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The World Health Organization (WHO) has now developed a target product profile (TPP) for the minimal and optimal characteristics of an aerosolized surfactant that can be used for neonates with respiratory distress syndrome (RDS) in low- and middle-income countries (LMICs). The purpose of the TPP is to guide product developers about key test characteristics and performance specifications that will meet the needs of end users in LMICs. It describes the minimal and optimal characteristics of an aerosolized surfactant for treatment of RDS in newborns in LMICs. The intended target audience is doctors, nurses, pharmacists, administrators, procurement officers, program managers, policy makers, members of academic organizations who care for preterm neonates.
Inhalation aerosols continue to be the basis for successful lung therapy for several diseases, with therapeutic strategies and the range of technology significantly evolving in recent years. In response, this third edition takes a new approach to reflect the close integration of technology with its application. After briefly presenting the general considerations that apply to aerosol inhalation, the central section of the book uses the focus on disease and therapeutic agents to illustrate the application of specific technologies. The final integrated strategies section draws the major points from the applications for disease targets and drug products.
This book presents detailed fundamentals of surfactant systems and links these fundamentals to emerging perspectives in the field of surfactant science. Key topics include environmentally friendly surfactants, ionic liquid-based surfactants, chemically enhanced oil recovery, synergy of surfactants with clay minerals, and reactions in microheterogeneous surfactant systems. This book is an excellent resource for students, researchers, and industry professionals.
Integrating basic and clinical research on the biophysical and physiological functions of pulmonary surfactants, this practical reference presents thorough, cutting-edge coverage on surfactant-related lung disease. Manage neonatal respiratory distress syndrome (RDS), acute respiratory distress syndrome (ARDS), and acute lung injury more effectively!
Take the easiest path to respiratory pharmacology mastery with Rau’s Respiratory Care Pharmacology, 9th Edition. With broken-down terminology, relatable explanations, and reader-friendly writing, Rau simplifies the process of learning pharmacology material like never before to prepare you for success on your exams and in professional practice! This new edition includes the most recent advances related to apneic and asthmatic pharmacology, twice the number of clinical scenarios, more drug formulation tables, and a new mobile app for interactive drug flashcards. Enhanced readability helps readers more easily understand difficult material. Full-color design makes the text more reader-friendly and helps the learner to identify relevant details within an illustration. Learning objectives parallel the levels tested by the NBRC exams to help readers identify important information that goes beyond memorization and recall. Key terms with definitions provide easy access to the pharmacologic vocabulary readers should embrace. Key points in each chapter highlight important concepts in the lesson. Self-assessment questions offer readers the opportunity to test themselves on content learned with thought-provoking questions that require short answers. Clinical scenarios with follow-up SOAP assessment help readers assess their comprehension of the material. Glossary of all key terms in the text aids readers in understanding the terminology associated with respiratory care pharmacology. Appendices on common units, systems of measurement, and acceptable mixtures provides references to need-to-know information such as abbreviations, conversion charts for temperatures, liquid metric and solids, and a simple drug compatibility chart for drug mixtures. Alphabetical drug index offers a direct index to look up information based on drug name. NEW! Recent advances related to apneic and asthmatic pharmacology familiarize readers with current information. NEW! Twice the number of clinical scenarios engages the reader and helps them apply what they have learned. NEW! Mobile app for interactive drug flashcards provides a more technology-savvy, portable approach to the study and review of respiratory pharmacology. NEW! More drug formulation tables that include drug categories, brand names, and dosages provide a go to reference for better consistency and readability.
The latest edition of this popular book covers the “how-to” of respiratory care of newborns. Chapters from the previous edition have been updated to reflect advances in both equipment and practice, while newer chapters reflect the evolving worldwide approaches to neonatal respiratory failure, such as sustained inflation, optimization of lung volume, and the use of volumetric capnography, aerosol therapy, and management of chylothorax. New additions to the book also include chapters on assessment of large data bases, implementation of quality improvement programs in neonatal respiratory care, chronic ventilation of the baby with non-respiratory failure. The text also features case studies for self-review and is illustrated with high quality radiographic images, figures, tables, and algorithms. Written and edited by international experts, the Manual of Neonatal Respiratory Care, Fourth Edition is a thorough update and remains a convenient source of practical information on respiratory physiology, exam techniques, tips for performing procedures, radiography, ventilation, pain management, transport, and discharge planning.
A needed resource for pharmaceutical scientists and cosmetic chemists, Essential Chemistry for Formulators of Semisolid and Liquid Dosages provides insight into the basic chemistry of mixing different phases and test methods for the stability study of nonsolid formulations. The book covers foundational surface/colloid chemistry, which forms the necessary background for making emulsions, suspensions, solutions, and nano drug delivery systems, and the chemistry of mixing, which is critical for further formulation of drug delivery systems into semisolid (gels, creams, lotions, and ointments) or liquid final dosages. Expanding on these foundational principles, this useful guide explores stability testing methods, such as particle size, rheological/viscosity, microscopy, and chemical, and closes with a valuable discussion of regulatory issues. Essential Chemistry for Formulators of Semisolid and Liquid Dosages offers scientists and students the foundation and practical guidance to make and analyze semisolid and liquid formulations. - Unique coverage of the underlying chemistry that makes possible stable dosages - Quality content written by experienced experts from the drug development industry - Valuable information for academic and industrial scientists developing topical and liquid dosage formulations for pharmaceutical as well as skin care and cosmetic products
Biomaterials have had a major impact on the practice of contemporary medicine and patient care. Growing into a major interdisciplinary effort involving chemists, biologists, engineers, and physicians, biomaterials development has enabled the creation of high-quality devices, implants, and drug carriers with greater biocompatibility and biofunctiona