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T-cells are an essential component of the immune system that provide protection against pathogen infections and cancer and are involved in the aetiology of numerous autoimmune and autoinflammatory pathologies. Their importance in disease, the relative ease to isolate, expand and manipulate them ex vivo have put T-cells at the forefront of basic and translational research in immunology. Decades of study have shed some light on the unique way T-cells integrate extrinsic environmental cues influencing an activation program triggered by interactions between peptide-MHC complexes and the antigen-recognition machinery constituted of clonally distributed T-cell receptors and their co-receptor CD4 or CD8. The manipulation of these molecular determinants in cellular systems or as recombinant proteins has considerably enhanced our ability to understand antigen-specific T-cell activation, to monitor ongoing T-cell responses and to exploit T-cells for therapy. Even though these principles have given numerous insights in the biology of CD8+ T-cells that translate into promising therapeutic prospects, as illustrated by recent breakthroughs in cancer therapy, they have proven more challenging to apply to CD4+ T-cells. This Research Topic aims to provide a comprehensive view of the recent insights provided by the use of engineered antigen receptors and their ligands on T-cell activation and how they have been or could be harnessed to design efficient immunotherapies.
This third volume of the Selected Works focusses on a detailed study of fraction Brownian motions. The fractal themes of "self-affinity" and "globality" are presented, while extensive introductory material, written especially for this book, precedes the papers and presents a number of striking new observations and conjectures. The mathematical tools so discussed will be valuable to diverse scientific communities.
Mathematical, statistical, and computational methods enable multi-disciplinary approaches that catalyse discovery. Together with experimental methods, they identify key hypotheses, define measurable observables and reconcile disparate results. This volume collects a representative sample of studies in T cell immunology that illustrate the benefits of modelling-experimental collaborations and which have proven valuable or even ground-breaking. Studies include thymic selection, T cell repertoire diversity, T cell homeostasis in health and disease, T cell-mediated immune responses, T cell memory, T cell signalling and analysis of flow cytometry data sets. Contributing authors are leading scientists in the area of experimental, computational, and mathematical immunology. Each chapter includes state-of-the-art and pedagogical content, making this book accessible to readers with limited experience in T cell immunology and/or mathematical and computational modelling.
A comprehensive overview of recent progress in nonequilibrium statistical mechanics, including applications across a range of disciplines.
This essential handbook guides investigators in the theory, applications, and practical use of affinity chromatography in a variety of fields including biotechnology, biochemistry, molecular biology, analytical chemistry, proteomics, pharmaceutical science, environmental analysis, and clinical chemistry. The Handbook of Affinity Chromatograph
This book constitutes the refereed proceedings of the 18th European Conference on Machine Learning, ECML 2007, held in Warsaw, Poland, September 2007, jointly with PKDD 2007. The 41 revised full papers and 37 revised short papers presented together with abstracts of four invited talks were carefully reviewed and selected from 592 abstracts submitted to both, ECML and PKDD. The papers present a wealth of new results in the area and address all current issues in machine learning.
Many advances have been made in the last decade in the understanding of the computational principles underlying olfactory system functioning. Neuromorphic Olfaction is a collaboration among European researchers who, through NEUROCHEM (Fp7-Grant Agreement Number 216916)-a challenging and innovative European-funded project-introduce novel computing p
Assuming that the complex phenomena underlying the operation of the immune system may be better understood through the collaborative efforts of theorists and experimentalists viewing the same phenomena in different ways, the Sante Fe Institute and the Theoretical Division of Los Alamos National Laboratory cosponsored a workshop entitled "Theoretical Immunology". The workshop focused on themes spanning the field of immunology, with emphasis on areas where the theorists have made the most progress. This book covers the discussions a that workshop on the topics of immune surveillance, mathematical models of HIV infection, complexities of antigen-antibody systems, immune suppression and tolerance, and idiotypie networks. In each of these areas there is reason to believe that advances can be made either through interactions among experimentalists and theorists or through the critical look experimentalists and theorists will bring to bear upon one another's work.
Environmental Geochemistry: Site Characterization, Data Analysis, Case Histories, and Associated Health Issues provides a wealth of information on modern geochemical methods, techniques, and procedures for those studying toxic substances found in soil, air, and water. This new edition takes an especially close look at environmental pollution and its impact on human health. The first third of the book looks at a variety of methods and procedures, such as taking groundwater samples, biological monitoring, geochemical mapping, and models of geochemical speciation. This is followed by a close look at different pollutants, including lead and pesticides. The authors conclude with several detailed case histories examining health issues resulting from environmental pollution. Environmental researchers and practitioners will return to this book again and again in their work towards understanding and reducing the environmental pollutants that affect our health. - Provides an in-depth examinations of the latest geochemical techniques and procedures - Presents a detailed analysis of various applied studies in pollution and contamination - Includes new case histories that highlight environmental pollution and related health issues