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A comprehensive book that reviews advances in ocular motor research on topics of general interest, rare, specialized or unique conditions, and pertinent basic neuroscience. A rare collection with contributions from basic neuroscientists, neurologists, and ophthalmologists. Includes dedicated chapters on mathematical models, pharmacotherapy, neuromodulation, motion perception, visual influence on eye movement, physiology of strabismus, and microsaccades. This book is dedicated to David Robinson - one of the pioneers of contemporary ocular motor and vestibular neuroscience.
A comprehensive book that reviews advances in ocular motor research on topics of general interest, rare, specialized or unique conditions, and pertinent basic neuroscience. A rare collection with contributions from basic neuroscientists, neurologists, and ophthalmologists. Includes dedicated chapters on mathematical models, pharmacotherapy, neuromodulation, motion perception, visual influence on eye movement, physiology of strabismus, and microsaccades. This book is dedicated to David Robinson - one of the pioneers of contemporary ocular motor and vestibular neuroscience.
Conn's Translational Neuroscience provides a comprehensive overview reflecting the depth and breadth of the field of translational neuroscience, with input from a distinguished panel of basic and clinical investigators. Progress has continued in understanding the brain at the molecular, anatomic, and physiological levels in the years following the 'Decade of the Brain,' with the results providing insight into the underlying basis of many neurological disease processes. This book alternates scientific and clinical chapters that explain the basic science underlying neurological processes and then relates that science to the understanding of neurological disorders and their treatment. Chapters cover disorders of the spinal cord, neuronal migration, the autonomic nervous system, the limbic system, ocular motility, and the basal ganglia, as well as demyelinating disorders, stroke, dementia and abnormalities of cognition, congenital chromosomal and genetic abnormalities, Parkinson's disease, nerve trauma, peripheral neuropathy, aphasias, sleep disorders, and myasthenia gravis. In addition to concise summaries of the most recent biochemical, physiological, anatomical, and behavioral advances, the chapters summarize current findings on neuronal gene expression and protein synthesis at the molecular level. Authoritative and comprehensive, Conn's Translational Neuroscience provides a fully up-to-date and readily accessible guide to brain functions at the cellular and molecular level, as well as a clear demonstration of their emerging diagnostic and therapeutic importance. - Provides a fully up-to-date and readily accessible guide to brain functions at the cellular and molecular level, while also clearly demonstrating their emerging diagnostic and therapeutic importance - Features contributions from leading global basic and clinical investigators in the field - Provides a great resource for researchers and practitioners interested in the basic science underlying neurological processes - Relates and translates the current science to the understanding of neurological disorders and their treatment
There is perhaps no area of neuro-ophthalmology that is advancing more rapidly with respect to an understanding of its anatomy and physiology than the ocular motor system. For this reason, it is difficult not only to keep up with the latest information concerning the basic mechanisms involved in the control of eye movements but also to remain up to date regarding the pathophysiology of specific disorders of eye movement. The material in this book is derived from a two-day course on eye movements held in The Netherlands in 1986. The course was designed as an introduction to the normal ocular motor system and to disorders of eye movements and was aimed toward orthoptists, ophthalmolo gists, optometrists, neurologists, and neurosurgeons. The chapters in this book were compiled by a trio of experts in the field of eye movements and contain discussions of anatomy and physiology of the ocular motor system, techniques of examination of patients with diplopia, and pathophysiology of specific disorders of ocular motility. Many of the authors of these chapters are among the most active investigators of eye movements in the world today, and their comments thus reflect the latest information in the field. This text is both basic and com prehensive and thus has something for everyone, from the student just beginning a study of the ocular motor system to the seasoned 'veteran' who wishes to know the latest information regarding central ocular motor control mechanisms. Neil R.
This edited volume presents fundamentals as well as applications of oculomotor methods in industrial and clinical settings. The topical spectrum covers 1.) basics and background material, 2.) methods such as recording techniques, markov models, Lévy flights, pupillometry and many more, as well as 3.) a broad range of applications in clinical and industrial settings. The target audience primarily comprises research experts and practitioners, but the book may also be beneficial for graduate students.
The Neurology of Eye Movements provides clinicians with a synthesis of current scientific information that can be applied to the diagnosis and treatment of disorders of ocular motility. Basic scientists will also benefit from descriptions of how data from anatomical, electrophysiological, pharmacological, and imaging studies can be directly applied to the study of disease. By critically reviewing such basic studies, the authors build a conceptual framework that can be applied to the interpretation of abnormal ocular motor behavior at the bedside. These syntheses are summarized in displays, new figures, schematics and tables. Early chapters discuss the visual need and neural basis for each functional class of eye movements. Two large chapters deal with the evaluation of double vision and systematically evaluate how many disorders of the central nervous system affect eye movements. This edition has been extensively rewritten, and contains many new figures and an up-to-date section on the treatment of abnormal eye movements such as nystagmus. A major innovation has been the development of an option to read the book from a compact disc, make use of hypertext links (which bridge basic science to clinical issues), and view the major disorders of eye movements in over 60 video clips. This volume will provide pertinent, up-to-date information to neurologists, neuroscientists, ophthalmologists, visual scientists, otalaryngologists, optometrists, biomedical engineers, and psychologists.
“This updated edition, with its latest treatments and a primer on deep brain stimulation, is helpful for clinicians dealing with movement disorders. It will be an excellent addition to the library of those who see movement disorders." ---Doody's Review Service, 5 stars Revised Third Edition of the practical yet authoritative guide to diagnosis and treatment of movement disorders. Written in an expanded outline format, this book is packed with flow charts, algorithms, and tables to provide quick access to point-of-care information. Easy-to-read and thoroughly up-to-date, this new edition includes the latest diagnostic and treatment protocols, recent FDA-approved drugs, and non-pharmacological therapies. With coverage of all major disease categories, this essential handbook belongs in the pocket of any clinician who suspects a movement disorder in a patient. The book is organized by medical, behavioral, surgical, and non-pharmacological treatment approaches to movement disorders. Opening chapters walk the practitioner through clinical presentation, diagnosis, and work-up of common and uncommon disorders, sleep-related movement disorders, eye and vestibular function, including pediatric issues. Behavioral and psychiatric complications for Parkinson disease, Huntington disease, and Tourette syndrome follow, with a fully reconfigured chapter on functional movement disorders, incorporating changes in classification and treatment approach. Expanded chapters on surgical devices and indications address deep brain stimulation surgery; lesioning, shunts, and pumps; post-operative care; and neuropsychological, social, and ethical issues. The final section on non-pharmacological approaches covers physical and occupational therapy, speech and swallowing therapy, nutrition, and palliative care. Key Features: Thoroughly revised and updated third edition of popular practical resource for busy clinicians Incorporates most recent evidence for the pharmacological, behavioral, surgical, and non-pharmacological treatment of the full spectrum of movement disorders Expanded bullet-point outline format for quick access to essential information Loaded with illustrative flow charts, algorithms, and tables outlining drug dosing, side effects, and other therapeutic treatments
This book describes the abnormal eye movements encountered in the critical care unit in everyday practice and elaborates on the mechanism and clinical significance behind them. Beginning with a thorough grounding of the basic anatomy and physiology ocular motor system and how they move the eyeballs; chapters explore the pathological descriptions of all the signs that a practicing neurologist, ophthalmologist, or emergency medicine specialist might see in other ICU's, as well as the diagnostic and prognostic evidence to answer the consult questions. Further chapters describe the abnormal ocular movements seen in the Neuro-ICU, Eye Movements in the Critical Care Setting is a comprehensive resource on eye movement in the critical care setting, and a useful guide for the neurologist, ophthalmologist, and emergency medical specialist and residents alike.
Nervous system diseases and disorders are highly prevalent and substantially contribute to the overall disease burden. Despite significant information provided by the use of animal models in the understanding of the biology of nervous system disorders and the development of therapeutics; limitations have also been identified. Treatment options that are high in efficacy and low in side effects are still lacking for many diseases and, in some cases are nonexistent. A particular problem in drug development is the high rate of attrition in Phase II and III clinical trials. Why do many therapeutics show promise in preclinical animal models but then fail to elicit predicted effects when tested in humans? On March 28 and 29, 2012, the Institute of Medicine Forum on Neuroscience and Nervous System Disorders convened the workshop "Improving Translation of Animal Models for Nervous System Disorders" to discuss potential opportunities for maximizing the translation of new therapies from animal models to clinical practice. The primary focus of the workshop was to examine mechanisms for increasing the efficiency of translational neuroscience research through discussions about how and when to use animal models most effectively and then best approaches for the interpretation of the data collected. Specifically, the workshop objectives were to: discuss key issues that contribute to poor translation of animal models in nervous system disorders, examine case studies that highlight successes and failures in the development and application of animal models, consider strategies to increase the scientific rigor of preclinical efficacy testing, explore the benefits and challenges to developing standardized animal and behavioral models. Improving the Utility and Translation of Animal Models for Nervous System Disorders: Workshop Summary also identifies methods to facilitate development of corresponding animal and clinical endpoints, indentifies methods that would maximize bidirectional translation between basic and clinical research and determines the next steps that will be critical for improvement of the development and testing of animal models of disorders of the nervous system.