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If observed from an objective, epistemological standpoint, medicine is not a science, at least not in its own right. The most important, key feature missing is repeatability, which makes the doctor’s job extremely difficult. Doctors are not scientists but are called upon to use the results of scientific research every day. Therefore, they must keep themselves updated, distinguish what is worth extricating from a huge amount of literature and use the data exclusively in the patients’ interest. To be effective, medicine must start from a correct, full understanding of problems, but particulate pollution leads to too many wrong diagnoses. This book, written by the discoverers of nanopathology, is the most advanced in the field. It focuses on how natural, occasionally generated, engineered particles interfere with living organisms, food, drugs and the environment. It represents a bridge between environmental pollution and its impact on human/animal/plant health. Also unique is its new bioengineering-interdisciplinary approach to medicine and solving pathologies of unknown aetiology. It is a valuable aid for medical doctors in their diagnoses of pathologies triggered by nanoparticles internalized in the human/animal/plant body. They will find solutions to some hardly understandable symptoms which some patients report.
If observed from an objective, epistemological standpoint, medicine is not a science. At least, not a science in its own right. The most important, key feature missing is repeatability, which makes the doctor's job extremely difficult. Doctors are not scientists, but every day, they are called upon to use the results of scientific research. Therefore, they must keep themselves updated, be able to distinguish what is really worth extricating from a huge amount of a literature and use the data exclusively in the interest of their patients. To be effective, medicine must start from a correct, full understanding of the problem, but when particulate pollution is involved, we see too many wrong diagnoses. This book is written by the discoverers of nanopathology and, therefore, is the most advanced in the field. The main topic is how natural, occasionally generated and engineered particles interfere with living organisms, food, drugs and the environment. The book is unique in the cases it shows and, in the methodology, used.
Enormous funds are currently being invested in nanotechnology, yet very little is known about how its products and by-products can interfere with both end users and people involved in their manufacture. Similar scenarios are already widely known in the history of science, such as the exploitation of radioactivity or the controversial issue of genet
Case Studies in Nanotoxicology and Particle Toxicology presents a highly-illustrated analysis of the most prominent cases on the adverse effects of nanoparticles and their impact on humans and the environment. This comprehensive reference demonstrates the possible risks imposed by managing and handling nanoparticles, showing the effects of involuntary inhalation or ingestion during their use and after their incineration. Through the use of numerous examples, readers will discover the possible risks and effects of working with nanoparticles, along with best practices to prevent these effects. The text is an essential reference for anyone working in the risk assessment of nanoparticles, including nanosafety professionals, occupational toxicologists, regulatory toxicologists, and clinicians.
Investigative tools for analyzing environmental nanoparticles with health impactsBasic theories and models of life cycle analysis applied to nanomaterialsConnects LCA, detection technologies and sustainability This book addresses the ways life cycle assessment (LCA) concepts can be applied to analyze the fate of nanoparticles in a variety of environmental and manufacturing settings. After introducing LCA theory and modeling concepts, the work discusses risks associated with carbon nanotubes, graphene, silver, fullerenes, iron oxides and other particles generated by manufacturing or medical diagnostics. Chapters in the text discuss biomolecules and the application of in vivo biosensors. Also covered are fate analysis, risk assessment, toxicology and nanopathology with a focus on human health and disease.
"Part of this book adapted from "Introduction aux nanosciences et aux nanotechnologies" published in France by Hermes Science/Lavoisier in 2006."
Reactive Oxygen Species (ROS), Nanoparticles, and Endoplasmic Reticulum (ER) Stress-Induced Cell Death Mechanisms presents the role of ROS?mediated pathways cellular signaling stress, endoplasmic reticulum (ER) stress, oxidative stress, oxidative damage, nanomaterials, and the mechanisms by which metalloids and nanoparticles induce their toxic effects. The book covers the ecotoxicology of environmental heavy metal ions and free radicals on macromolecules cells organisms, heavy metals?induced cell responses, oxidative stress, the source of oxidants, and the roles of ROS, oxidative stress and oxidative damage mechanisms. It also examines the nanotoxicity, cytotoxicity and genotoxicity mechanisms of nanomaterials and the effects of nanoparticle interactions. Antioxidant defense therapy and strategies for treatment round out the book, making it an ideal resource for researchers and professional scientists in toxicology, environmental chemistry, environmental science, nanomaterials and the pharmaceutical sciences. - Covers the ecotoxicology of environmental heavy metal ions and the interactions between specific heavy metals?induced cell responses and oxidative stress - Provides a better understanding of the mechanism of nanomaterial-induced toxicity as a first defense for hazard prevention - Covers recent advances in new nanomedication technologies for the effects of NPs on oxidative stress, ROS and ER stress - Discusses the effects of interactions between antioxidant defense therapy, ROS and strategies for treatment
This book results from a NATO Advanced Research Workshop titled “Technological Innovations in CBRNE Sensing and Detection for Safety, Security, and Sustainability” held in Yerevan, Armenia in 2012. The objective was to discuss and exchange views as to how fusion of advanced technologies can lead to improved sensors/detectors in support of defense, security, and situational awareness. The chapters range from policy and implementation, advanced sensor platforms using stand-off (THz and optical) and point-contact methods for detection of chemical, nuclear, biological, nuclear and explosive agents and contaminants in water, to synthesis methods for several materials used for sensors. In view of asymmetric, kinetic, and distributed nature of threat vectors, an emphasis is placed to examine new generation of sensors/detectors that utilize an ecosystems of innovation and advanced sciences convergence in support of effective counter-measures against CBRNE threats. The book will be of considerable interest and value to those already pursuing or considering careers in the field of nanostructured materials, and sensing/detection of CBRNE agents and water-borne contaminants. For policy implementation and compliance standpoint, the book serves as a resource of several informative contributions. In general, it serves as a valuable source of information for those interested in how nanomaterials and nanotechnologies are advancing the field of sensing and detection using nexus of advanced technologies for scientists, technologists, policy makers, and soldiers and commanders.
This edited volume brings together the expertise of numerous specialists on the topic of particles – their physical, chemical, pharmacological and toxicological characteristics – when they are a component of pharmaceutical products and formulations. The book discusses in detail properties such as the composition, size, shape, surface properties and porosity of particles with respect to how they impact the formulations and products in which they are used and the effective delivery of pharmaceutical active ingredients. It considers all dosage forms of pharmaceuticals involving particles, from powders to tablets, creams to ointments, and solutions to dry-powder inhalers, also including the latest nanomedicine products. Further, it discusses examples of particle toxicity, as well as the important subject of pharmaceutical industry regulations, guidelines and legislation. The book is of interest to researchers and practitioners who work on testing and developing pharmaceutical dosage and delivery systems.
This book presents varied clinical applications of nanomaterials in dentistry ranging from diagnostics to therapeutics. it discusses role of nanomaterials in clinical applications and future needs. Contributors are international luminaries in their respective research area. The topics covered in this book are role of nanomaterials in oral and dental diagnosis, dental disease prevention, pain free dentistry, dental implantology. It also discusses the therapeutic applications of nanoparticles in oral cancer therapy. This book will be a valuable reference for researchers, clinicians, students and professionals working in the areas of nanotechnology and health sciences. It will also be of interest to the students and researchers primarily working in the field of materials science, applied chemistry, applied physics, and biotechnology.