscle biopsies have become a relatively minor procedure. This has led to the increasing use of muscle biopsy in clinical practice, both for diagnosis and for assessing progress in repeated biopsies during the course of a disorder and its treatment. The full range of enzyme histochemical and ultrastructural histological techniques can be applied to these small biopsies and many of the older histological staining methods can also be used. This book is intended to serve as a practical guide in muscle pathology, particularly for histopathologists, and for those in training.
Neuromuscular Ultrasound demonstrates the use of ultrasound as an alternative to electrodiagnosis in the evaluation of neuromuscular disorders through detailed descriptions and clear illustrations. Drs. Francis Walker and Michael S. Cartwright discuss techniques for visualizing muscles and nerves without painful testing for better patient compliance and more efficient diagnosis. Color illustrations, pearls for the clinician, and ultrasound videos online at www.expertconsult.com, ensure that you'll be able to apply this technology effectively in your practice. - Access the fully searchable text online at www.expertconsult.com, along with ultrasound videos that demonstrate ultrasound evaluation in real time. - Diagnose and manage your patients more quickly and easily by visualizing muscles and nerves without painful testing. - Master the nuances of using ultrasound through the visual instruction of clear images and illustrations. - Minimize patient discomfort while maximizing optimal patient evaluation with a practical focus that covers using ultrasound as a screening tool, provides clinical pearls, and includes comparisons to electrodiagnosis. - Apply the full range of ultrasound applications, including interventional uses (such as ultrasound-guided botulinum toxin and steroid injections), ultrasound of polyneuropathies (often found in diabetics), and more.
This book focuses on the anatomy of the peripheral nervous system. Using the latest 3D-computer graphic modeling techniques, the author developed the innovative NEURO 3D LOCATORTM concept, which provides 3D in-vivo ultrasound images of peripheral nerve architectures, allowing readers to develop a mental real-time 3D GPS of the peripheral nervous system. This new edition is an extended version of the “Student edition” dedicated to Experts and is divided into three main parts: The first part describes fundamental concepts, from immunohistochemistry to limb innervation, and includes a detailed evaluation of the morphofunctional anatomy of the peripheral nerves. It also presents relevant data on neuromuscular transmission, from both classic and recent literature, to enable readers to gain an understanding the physiology and pathology of peripheral nerves as well as the prospects of repair. The second section addresses the upper limb, the brachial plexus and related peripheral nerves, while the third section focuses on the lower limb, the lumbosacral plexus and related peripheral nerves. By providing MRI sections related to the drawings and the descriptions of main nerve injuries, it facilitates radiological interpretation and clinical learning. The book also features detailed descriptions of surgical approaches and the ultrasound anatomy of the limbs, and includes supplementary material on applications to peripheral nerve stimulation, surgical procedures and interventional pain medicine techniques. Presenting high-quality 3D videos showing the progression of the ultrasound probe in real-time, synchronized with live ultrasound views and enhanced with anatomical computerized graphic layers, as well as over 500 outstanding full-color 2D and 3D illustrations, and access to than 100 practical videos, this unique book is a valuable resource for anesthesiologists, radiologists, orthopedic surgeons, neurosurgeons, neuromodulators, physiatrists, pain physicians and rheumatologists. It will also appeal to the medical community in general.
Nine years have elapsed since the second edition of this book was published. In this time the principal advances in neuromuscular diseases have been in the application of molecular genetics to understanding the aetiology and pathogenesis of this group of disorders. As a result many previously unrecognised disorders have been charac terised. Some clinical syndromes, such as the limb girdle dystrophies, have become better defined. In many such instances the new genetic information has led to major advances in knowledge of the biology of cell structures, for example, the membrane structural and channel proteins. The clinical syndromes themselves, and their patho logical and electrophysiological characteristics, however, remain as important as ever, since they constitute the clinical problem itself and, indeed, the database from which all other concepts emerge. Knowledge of the pathogenesis, genetics, and molecular biology of neuromuscular disorders is essential both in developing and applying new therapies and preventive measures, and in formulating genetic and prognostic advice. However, this informa tion does not necessarily always define clinically useful syndromes. Myotonia, for example, is an electrophysiological finding in some syndromes in which it is un detectable by clinical examination, although the phenomenon itself was originally defined as a clinical entity. The limb girdle muscular dystrophy syndromes can be defined by severity, distribution of weakness, age of onset, sex distribution and other characteristics and many of these can be better understood by study of the under lying defect in cell structural proteins.
With the advent of enzyme histochemistry, which this field and simplistic theories will be expanded or revealed hitherto unseen pathological differences discarded. between muscle disorders, muscle biopsy assumed Diseased muscle cells, as any other cell type, show an important diagnostic role. The investigation is easily only limited morphological changes. However bizarre, performed and is being undertaken with increasing very few of these changes, if any, are pathognomonic of frequency. Nevertheless there is still a tendency to a single disease. The exact significance of microscopic regard its interpretation as highly specialized and out findings is to a large extent determined by their clinical side the province of the general histopathologist. In this context. Thus, although this is an atlas, it is definitely atlas I have tried to lift the veil of neuropathological not designed to promote 'spot' histological diagnoses. I mystique and to describe and illustrate the basic have aimed to provide a guide to pathological reactions reactions of muscle cells. of muscle which will be useful to the practising histo Interpretation of the biopsy depends not only upon pathologist and all students of neuro-muscular disease. recognition of morphological abnormalities, but upon I hope that recognition of the lack of specificity of understanding why they occur. Throughout the atlas I individual morphological features will encourage the have attempted to correlate morphological changes . close clinico-pathological correlation which is essential with pathogenetic mechanisms.
This atlas presents a comprehensive outline of neuromuscular diseases, written by respected American and European authors. It discusses all aspects of neuromuscular disorders including cranial and spinal nerves, motor neuron diseases, nerve plexus, peripheral nerves, mono- and polyneuropathies, entrapment syndromes, neuromuscular junctions, and muscle disease. Each chapter is structured into the following sections: anatomy, symptoms, signs, pathogenesis, diagnosis and differential diagnosis, therapy and prognosis. The diagnostic tools in neuromuscular disease are explained and practical guidelines are offered on how to advance from symptoms to syndromes. The therapeutic options for each disease are also described. In this new edition, the structure of the chapters has been reorganized and chapters on principles of peripheral nerves, nerve pain, nerve surgery and rehabilitation have been added. The current trend of increased use of imaging techniques such as US and MRI in the diagnosis and follow-up of neuromuscular disorders is also reflected.
The term arthrogryposis describes a range of congenital contractures that lead to childhood deformities. It encompasses a number of syndromes and sporadic deformities that are rare individually but collectively are not uncommon. Yet, the existing medical literature on arthrogryposis is sparse and often confusing. The aim of this book is to provide individuals affected with arthrogryposis, their families, and health care professionals with a helpful guide to better understand the condition and its therapy. With this goal in mind, the editors have taken great care to ensure that the presentation of complex clinical information is at once scientifically accurate, patient oriented, and accessible to readers without a medical background. The book is authored primarily by members of the medical staff of the Arthrogryposis Clinic at Children's Hospital and Medical Center in Seattle, Washington, one of the leading teams in the management of the condition, and will be an invaluable resource for both health care professionals and families of affected individuals.