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This important book provides new information about the inter-disciplinary field of tissue banking and related clinical applications, and complements the previous two volumes. It gives comprehensive coverage of the regulatory framework of the subject, as well as production and sterilisation of tissue allografts (bone, skin and new substitutes). The use of tissue allografts in orthopaedic and replacement surgery for the treatment of burns, etc. is described.
This important book provides the only published information in the inter-disciplinary field of tissue banking. It gives comprehensive coverage of the regulatory framework of the subject, as well as production and sterilisation of tissue allografts, (bone, skin and new substitutes). The use of tissue allografts in orthopaedic and replacement surgery for the treatment of burns. etc. is described.
Advances in Tissue Banking is the only series of publications where producers and clinical users of tissues can learn in one place about developments in this interdisciplinary field. This important volume concentrates on the new leading topics, and bridges the tissue banking technology and the scientific developments, which fuel this rapidly growing field. It presents the regulatory controls being introduced in the USA, Europe and Japan, as well as the relationship among technical orthopaedics, in vitro tissue engineering, and osteoinduction. New subject areas in the volume include cell processing and preservation, particularly for islet and stem cells; preservation, processing and viability of vascular grafts; and gland transplantation. Collagen biochemistry is reviewed and linked to skin substitutes and skin banking. The volume fully reflects present global developments, with contributions from Spain, Japan, Russia, Poland, Estonia and the USA, among other countries.
This series has now established itself as the leading publication on the multi-disciplinary subject of tissue banking. The high quality of the contributors and the broad coverage of the subject have continued in Volume 4. The material given in this volume is not presented anywhere else as systematically or as authoritatively.The essential feature in establishing confidence in the quality and safety of allografts is the manufacturing quality system utilised. This volume describes the most recent approach to good manufacturing control.Throughout the world, the old cottage approach to tissue banking is being abandoned, mainly due to the insistence by regulatory authorities that the procedures should be standardised and rigorous infection control applied. The experience in a number of countries is described in this volume, giving the reader quick access to developments in Argentina, Finland, Indonesia, Scotland and France. These represent a geographical and cultural spread of the developments.A balance needs to be struck between the use of allografts and of bone substitutes, depending on the clinical condition and the availability of grafts in a particular situation. The subject areas — such as mandibular reconstruction, spinal surgery, surgery and reconstruction of bone tumours and acetabular revision — covered in this volume demonstrate the universality of this technique. The use of allografts for the repair of knee ligaments has been and remains a controversial subject. The contributions on this subject will surely be an important and positive addition to this debate.
Advances in Tissue Banking is the only series of publications where producers and clinical users of tissues can learn in one place about developments in this interdisciplinary field. This important volume concentrates on the new leading topics, and bridges the tissue banking technology and the scientific developments, which fuel this rapidly growing field. It presents the regulatory controls being introduced in the USA, Europe and Japan, as well as the relationship among technical orthopaedics, in vitro tissue engineering, and osteoinduction. New subject areas in the volume include cell processing and preservation, particularly for islet and stem cells; preservation, processing and viability of vascular grafts; and gland transplantation. Collagen biochemistry is reviewed and linked to skin substitutes and skin banking. The volume fully reflects present global developments, with contributions from Spain, Japan, Russia, Poland, Estonia and the USA, among other countries.
This book is a comprehensive guide for all tissue bank operators to screen, procure and process amniotic membrane for clinical application.The amnion comes close to being the ideal biological membrane or dressing — readily available, inexpensive to procure and process. Its basic science is discussed in detail — anatomy, biological and biomechanical properties.It can be procured from the placenta in normal vaginal deliveries and from Caesarean Sections. Processing is by freeze-drying or by air-drying process with sterilisation using gamma irradiation.The product has low antigenicity, has anti-microbial properties with ability to enhance epithelisation with marked relief of pain. It is useful as a dressing for wounds — flap wounds, burn wounds, injury wounds, diabetic ulcers, leprous ulcers and post-surgery wounds and post-radiation wounds. It is also used as a biological scaffold for cells in tissue engineering. Its ophthalmic applications include treatment of corneal ulcers and conjunctival tumours. Oral uses include gingiva depigmentation and periodontal regeneration.
This book provides the latest updates on the major challenges of bridging large bone defects, where options range from autografts, “tissue engineered bone”, biomaterials (hydroxyapatite, polycaprolactone and third generation biomaterials) to prostheses. Emphasis has been made on bone tissue engineering, the current state-of-the-art in this field, problems encountered with cell culture technology, scaffolds and bone growth factors (including genomics) and the use of gene therapy for the application of bone growth factors. Attention has also been given to the use of bone autografts. It also covers the use of biomaterials and prostheses as other options for reconstruction. Clinical applications, in addition to the basic science, are also included throughout the discussions.
This important book discusses the need for gamma irradiation in the processing of tissue allografts. With particular emphasis on tissue banking in the Asia-Pacific region, it covers a wide range of issues in tissue banking, including the basic science of radiation, quality control of the irradiation process, and clinical applications of irradiated bone grafts and amnions.A compulsory textbook for the well-regarded Singapore-based IAEA/NUS Diploma Course in Tissue Banking, it is also a useful guide for tissue bankers in establishing quality systems in their banks. Whether they be tissue banking students, tissue graft producers, radiation scientists, or transplantation surgeons, readers of this book will discover the latest developments in this exciting interdisciplinary field.
This important book contains in one volume various subjects, including anatomy, physiology, microbiology, radiation sciences, biology of healing of allografts, biomechanics of allografts and transplantation immunology. It is intended for easy and comprehensive use by practitioners in the field of tissue banking and tissue transplantation. It can also serve as a textbook for a course in tissue banking.
This book is written as a comprehensive guide for all tissue bank operators to procure and process bone and soft tissue allografts of highest quality standards for safe tissue transplantation practice in patients who require musculoskeletal tissue allograft transplantation. This comprehensive guide includes donor selection criteria, aseptic procurement techniques, laboratory testing and processing of grafts by deep freezing or freeze drying. It also includes sterilization of tissue grafts using gamma irradiation. Quality controls of tissue grafts are discussed in depth. The clinical transplantation of bone and soft tissue allografts is also discussed, with special consideration given to potential complications. Principles of sterile technique in the operating theater are described. The book also incorporates the basic sciences of tissue banking including anatomy, biomechanics, microbiology and immunology. It also covers radiation science so that the reader can better understand radiation sterilization of tissue grafts. Included in the book is a guide for public awareness programmes, radiation code of practice and general standards for tissue banking as recommended by the International Atomic Energy Agency.