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This is the fourth in a series of books on Advances in Prostaglandin Research published by MTP Press. From laboratory and animal studies a large number of practical applications of prostaglandins have been identified. In some areas clinical trials have also been carried out. There is usually a long time interval between identifying practical applications of new drugs and clinical trials. Most of the information on practical applications of prostaglandins is scattered in different journals. Although a number of books dealing with prostaglandin research have been published (including some on practical applications in specific areas, e.g. reproduction) there is no single volume dealing with all areas of practical applications of these substances. This book aims at filling this gap and should be of interest to clinicians as well as to medical and basic scientists in academic institutions and in the pharmaceutical industry. In some areas, exciting potential applications of prostaglandins have been identified from basic research but clinical trials have so far not been carried out. Such areas of practical applications are covered in a separate intro ductory chapter. All contributors to the volume are scientists and clinicians actively engaged in prostaglandin research and most are recognized authorities in specific areas. The need for rapid publication in a fast-expanding field is obvious.
It is clear today that several prostaglandins play an important role in the regulation of many of the physiological events of the reproductive organs in the human. Both naturally occurring prostaglandins and their analogues are used routinely in many countries to ripen the cervix and induce labour at term as well as to dilate the cervix and to terminate pregnancy. Prostaglandin biosynthesis inhibitors are widely used in the treatment of primary dysmenorrhoea. The editors have aimed at an accurate, thorough, yet easily under standable review of the status in 1986 of medical knowledge regarding both the physiological importance and the clinical use of prostaglan dins and their inhibitors in obstetrics and gynaecology. I believe this book will be of value for all clinicians concerned with reproductive health. The list of authors guarantees an authoritative and up-to-date review of this active field. SUNE BERGSTROM Karolinska Institutet, Stockholm, Sweden Table Examples of clinical use of natural prostaglandins and some prostaglandin analogues Indications Prostaglandin Route of administration Manufacturer Dilatation of the cervix prior 15-methyl-PGF • Intramuscular Upjohn, USA 2 to vacuum aspiration 16-phenoxy-PGE methyl sulphonylamide Intramuscular Schering AG, West Germany 2 16,16-dimethyl-PGE methyl ester 1 Vaginal ONO, Japan; May & Baker, UK Second trimester abortion Intra -amniotic Upjohn, USA; ONO, Japan PGF 20 Upjohn, USA PGE Vaginal 2 Upjohn, USA 15-methyl-PGF 2.
The purpose of this book is to provide comprehensive coverage and an update of the major roles of eicosanoids in reproduction. It presents considerable evidence of the importance of lipoxygenase metabolites of arachidonic acid metabolism in reproductive processes. This interesting volume embraces a multidisciplinary approach to research in reproduction (biochemistry, endocrinology, physiology, pharmacology, etc.) at all levels, from whole animal studies through organ, cellular, and molecular approaches. This one-of-a-kind work provides several clinically relevant chapters and places emphasis on the relevance to human reproduction, when applicable. This text is an excellent update for researchers and clinicians on the current state of knowledge of the role of eicosanoids in mechanisms critical for successful reproductive function. This informative, easy-to-read resource is also useful to all those with a more specific interest in obstetrics, gynecology, clinical endocrinology, and the study of fertility.
The state of health care isreflected by perinatal and neonatal morbidity and mortality as weIl as by the frequencies of long-term neurological and developmental disorders. Many factors, some without immediately recognizable significance to childbearing and many still unknown, undoubtedly contribute beneficially or adversely to the outcome of pregnancy. Knowledge concerning the impact of such factors on the fetus and survivinginfant iscritical. Confounding analysesofpregnancy outcome, especially these past 2 or 3 decades, are the effects of newly undertaken invasive or inactive therapeutic approaches coupled with the advent of high technology. Many innovations have been introduced without serious efforts to evaluate their impact prospectively and objectively. The consequences of therapeutic misadventures character ized the past; it seems they have been replaced to a degree by some of the complications of applied technology. Examples abound: after overuse of oxygen was recognized to cause retrolental fibroplasia, its restriction led to an increase in both neonatal death rates and neurologic damage in surviving infants. Administration of vitamin K to prevent neonatal hemorrhagic disease, particularly when given in what we now know as excessive dosage, occasionally resulted in kernicterus. Prophy lactic sulfonamide use had a similar end result. More recent is the observation of bronchopulmonary dysplasia as a complication of re spirator therapy for hyaline membrane disease. The decade of the eighties opened with the all-time highest rate of cesarean section in the United States.
Minimize complications with Creasy and Resnik's Maternal-Fetal Medicine. This medical reference book puts the most recent advances in basic science, clinical diagnosis, and management at your fingertips, equipping you with the up-to date evidence-based guidelines and knowledge you need to ensure the best possible outcomes in maternal-fetal medicine. Consult this title on your favorite e-reader, conduct rapid searches, and adjust font sizes for optimal readability. Apply today’s best practices in maternal-fetal medicine with an increased emphasis on evidence-based medicine. Find dependable, state-of-the-art answers to any clinical question with comprehensive coverage of maternal-fetal medicine from the foremost researchers and practitioners in obstetrics, gynecology and perinatology. Take advantage of the most recent diagnostic advances with a new section on Obstetrical Imaging, complemented by online ultrasound clips as well as cross references and links to genetic disorder databases. Stay on top of rapidly evolving maternal-fetal medicine through new chapters on Recurrent Spontaneous Abortion, Stillbirth, Patient Safety, Maternal Mortality, and Substance Abuse, as well as comprehensive updates on the biology of parturition, fetal DNA testing from maternal blood, fetal growth, prenatal genetic screening and diagnosis, fetal cardiac malformations and arrhythmias, thyroid disease and pregnancy, management of depression and psychoses during pregnancy and the puerperium, and much more. Access the complete contents online at Expert Consult.
The third volume of Advances in Nutritional Research continues the precedent set in previous volumes of providing authoritative reviews on the current state of knowledge with respect to major topics of ongoing nutritional research. This series is designed to be of value to investigators engaged in fundamental research as well as to those involved in its application to problems in human and animal nutrition. This volume contains three chapters on recent developments in research on inorganic elements, including a review, by F. H. Nielsen, of the evidence for a requirement for additional trace elements; a conspectus, by C. E. Casey and K. M. Hambidge, on the occurrence of trace element deficiencies in man; and a description, by M. Janghorbani and V. R. Young, of new methods of assessing the bioavailability of minerals in the diet. There are also three chapters on current topics of lipid research. One (by F. D. Sauer) is devoted to the cardiopathic effects of certain dietary monoenoic fatty acids, another (by C. Galli) to the influence of diet on prostaglandin synthesis, and the third (by H. 0. Bang and J. Dyerberg) to an analysis of the role of the unusual polyunsaturated fatty acids found in marine oils in the prevention of ischemic heart disease.
Minimize complications with Creasy and Resnik's Maternal-Fetal Medicine.This medical reference book puts the most recent advances in basic science, clinical diagnosis, and management at your fingertips, equipping you with the up-to date evidence-based guidelines and knowledge you need to ensure the best possible outcomes in maternal-fetal medicine. "... Creasy & Resnik's Maternal-Fetal Medicine: Principles and Practice remains an authoritative reference book for clinical residents, fellows and practicing specialists in Maternal-Fetal Medicine." Reviewed by Ganesh Acharya , Feb 2015 Apply today's best practices in maternal-fetal medicine with an increased emphasis on evidence-based medicine. Find dependable, state-of-the-art answers to any clinical question with comprehensive coverage of maternal-fetal medicine from the foremost researchers and practitioners in obstetrics, gynecology and perinatology. Take advantage of the most recent diagnostic advances with a new section on Obstetrical Imaging, complemented by online ultrasound clips as well as cross references and links to genetic disorder databases. Stay on top of rapidly evolving maternal-fetal medicine through new chapters on Recurrent Spontaneous Abortion, Stillbirth, Patient Safety, Maternal Mortality, and Substance Abuse, as well as comprehensive updates on the biology of parturition, fetal DNA testing from maternal blood, fetal growth, prenatal genetic screening and diagnosis, fetal cardiac malformations and arrhythmias, thyroid disease and pregnancy, management of depression and psychoses during pregnancy and the puerperium, and much more. Access the complete contents online at Expert Consult. Your purchase entitles you to access the web site until the next edition is published, or until the current edition is no longer offered for sale by Elsevier, whichever occurs first. If the next edition is published less than one year after your purchase, you will be entitled to online access for one year from your date of purchase. Elsevier reserves the right to offer a suitable replacement product (such as a downloadable or CD-ROM-based electronic version) should access to the web site be discontinued.
Proceedings held April 1988. A comprehensive reference work on the most important recent advances in traditional areas of perinatology which gives special attention to interdisciplinary aspects. Subjects covered include: congenital abnormalities, nutrition, infections, new technologies, endocrinology, neurological development, renal pathology, perinatal monitoring, respiration, pharmacology and pharmacodynamics, exercise, sport and travel, cardiovascular pathophysiology, management of the under 1 kg baby, hypertension in pregnancy and initiation of labor. Annotation copyrighted by Book News, Inc., Portland, OR
This reference is a volume in the Handbook of Physiology, co-published with The American Physiological Society. Growth in knowledge about the microcirculation has been explosive with the field becoming fragmented into numerous subdisciplines and subspecialties. This volume pulls all of the critical information into one volume. - Meticulously edited and reviewed. Benefit: Provides investigators a unique tool to explore the significance of their findings in the context of other aspects of the microcirculation. In this way, the updated edition has a direct role in helping to develop new pathways of research and scholarship - Highlights the explosive growth in knowledge about the microcirculation including the biology of nitric oxide synthase (NOS), endothelial cell signaling, angiogenesis, cell adhesion molecules, lymphocyte trafficking, ion channels and receptors, and propagated vasomotor responses. Benefit: Microcirculatory biology has become fragmented into numerous sub-disciplines and subspecialties, and these reference reintegrates the information in one volume