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This is the second, completely updated edition of a comprehensive book in which many of the world’s leading lung cancer specialists discuss the recent advances in the radiation oncology of lung cancer and reflect on the latest research findings. The first three sections cover the basic science of lung cancer, clinical investigations, including histology and staging, and a wide range of fundamental treatment considerations. Current treatment strategies for small cell and non-small cell lung cancer are then explained and evaluated in detail, with due attention to novel approaches that promise further improvements in outcome. The various types of treatment-related toxicity are discussed, and quality of life studies and prognostic factors are also considered. After evaluating the latest technological and biological advances, including IMRT, IMAT, cyber knife treatment, and tomotherapy, the book concludes by thorough consideration of specific aspects of clinical research in lung cancer.
Although decades of laboratory and clinical research have led to incremental improvement in treatment outcome, lung cancer remains one of the most deadly diseases. This volume is unique in being devoted solely to the radiation oncology of lung cancer, and will be of great value to all who are involved in the diagnosis and treatment of the disease. Both non-small cell and small cell lung cancer are considered in detail. Current state-of-the-art treatment strategies and novel approaches that promise further improvements in outcome are explained and evaluated, with the aid of high-quality illustrations. Treatment-related toxicity is discussed, and further individual chapters focus on topics such as quality of life studies, prognostic factors and pitfalls in the design and analysis of clinical trials.
This book concisely reviews important advances in radiation oncology, providing practicing radiation oncologists with a fundamental understanding of each topic and an appreciation of its significance for the future of radiation oncology. It explores in detail the impact of newer imaging modalities, such as multiparametric magnetic resonance imaging (MRI) and positron emission tomography (PET) using fluorodeoxyglucose (FDG) and other novel agents, which deliver improved visualization of the physiologic and phenotypic features of a given cancer, helping oncologists to provide more targeted radiotherapy and assess the response. Due consideration is also given to how advanced technologies for radiation therapy delivery have created new treatment options for patients with localized and metastatic disease, highlighting the increasingly important role of image-guided radiotherapy in treating systemic and oligometastatic disease. Further topics include the potential value of radiotherapy in enhancing immunotherapy thanks to the broader immune-stimulatory effects, how cancer stem cells and the tumor microenvironment influence response, and the application of mathematical and systems biology methods to radiotherapy.
Developments in radiation oncology have been key to the tremendous progress made in the field in recent years. The combination of optimal systemic treatment and local therapy has resulted in continuing improved outcomes of cancer therapy. This progress forms the basis for current pre-clinical and clinical research which will strengthen the position of radiation oncology as an essential component of oncological care. This book summarizes recent advances in radiotherapy research and clinical patient care. Topics include radiobiology, radiotherapy technology, and particle therapy. Chapters cover a summary and analysis of recent developments in the search for biomarkers for precision radiotherapy, novel imaging possibilities and treatment planning, and advances in understanding the differences between photon and particle radiotherapy. Advances in Radiation Therapy is an invaluable source of information for scientists and clinicians working in the field of radiation oncology. It is also a relevant resource for those interested in the broad topic of radiotherapy in general.
Thoracic Malignancies: Thoracic Malignancies is the first title in Radiation Medicine Rounds. These tumors take more lives than any others and they are among the most preventable of tumors. Thus it is crucial for the practitioner to be up-to-date on the latest insights regarding their management. Thoracic Malignancies addresses the multi-disciplinary nature of the care of these tumors. There is representation from radiation oncology, medical oncology, and surgery ensuring a well-rounded summarization of current practice. Included are chapters on lung cancer, esophageal cancer, and thymomas providing coverage of the vast majority of thoracic tumors. The multi-disciplinary nature of the articles provides readers with an up-to-date summary and a well-rounded review regarding these tumors and their care. Expert authors provide reviews and assessments of the most recent data and its implications for current clinical practice, along with insights into emerging new trends of importance for the near future. About the Series Radiation Medicine Rounds is an invited review publication providing a thorough analysis of new scientific, technologic, and clinical advances in all areas of radiation medicine. There is an emphasis throughout on multidisciplinary approaches to the specialty, as well as on quality and outcomes analysis. Published three times a year Radiation Medicine Rounds provides authoritative, thorough assessments of a wide range of Ïhot topicsÓ and emerging new data for the entire specialty of radiation medicine. Features of Radiation Medicine Rounds include: Editorial board of nationally recognized experts across the spectrum of radiation medicine In-depth, up-to-date expert reviews and analysis of major new developments in all areas of Radiation Medicine Issues edited by an authority in specific subject area Focuses on major topics in Radiation Medicine with in-depth articles covering advances in radiation science radiation medicine technology, radiation medicine practice, and assessment of recent quality and outcomes studies Emphasizes multidisciplinary approaches to research and practice
This premier volume of Advances in Oncology highlights the latest findings and updates within the cancer field each year for the practicing oncologist. Advances in Oncology publishes the most current thinking and recent advances from the voice of a truly distinguished editorial board, including Editor-in-Chief Leonidas C. Platanias, who identify current advances and breakthroughs in the field and invite specialists to contribute original articles on these topics. Topics discussed in this first volume are within the areas of radiation oncology, surgical oncology, medical oncology, gynecologic oncology, pediatric oncology, neuro-oncology, hemato-oncology, uro-oncology, and gastrointestinal oncology. This volume will appeal to all practicing oncologists and will inform and enhance clinical practice.
Accelerated partial breast irradiation (APBI) is being rapidly introduced into the clinical management of early breast cancer. APBI, in fact, encompasses a number of different techniques and approaches that include brachytherapy, intraoperative, and external beam techniques. There is currently no single source that describes these techniques and their clinical implementation. This text is a concise handbook designed to assist the clinician in the implementation of APBI. This includes a review of the principles that underlie APBI, a practical and detailed description of each technique for APBI, a review of current clinical results of APBI, and a review of the incidence and management of treatment related complications.
This is the third, completely updated edition of a comprehensive book in which many of the world’s leading lung cancer specialists discuss the recent advances in the radiation oncology of lung cancer and reflect on the latest research findings in lung cancer and other intrathoracic malignancies. Lung cancer remains the major cancer killer in both sexes worldwide. It is so despite significant progress in recent decades in both diagnostic and treatment approaches. New biological and technological advances in this field are now faster incorporated in the overall decision-making process and are bringing fast and substantial improvements in both survivals and quality of life of lung cancer patients. Optimized patient-oriented approaches are reality of the third decade of this millennium and thoracic oncologists strive towards nothing but seamlessly delivering it in a continuous battle with lung cancer. The first three sections of the work cover the basic science of lung cancer, clinical investigations, including histology and staging, and a wide range of fundamental treatment considerations. Current treatment strategies for small cell and non-small cell lung cancer as well as other intrathoracic malignancies are then explained and evaluated in detail, with due attention to novel approaches that promise further improvements in outcome. The various types of treatment-related toxicity are discussed, and quality of life studies and prognostic factors are also considered. After evaluating the latest technological and biological advances, including stereotactic radiotherapy, and particle therapy, the book concludes by thorough consideration of specific aspects of clinical research in lung cancer. This concise yet comprehensive book is an invaluable resource for radiation oncologists.
This book describes the molecular mechanisms of lung cancer development and progression that determine therapeutic interventions in the era of genomics, when the rapid evolution in lung cancer diagnosis and treatment necessitates critical review of new results to integrate advances into practice. The text opens with background and emerging information regarding the molecular biology of lung cancer pathogenesis. Updated results regarding lung cancer prevention and screening are discussed, followed by chapters on diagnostic techniques and pathological evaluation. This leads on to a detailed presentation of treatment modalities, from surgery and radiation therapy to standard chemotherapy and targeted agents. The coverage includes resistance to therapy and the emergence of immunotherapy for lung cancer; in addition, the current evidence in respect of small cell lung cancer is summarized. The book presents insights from experts across disciplines to emphasize the importance of collaborative care. Advances in our understanding of issues in geriatric oncology and palliative care complete the comprehensive discussion of lung cancer.
Modern Thoracic Oncology is the first comprehensive publication on thoracic oncology. Contributors who are world experts have authored concise, relevant and current topics in this field. Whether one desires information regarding lung cancer screening, esophageal cancer staging, mutational analysis, targeted therapies, stereotactic ablative radiation with real-time imaging, minimally-invasive and robotic surgery, combination immunotherapy, microwave/cryoablation, or methods of early cancer detection, this set of three volumes, encompass all of the latest information in the field of thoracic oncology. A rapidly advancing knowledgebase has led to dramatic improvements in individualized or 'personalized' care of patients. However, the myriad of rapid changes has also made it more challenging for thoracic oncologists to comprehend and incorporate these improvements into their daily practice. This staggering and rapid change requires a comprehensive thoracic oncology publication designed to keep clinicians, including pulmonologists, pathologists, radiologists, surgeons, medical oncologists, radiation oncologists and gastroenterologists, well-informed and up-to-date. To meet such needs and to ensure that all areas of thoracic oncology are covered indepth, Modern Thoracic Oncology is published in three volumes.Volume 1 entitled General Principles of Thoracic Oncology provides a comprehensive introduction to thoracic oncology. Principles of thoracic oncology care are discussed in detail and include topics such as thoracic anatomy and embryology, medical evaluation of cancer patients, appropriate imaging modalities with a specific discussion of lung cancer screening, and the basic principles underlying the various treatment modalities. Volume 2 entitled Trachea, Lung, and Pleura addresses lung cancer, one of the most common and deadliest malignancies in the world, as well as two relatively rare respiratory tumors. Volume 3 entitled Esophagus, Mediastinum, Chest Wall and Diaphragm covers esophageal cancer, one of the most rapidly growing malignancies in the world and which still poses significant challenges to thoracic oncologists. Esophageal squamous cell tumors are discussed by experts from Asia where this disease is endemic and adenocarcinoma of the esophagus is detailed by oncologists in the West who face this challenge on a daily basis.