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This comprehensive reference work, updated from the first edition, brings together the knowledge and expertise of contributors from around the world. It includes new topics such as prostaglandin synthetase enzyme, new synthetic eicosanoids, innovative analytical methods, the influence of cytokines in the regulation of synthesis and actions, newer eicosanoids that influence the cardiovascular system, and newly discovered roles in reproduction and interactions with nitric oxide. This book satisfies a surge of interest in prostaglandins—NSAIDS (e.g. aspirin) are the biggest selling drugs of all time, and the field has been refreshed by the advent of new types (selective COX-2 inhibitors, anti-leukotiene drugs).
Over the last few years, we have witnessed tremendous progress in the field of eicosanoids and their therapeutic applications. Receptor an tagonists for leukotrienes have been tested as anti-inflammatories and are on the market as a treatment for asthma. Receptor agonists for pro stacyclin are being tested for the treatment of peripheral vascular dis ease, and selective inhibitors of cyclooxygenase type II were just ap proved for the treatment of rheumatoid arthritis. All these developments are the culmination of many years and man-hours of careful research. The field has now entered an upswing that will result in novel thera peutic applications within the next 10 years. New molecules and me diators have been identified, new enzymes and pathways elucidated and new therapeutic approaches have emerged. The concept of ei cosanoids as "pro-inflammatory" molecules is being challenged, and their role as regulators is increasingly recognized. In fact, some of these molecules may be important endogenous anti-inflammatory agents.
Rodd's Chemistry of Carbon Compounds, Volume II: Alicyclic Compounds surveys advances in the chemistry of three- to six-membered monocarbocycles from 1973 to 1991. This book begins with a detailed review of the conformations and stereochemical analyses of alicycles, including higher members of the series, and then proceeds to deal with the chemistry of individual ring systems. The next chapters cover the prostaglandins and their allies and natural products bearing a cyclohexane, cyclohexene, or cyclohexadiene ring system. A review of the chemistry of the cyclohexadienes and their metallic complexes is provided at the end. This text also includes a list of common abbreviations and symbols. This volume benefits chemical engineering students, particularly those studying the components of organic chemicals.
One hundred papers treat advances in research of the effects and uses of prostaglandins, thromboxanes, and leukotrienes in such medical fields as organ transplantation, male erectile dysfunction, amniotic fluid infection and labour, renal function, anti-inflammatory drugs, allergic and aspirin-intolerant asthma, angioplasty and heart ischemia, Alzheimer's disease, vessel wall hyperplasia, and more. Annotation copyrighted by Book News, Inc., Portland, OR
Americans' health improved dramatically over the twentieth century. Public health programs for disease and injury prevention were responsible for much of this advance. Over the century, America's public health system grew dramatically, employing science and political authority in response to an increasing array of health problems. As the disease burden of the old scourges of infection, perinatal mortality, and dietary deficiencies began to lift, public health's mandate expanded to take on new health threats, such as those resulting from a changing workplace, the rise of the automobile, and chronic and complex conditions caused by smoking, diet and other lifestyle and environmental factors. Public health measures almost always occur on contested ground; accordingly, controversies and recriminations over past failures often persist. In contrast, public health's many successes, even the imperfect ones, become part of the fabric of everyday life, a fact already apparent early in the last century, when C.E.A. Winslow reminded his peers that the lives saved and healthy years extended were the "silent victories" of public health. In its exploration of ten major public health issues addressed in the 20th century, Silent Victories takes a unique approach: for each issue, leading scientists in the field trace the discoveries, practices and programs that reduced morbidity and mortality from disease and injury, and an accompanying chapter by a historian or social scientist highlights key moments or conflicts that shaped public health action on that issue. The book concludes with a look toward the challenges public health must face in the future. Silent Victories reveals the lessons of history in a format designed to appeal to students, health professionals and the public seeking to understand how public health advanced the country's health in the 20th century, and the challenges to protecting health in the future.
The first book to offer a blueprint for overcoming the challenges to successfully quantifying biomarkers in living organisms The demand among scientists and clinicians for targeted quantitation experiments has experienced explosive growth in recent years. While there are a few books dedicated to bioanalysis and biomarkers in general, until now there were none devoted exclusively to addressing critical issues surrounding this area of intense research. Target Biomarker Quantitation by LC-MS provides a detailed blueprint for quantifying biomarkers in biological systems. It uses numerous real-world cases to exemplify key concepts, all of which were carefully selected and presented so as to allow the concepts they embody to be easily expanded to future applications, including new biomarker development. Target Biomarker Quantitation by LC-MS primarily focuses on the assay establishment for biomarker quantitation—a critical issue rarely treated in depth. It offers comprehensive coverage of three core areas of biomarker assay establishment: the relationship between the measured biomarkers and their intended usage; contemporary regulatory requirements for biomarker assays (a thorough understanding of which is essential to producing a successful and defendable submission); and the technical challenges of analyzing biomarkers produced inside a living organism or cell. Covers the theory of and applications for state-of-the-art mass spectrometry and chromatography and their applications in biomarker analysis Features real-life examples illustrating the challenges involved in target biomarker quantitation and the innovative approaches which have been used to overcome those challenges Addresses potential obstacles to obtain effective biomarker level and data interpretation, such as specificity establishment and sample collection Outlines a tiered approach and fit-for-purpose assay protocol for target biomarker quantitation Highlights the current state of the biomarker regulatory environment and protocol standards Target Biomarker Quantitation by LC-MS is a valuable resource for bioanalytical scientists, drug metabolism and pharmacokinetics scientists, clinical scientists, analytical chemists, and others for whom biomarker quantitation is an important tool of the trade. It also functions as an excellent text for graduate courses in pharmaceutical, biochemistry and chemistry.