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A biography of a British World War II secret agent who escaped the Buchenwald concentration camp. One of the most determined and courageous secret agents of the Second World War, Harry Peulevé joined the BEF in 1940 before volunteering for F Section of the Special Operations Executive. On his first mission to occupied France to set up the SCIENTIST circuit, he broke his leg on landing and, after numerous close calls, made a heroic crossing of the Pyrenees on sticks in December, 1942. Imprisoned, he escaped and eventually returned to England in May, 1943. He formed a close friendship with Violette Szabo before setting out to train a Maquis group in central France. Despite the Gestapo’s repeated attempts to catch him, he built a secret army of several thousand resistance fighters. Eventually betrayed and captured, he was tortured at Avenue Foch but never broken. By coincidence, he and Violette met while in captivity before Harry was sent to Buchenwald where he not only avoided execution but also managed to escape, reaching American lines in April, 1945. Sadly, Peulevé never fully recovered from his wartime traumas, but nothing can detract from his outstanding courage and contribution.
This dramatic memoir traces Herman Bodson's transformation from a pacifist and scientist to, in his own words, "a cold fighter and a killer" in the Belgian underground, an expert in explosives and sabotage. Serving first in the OMBR (Office Militaire Belge de Resistance), he later formed a group of underground fighters in the Belgian Ardennes. They undertook blowing up military trains and installations - including the sabotage of a bridge which resulted in the deaths of some six hundred German soldiers - cutting German communication lines, and rescuing downed American fliers. Bodson also served as a medical aide to an American military doctor at Bastogne in the crucial days of the Battle of the Bulge.
The “lively and engrossing” (The Wall Street Journal) story of how OSS spymaster Allen Dulles built an underground network determined to take down Hitler and destroy the Third Reich. Agent 110 is Allen Dulles, a newly minted spy from an eminent family. From his townhouse in Bern, Switzerland, and in clandestine meetings in restaurants, back roads, and lovers’ bedrooms, Dulles met with and facilitated the plots of Germans during World War II who were trying to destroy the country’s leadership. Their underground network exposed Dulles to the political maneuverings of the Soviets, who were already competing for domination of Germany, and all of Europe, in the post-war period. Scott Miller’s “absorbing and bracing” (The Seattle Times) Agent 110 explains how leaders of the German Underground wanted assurances from Germany’s enemies that they would treat the country humanely after the war. If President Roosevelt backed the resistance, they would overthrow Hitler and shorten the war. But Miller shows how Dulles’s negotiations fell short. Eventually he was placed in charge of the CIA in the 1950s, where he helped set the stage for US foreign policy. With his belief that the ends justified the means, Dulles had no qualms about consorting with Nazi leadership or working with resistance groups within other countries to topple governments. Agent 110 is “a doozy of a dossier on Allen Dulles and his early days spying during World War II” (Kirkus Reviews). “Miller skillfully weaves a double narrative of Dulles’ machinations and those of the German resistance” (Booklist) to bring to life this exhilarating, and pivotal, period of world history—of desperate renegades in a dark and dangerous world where spies, idealists, and traitors match wits and blows to ensure their vision of a perfect future.
Fighting Multidrug Resistance with Herbal Extracts, Essential Oils and their Components offers scientists a single source aimed at fighting specific multidrug-resistant (MDR) microorganisms such as bacteria, protozoans, viruses and fungi using natural products. This essential reference discusses herbal extracts and essential oils used or under investigation to treat MDR infections, as well as those containing antimicrobial activity that could be of potential interest in future studies against MDR microorganisms. The need to combat multidrug-resistant microorganisms is an urgent one and this book provides important coverage of mechanism of action, the advantages and disadvantages of using herbal extracts, essential oils and their components and more to aid researchers in effective antimicrobial drug discovery Addresses the need to develop safe and effective approaches to coping with resistance to all classes of antimicrobial drugs Provides readers with current evidence-based content aimed at using herbal extracts and essential oils in antimicrobial drug development Includes chapters devoted to the activity of herbal products against herpes, AIDS, tuberculosis, drug-resistant cancer cells and more
Antimicrobial resistance (AMR) is a serious global health threat and a food safety issue of primary concern. Governments and international organizations have recognized that the issue has to be approached in a multidisciplinary manner, addressing animal, plant and human health as well as the environment under the One Health approach. This publication brings together the three Codex texts, two guidelines and a code of practice, that will support governments in designing and running a successful strategy to tackle foodborne AMR.
Antibacterial agents act against bacterial infection either by killing the bacterium or by arresting its growth. They do this by targeting bacterial DNA and its associated processes, attacking bacterial metabolic processes including protein synthesis, or interfering with bacterial cell wall synthesis and function. Antibacterial Agents is an essential guide to this important class of chemotherapeutic drugs. Compounds are organised according to their target, which helps the reader understand the mechanism of action of these drugs and how resistance can arise. The book uses an integrated “lab-to-clinic” approach which covers drug discovery, source or synthesis, mode of action, mechanisms of resistance, clinical aspects (including links to current guidelines, significant drug interactions, cautions and contraindications), prodrugs and future improvements. Agents covered include: agents targeting DNA - quinolone, rifamycin, and nitroimidazole antibacterial agents agents targeting metabolic processes - sulfonamide antibacterial agents and trimethoprim agents targeting protein synthesis - aminoglycoside, macrolide and tetracycline antibiotics, chloramphenicol, and oxazolidinones agents targeting cell wall synthesis - β-Lactam and glycopeptide antibiotics, cycloserine, isonaizid, and daptomycin Antibacterial Agents will find a place on the bookshelves of students of pharmacy, pharmacology, pharmaceutical sciences, drug design/discovery, and medicinal chemistry, and as a bench reference for pharmacists and pharmaceutical researchers in academia and industry.
Leading experts summarize and synthesize the latest discoveries concerning the changes that occur in tumor cells as they develop resistance to anticancer drugs, and suggest new approaches to preventing and overcoming it. The authors review physiological resistance based upon tumor architecture, cellular resistance based on drug transport, epigenetic changes that neutralize or bypass drug cytotoxicity, and genetic changes that alter drug target molecules by decreasing or eliminating drug binding and efficacy. Highlights include new insights into resistance to antiangiogenic therapies, oncogenes and tumor suppressor genes in therapeutic resistance, cancer stem cells, and the development of more effective therapies. There are also new findings on tumor immune escape mechanisms, gene amplification in drug resistance, the molecular determinants of multidrug resistance, and resistance to taxanes and Herceptin.