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Alginates in Drug Delivery explores the vital precepts, basic and fundamental aspects of alginates in pharmaceutical sciences, biopharmacology, and in the biotechnology industry. The use of natural polymers in healthcare applications over synthetic polymers is becoming more prevalent due to natural polymers' biocompatibility, biodegradability, economic extraction and ready availability. To fully utilize and harness the potential of alginates, this book presents a thorough understanding of the synthesis, purification, and characterization of alginates and their derivative. This book collects, in a single volume, all relevant information on alginates in health care, including recent advances in the field. This is a highly useful resource for pharmaceutical scientists, health care professionals and regulatory scientists actively involved in the pharmaceutical product and process development of natural polymer containing drug delivery, as well as postgraduate students and postdoctoral research fellows in pharmaceutical sciences. - Provides a single source on the complete alginate chemistry, collection, chemical modifications, characterization and applications in healthcare fields - Includes high quality illustrations, along with practical examples and research case studies - Contains contributions by global leaders and experts from academia, industry and regulatory agencies who are pioneers in the application of natural polysaccharides in diverse pharmaceutical fields
Natural Polysaccharides in Drug Delivery and Biomedical Applications provides a fundamental overview of natural polysaccharides, their sources, extraction methodologies, and characterizations. It covers specific natural polysaccharides and their effective application in drug delivery and biomedical use. Additionally, chapters in the book discuss key topics including the sources and extraction methodologies of natural polysaccharides, their role in tissue engineering applications, polysaccharide-based nanoparticles in biomedical applications, and their role in the delivery of anticancer drugs. Written by industry leaders and edited by experts, this book emphasizes recent advances made in the field.Natural Polysaccharides in Drug Delivery and Biomedical Applications provides academics, researchers, and pharmaceutical health care professionals with a comprehensive book on polysaccharides in pharmaceutical delivery process. - Provides fundamental concepts of natural polysaccharides as it applies to the pharmaceutical, biomedical, and biotechnology industries - Includes contributions from global leaders and experts from academia, industry, and regulatory agencies in the application of natural polysaccharides in pharmaceutical products and biomedical utilization - Offers practical examples, illustrations, chemical structures, and research case studies to help explain natural polysaccharides concepts in drug delivery and biomedical applications
The extracellular matrix (ECM) is an acellular three-dimensional network composed of proteins, glycoproteins, proteoglycans and exopolysaccharides. It primarily serves as a structural component in the tissues and organs of plants and animals, or forms biofilms in which bacterial cells are embedded. ECMs are highly dynamic structures that undergo continuous remodeling, and disruptions are frequently the result of pathological processes associated with severe diseases such as arteriosclerosis, neurodegenerative illness or cancer. In turn, bacterial biofilms are a source of concern for human health, as they are associated with resistance to antibiotics. Although exopolysaccharides are crucial for ECM formation and function, they have received considerably little attention to date. The respective chapters of this book comprehensively address such issues, and provide reviews on the structural, biochemical, molecular and biophysical properties of exopolysaccharides. These components are abundantly produced by virtually all taxa including bacteria, algae, plants, fungi, invertebrates and vertebrates. They include long unbranched homopolymers (cellulose, chitin/chitosan), linear copolymers (alginate, agarose), peptoglycans such as murein, heteropolymers like a variety of glycosaminoglycans (hyaluronan, dermatan, keratin, heparin, Pel), and branched heteropolymers such as pectin and hemicellulose. A separate chapter is dedicated to modern industrial and biomedical applications of exopolysaccharides and polysaccharide-based biocomposites. Their unique chemical, physical and mechanical properties have attracted considerable interest, inspired basic and applied research, and have already been harnessed to form structural biocomposite hybrids for tailor-made applications in regenerative medicine, bioengineering and biosensor design. Given its scope, this book provides a substantial source of basic and applied information for a wide range of scientists, as well as valuable textbook for graduate and advanced undergraduate students.
This book provides the whole spectrum of polysaccharides from basic concepts to commercial market applications. Chapters cover various types of sources, classification, properties, characterization, processing, rheology and fabrication of polysaccharide-based materials and their composites and gels. The applications of polysaccharides include in cosmetics, food science, drug delivery, biomedicine, biofuel production, marine, packaging, chromatography and environmental remediation. It also reviews the fabrication of inorganic and carbon nanomaterials from polysaccharides. The book incorporates industrial applications and will fill the gap between the exploration works in the laboratory and viable applications in related ventures.
This important and unique book comprises 12 chapters divided into three parts examining the fundamental aspects, bioadhesive formulations, and drug delivery applications. Understanding the phenomenon of bioadhesion i.e. its theories or mechanism(s) are of critical importance in developing optimum bioadhesive polymers (used in bioadhesives). Such bioadhesive polymers are the key for exhibiting the process of bioadhesion, controlled/sustained release of drugs, and drug targeting. The use of bioadhesives restricts the delivery system to the site of interest and thus offers a useful and efficient technique for targeting a drug to the desired location for a prolonged duration. This book addresses the various relevant aspects of bioadhesives in drug delivery in an easily accessible and unified manner. The book containing 12 chapters written by eminent researchers from many parts of the globe is divided into three parts: Part 1: Fundamental Aspects; Part 2: Bioadhesive Formulations; Part 3: Drug Delivery Applications. The topics covered include: Theories and mechanisms of bioadhesion; bioadhesive polymers for drug delivery applications; methods for characterization of bioadhesiveness of drug delivery systems; bioadhesive films and drug delivery applications; bioadhesive nanoparticles; bioadhesive hydrogels and applications; ocular biodhesive drug delivery systems; buccal bioadhesive drug delivery systems; gastrointestinal bioadhesive drug delivery systems; nasal bioadhesive drug delivery systems; vaginal drug delivery systems; pulmonary bioadhesive drug delivery systems.
This volume provides a thorough insight into the chemistry and mechanism of ionic gelations of various ionic biopolysaccharides, like alginate, gellan gum, pectin, chitosan, carboxymethyl cellulose, etc., and the applications of various ionically gelled biopolysaccharides in drug delivery fields, with chapters emphasizing the recent advances in the field by the experts. This book will be of interest to graduate students and academic and industry researchers from pharmacy, biotechnology, bioengineering, biomedical and material sciences fields.
This book will describe current research on drug delivery systems that encompass four broad categories, namely: routes of delivery, delivery vehicles, payload, and targeting strategies. Where appropriate delivery vehicles and relevant release of specific agents in any of these categories in clinical application will be discussed. All chapters will highlight the translational aspects of the various technologies discussed and will provide insights into the advantages of such delivery systems over current ones in clinical or research use. Each technology reviewed in this book will have significant potential to improve patients' lives by enhancing the therapeutic efficacy of drugs. This book: Discusses the various factors that mitigate effective oral insulin delivery and the current status of research efforts to overcome these barriers along with recent clinical projections Examines the advantages and disadvantages of each drug delivery system Examines the standard method of accomplishing controlled drug release through the incorporation of the drugs within polymeric biomaterials such as capsules and microcapsules as well as other vehicles such as liposomes Discusses various controlled drug delivery systems, including sustained release delivery systems and pulse or delayed release, e.g. to target different regions of the gastrointestinal tract. In view of these wide-ranging technological areas, and the up-to-date discussions of opportunities and challenges associated with these applications, the book should provide readers from technology, materials science, pharmacology and clinical disciplines with very valuable information.
Alginate is extracted from brown algae and some bacteria. It is an abundant natural polysaccharide and usually exists as sodium salt. In this book, the authors present topical research in the study of the production, types and applications of alginate. Topics discussed include the application of alginates in cell and enzyme immobilisation; alginate based materials in environmental applications; cross-linked alginates for modified drug delivery applications; bacterial alginate production by fermentation and the preparation and functionalisation of alginate-based hydrogels.
Marine organisms have been under research for the last decades as a source for different active compounds with various biological activities and application in agriculture, pharmacy, medicine, environment, and industries. Marine polysaccharides from these active compounds are used as antibacterial, antiviral, antioxidant, anti-inflammation, bioremediations, etc. During the last three decades, several important factors that control the production of phytoplankton polysaccharides have been identified such as chemical concentrations, temperature, light, etc. The current book includes 14 chapters contributed by experts around the world; the chapters are categorized into three sections: Marine Polysaccharides and Agriculture, Marine Polysaccharides and Biological Activities, and Marine Polysaccharides and Industries.
Alginates are polysaccharides found in both the intercellular matrix of brown algae and extracellularly covering some species of bacteria. Alginate varies in composition of the algae from 20% to 60% dry matter, but on average brown algae species has 40% alginate. Alginate from brown algae occurs as gels containing sodium, calcium, strontium, magnesium, and barium ions. They are widely used by the food industry, giving foods texture properties such as thickening, adhesion, emulsification, gelling, or fullness. This book covers the latest uses of this phycocolloid in the pharmaceutical, medical, and technological fields, namely bioink for 3D bioprinting in tissue engineering and regenerative medicine, and the application of artificial intelligence in modern healthcare systems.