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Age-related Macular Degeneration (AMD) is the leading cause of vision loss and blindness in the developed countries. In the past decade, great progress has been made in understanding the pathobiology and genetics of this blinding disease, as well as in finding new therapies for its treatment. These include the discovery of several genes that are associated with the risk of AMD, new anti-VEGF treatments for wet AMD and new imaging techniques to diagnose and monitor the AMD. All chapters in this book were contributed by outstanding research scientists and clinicians in the area of AMD. I hope this timely book will provide the basic scientists and clinicians with an opportunity to learn about the recent advances in the field of AMD.
​This book provides the ophthalmologist with the most recently available data on the macular dystrophies, a group of many different inherited or sporadic eye conditions linked by a problem with photoreceptors or other structures of the central retina. Internationally recognized experts in the field present the latest evidence and discuss their own personal experiences with regard to each of the principal dystrophies as well as some very rare entities. Topics covered include molecular biology, state-of-the-art diagnostic techniques, and the newest treatment options, including still experimental therapies. Attention is also devoted to a range of issues that continue to be debated. The editors have taken care to ensure that chapters are of a uniformly high standard while not sacrificing the originality of the individual authors. Macular Dystrophies will fully acquaint the reader with both the latest research findings and the current and emerging approaches to diagnosis and treatment.
The editor of this volume, having research interests in the field of ROS production and the damage to cellular systems, has identified a number of enzymes showing ·OH scavenging activities details of which are anticipated to be published in the near future as confirmatory experiments are awaited. It is hoped that the information presented in this book on NDs will stimulate both expert and novice researchers in the field with excellent overviews of the current status of research and pointers to future research goals. Clinicians, nurses as well as families and caregivers should also benefit from the material presented in handling and treating their specialised cases. Also the insights gained should be valuable for further understanding of the diseases at molecular levels and should lead to development of new biomarkers, novel diagnostic tools and more effective therapeutic drugs to treat the clinical problems raised by these devastating diseases.
Handbook of Nutrition, Diet, and the Eye, Second Edition, thoroughly addresses common features and etiological factors on how dietary and nutritional factors affect the eye. The ocular system is perhaps one of the least studied organs in diet and nutrition, yet the consequences of vision loss are devastating. There are a range of ocular defects that have either their origin in nutritional deficiencies/excess or have been shown to respond favorably to nutritional components. Featuring a new section on animal model studies where both the ocular problem and dietary remedies can be varied, there are also new chapters on dietary supplements. - Serves as a foundational collection for neuroscience, neurology and nutrition researchers, illustrating the importance of nutrition and diet in eye health and function - Provides a common language for readers to discuss how nutritional factors and related diseases and syndromes affect the eye - Features new chapters on infectious diseases of the eye where nutrition is a factor - Discusses animal model studies, dietary supplements, natural dietary extracts from around the world, and age-related changes in ocular health
A renowned group of retina surgeons presents promising new developments in age-related macular degeneration, with emphasis on the most significant advances in the past five years. Content addresses all aspects of management, including anatomy, physiology, and pathophysiology; imaging of the macula in age-related macular degeneration; prevention measures and treatment; treatment; and future directions. Abundantly illustrated and superbly organized, this book serves as an excellent reference and textbook.
Rapid or even dramatic progress has been made in the field of AMD over recent years, leading to a constant revision of basic concepts. A wide range of fundus imaging modalities are now available, and this book explains the respective value of each technique. The information provided by OCT is presented logically by comparison with plain films, autofluorescence, fluorescein angiography, or indocyanine green angiography. Meticulous biomicroscopic examination of macular changes and the essential value of fluorescein angiography for the detection of anatomical alterations of the macula and for precise evaluation of lesions and their course by indocyanine green angiography have naturally led the author Gabriel Coscas to analyze the new data provided by OCT.
Retinal disease in general, and age-related macular degeneration (AMD) specifically, is of major interest worldwide due to the increasing aging population and the revolution in management of wet AMD over the past several years. Age-Related Macular Degeneration presents an up-to-date, clinically relevant monograph on the current diagnosis and management of AMD. Age-Related Macular Degeneration by Drs. Jay S. Duker and Andre J. Witkin serves as a reference for ophthalmologists treating AMD in the clinic as well as other eye care professionals who see and counsel patients with AMD. Chapters will focus on the pathogenesis and risk factors for AMD, the diagnosis of AMD, treatment options, and promising investigative interventions. To help readers gain familiarity recognizing AMD, the book contains multiple images in different formats: high quality color fundus photographs, black-and-white angiograms, black-and-white autofluorence images, and both color and black-and-white OCT images. Relevant to current management of AMD, Age-Related Macular Degeneration: Current Management concentrates on “clinical utility” rather than emphasizing published studies, filling the current void in the market for the general ophthalmology and optometry audience. Comprehensive ophthalmologists, optometrists and retinal specialists will appreciate the book’s practical approach to AMD.
The acclaimed book on macular degeneration—now completely revised and updated with cutting edge research and the latest developments in the field. More than fifteen million Americans have age-related macular degeneration (AMD), and the disease will strike 200,000 more people this year. It is the most prevalent cause of vision loss in the western world. Dr. Lylas Mogk, the founding director of the Visual Rehabilitation and Research Center of the Henry Ford Health System, has a unique professional and personal understanding of AMD. A doctor and loving daughter of a parent with this frightening though manageable condition, Mogk here explains exactly what it is and how to limit its effect on your life. Reassuring and comprehensive—complete with illuminating first person stories of people with AMD—Macular Degeneration will help you or someone you love with information on • Reducing your risk factors • Revolutionary new technology, including laser surgery and alternative treatments • New research discoveries in nutrition—and eye-healthy recipes • The latest low-vision computer software programs • Coping with depression and frustration • Active online communities of people with macular degeneration Plus a Low Vision Living Rehab program to help you read better, see better, and live independently!
A consolidated view of a complex disorder, Age-Related Macular Degeneration, summarizes the latest evidence-based studies and translates these advancements into practical, actionable knowledge. This concise resource covers the fundamentals of age-related macular degeneration (AMD) diagnosis and treatment along with a modern definition of the disorder that acknowledges the range of presentations that ophthalmologists see in real practice. Offering practical, clinical guidance in addition to capturing new therapeutic approaches in the pipeline, this book is an essential reference for ophthalmologists, optometrists, and researchers. - Takes a concise, yet comprehensive, approach to AMD, covering both basic science and clinical guidance. - Features clinical guidelines on the diagnosis and treatment of AMD, including classification, signs/symptoms, imaging, and differential diagnosis in the pre-optical coherence tomography (OCT) and modern OCT eras. - Presents up-to-date information on AMD therapies currently in the development pipeline and offers insights for the future of translational research. - Explains molecular genetics and pathogenic events of AMD from both basic and clinical perspectives, which may help readers seek promising new therapeutic targets - Contains more than 250 images, with multimodal imaging techniques that clearly demonstrate AMD pathophysiology and clinical pathology.