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This book documents and presents new developments in the study of amebiasis, one of the neglected tropical diseases. Nearly 50 million people worldwide are infected with the pathogen Entamoeba histolytica, causing large-scale morbidity and mortality particularly in developing countries. This book will help clinicians for better diagnosis and management of the disease, researchers for initiating research projects on some of the poorly understood aspects of the disease and the pathogen, and students for updating their knowledge. The subjects covered range from genomics and molecular and cell biology to drug resistance and new drug development, highlighting major advances in recent years in our understanding due to rapid progress in genomic and other biomedical technologies, such as visualization of molecular processes. Most of the chapters provide recent information based on latest publications. A few chapters describe some of the critical methodological issues that will be helpful for students and researchers interested in getting into the field. The contributing authors include almost all the active researchers and clinicians from around the world. This book will be a useful primary material and a valuable source of information for anyone interested in understanding amebiasis, its diagnosis, and treatment. It will also be useful to those who are interested in learning about the biology of early branching eukaryotes and protist pathogens.
Amebiasis, a parasitic disease transmitted by the unicellular protozoan parasite Entamoeba histolytica, is the cause of at least 100,000 deaths each year. The disease is mostly prevalent in developing countries and is one of the three common causes of death from parasitic diseases. The parasite has two stages in its life cycle in the host: the infective cyst and the invasive trophozoite. In the large intestine, the parasite feeds on bacteria and on cellular debris. No vaccine against amebiasis currently exists. Although metronidazole is the drug of choice for treating amebiasis, adverse effects in patients and potential resistance to metronidazole in other protozoa exist. About nine out of 10 people who are infected with E. histolytica are asymptomatic and in those individuals who develop symptoms, bloody diarrhea (amebic colitis) and liver abscess are the most common symptoms. One possible explanation for this observation is the difference in the gut microbiota between individuals that may significantly influence the host’s immune response in amebiasis and E. histolytica's virulence. Amebiasis is characterized by acute inflammation of the intestine with release of pro-inflammatory cytokines, reactive oxygen species and reactive nitrogen species from activated cells of the host's immune system. In recent years, significant advances on the cell biology of Entamoeba infection have been achieved through the development of new genetic tools to manipulate gene expression in the parasite and through the application of Omics tools. In this Research Topic, we welcome high quality original research articles, as well as review, opinion or method articles, on amebiasis including but not limited to the regulation of gene expression, cell biology and signaling, adaptation and resistance to environmental stresses, metabolism, pathogenesis and immunity, pathogenesis and microbiome, drug discovery and drug resistance.
This book provides a comprehensive overview of diagnostic imaging in infectious diseases. It starts with a general review of infection diseases, including their classification, characteristics and epidemiology. In separate chapters, the authors then introduce the radionuclide imaging of 50 kinds of infectious diseases. Volume 1 covers 21 viral infections. Volume 2 has 29 chapters discussing 24 bacterial infections and 5 parasitic infections. Each disease is clearly illustrated using cases combined with high-quality computed tomography (CT) and magnetic resonance imaging (MRI). The book provides a valuable reference source for radiologists and doctors working in the area of infectious diseases.
Liver Pathophysiology: Therapies and Antioxidants is a complete volume on morphology, physiology, biochemistry, molecular biology and treatment of liver diseases. It uses an integral approach towards the role of free radicals in the pathogenesis of hepatic injury, and how their deleterious effects may be abrogated by the use of antioxidants. Written by the most prominent authors in the field, this book will be of use to basic and clinical scientists and clinicians working in the biological sciences, especially those dedicated to the study and treatment of liver pathologies. - Presents the most recent advances in hepatology, with a special focus on the role of oxidative stress in liver injury. - Provides in vivo and in vitro models to study human liver pathology. - Explains the beneficial effects of antioxidants on liver diseases. - Contains the most recent and modern treatments of hepatic pathologies, including, but not limited to, stem cells repopulation, gene therapy and liver transplantation.
This book examines the two major parasite groups that are transmitted via water or foods: the single-celled protozoa, and the helminths: cestodes (tapeworms), nematodes (round worms), and trematodes (flukes). Each chapter covers the biology, mechanisms of pathogenesis, epidemiology, treatment, and inactivation of these parasites. This important new text offers a better understanding of the biology and control of parasitic infections necessary to reduce or eliminate future outbreaks in the U.S. and elsewhere.
This very well-received book, now in its second edition, equips the radiologist with the information needed in order to diagnose internal medicine disorders and their complications from the radiological perspective. It offers an easy-to-consult tool that documents the most common and most important radiological signs of a wide range of diseases, across diverse specialties, with the aid of an excellent gallery of images and illustrations. Compared with the first edition, numerous additions and updates have been made, with coverage of additional disorders and inclusion of many new images. Entirely new chapters focus on occupational medicine and toxicology imaging, chiropractic medicine, and energy and quantum medicine. Internal Medicine – An Illustrated Radiological Guide puts the radiologist in the internal medicine physician’s shoes. It teaches radiologists how to think in terms of disease progression and complications, explains where to look for and to image these complications, and identifies the best modalities for reaching a diagnosis. It will also benefit internal medicine physicians by clarifying the help that radiology can offer them and assisting in the choice of investigation for diagnostic confirmation.
The Pocket Book is for use by doctors nurses and other health workers who are responsible for the care of young children at the first level referral hospitals. This second edition is based on evidence from several WHO updated and published clinical guidelines. It is for use in both inpatient and outpatient care in small hospitals with basic laboratory facilities and essential medicines. In some settings these guidelines can be used in any facilities where sick children are admitted for inpatient care. The Pocket Book is one of a series of documents and tools that support the Integrated Managem.
A collection of eight teaching units conveying essential information about the pathophysiology clinical features diagnosis epidemiology treatment and prevention of diarrhoea in children. Addressed to medical students undergoing clinical training in paediatrics the manual aims to equip students with all the knowledge needed to assess patients plan treatment and prevent deaths through proper case management. Information which is specific to conditions in developing countries ranges from an explanation of the clinical features seen in different forms of dehydration through advice on how to communicate with mothers to a discussion of the role of feeding in the management of diarrhoea. Recommended lines of action draw their authority from published research and extensive WHO experience in programmes for the treatment and prevention of diarrhoea. The first two teaching units provide fundamental information about the epidemiology clinical types of diarrhoea causative agents modes of transmission pathophysiology and implications for treatment. Subsequent units explain how the clinical assessment of patients should be performed and interpreted discuss ways of teaching mothers to treat diarrhoea at home describe clinical measures for the treatment of dehydrated patients and discuss the special procedures to be followed during the treatment of dysentery persistent diarrhoea and diarrhoea associated with other illnesses. The remaining units cover the nutritional management of diarrhoea in children including those suffering from severe malnutrition and explain how physicians can promote prevention particularly through the education of mothers and other family members. Each unit concludes with a list of exercises. Further practical information is presented in a series of annexes which include illustrated step-by-step instructions for intravenous rehydration and nasogastric rehydration.
“Water and Health” strengthens the dynamic relationship between human health and water. The book has the potential to ignite our minds about several water-related diseases due to biological and chemical contamination, and to their high-end solutions. The contents are original, comprehensive and highly informative, and gradually take the reader around the component most important to his or her quality life, and not just existence. The book is set in social, scientific and economic dimensions, and is a must read for all those who cherish and celebrate human life and dignity.