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The Nonhuman Primate in Drug Development and Safety Assessment is a valuable reference dedicated to compiling the latest research on nonhuman primate models in nonclinical safety assessment, regulatory toxicity testing and translational science. By covering important topics such as study planning and conduct, inter-species genetic drift, pathophysiology, animal welfare legislation, safety assessment of biologics and small molecules, immunotoxicology and much more, this book provides scientific and technical insights to help you safely and successfully use nonhuman primates in pharmaceutical toxicity testing. A comprehensive yet practical guide, this book is intended for new researchers or practicing toxicologists, toxicologic pathologists and pharmaceutical scientists working with nonhuman primates, as well as graduate students preparing for careers in this area. - Covers important topics such as species selection, study design, experimental methodologies, animal welfare and the 3Rs (Replace, Refine and Reduce), social housing, regulatory guidelines, comparative physiology, reproductive biology, genetic polymorphisms and more - Includes practical examples on techniques and methods to guide your daily practice - Offers a companion website with high-quality color illustrations, reference values for safety assessment and additional practical information such as study design considerations, techniques and procedures and dosing and sampling volumes
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The control of microbiological spoilage requires an understanding of a number of factors including the knowledge of possible hazards, their likely occurrence in different products, their physiological properties and the availability and effectiveness of different preventative measures. Food spoilage microorganisms focuses on the control of microbial spoilage and provides an understanding necessary to do this.The first part of this essential new book looks at tools, techniques and methods for the detection and analysis of microbial food spoilage with chapters focussing on analytical methods, predictive modelling and stability and shelf life assessment. The second part tackles the management of microbial food spoilage with particular reference to some of the major food groups where the types of spoilage, the causative microorganisms and methods for control are considered by product type. The following three parts are then dedicated to yeasts, moulds and bacteria in turn, and look in more detail at the major organisms of significance for food spoilage. In each chapter the taxonomy, spoilage characteristics, growth, survival and death characteristics, methods for detection and control options are discussed.Food spoilage microorganisms takes an applied approach to the subject and is an indispensable guide both for the microbiologist and the non-specialist, particularly those whose role involves microbial quality in food processing operations. - Looks at tools, techniques and methods for the detection and analysis of microbial food spoilage - Discusses the management control of microbial food spoilage - Looks in detail at yeasts, moulds and bacteria
This book presents the state-of-art marine metagenome research and explains the method of marine metagenomic analysis in an easy-to-understand manner. Changes in the marine environment due to global warming and pollution have become a major global problem. Maintaining a healthy marine ecosystem requires advanced environmental monitoring and assessment systems. As such, the book presents a novel metagenomic monitoring method, which has been developed for comprehensive analyses of the DNA of microorganisms living in seawater to further our understanding of the dynamics of the marine environment. The book can be used as a primer for new researchers and as a manual on experimental methods.
The second edition of Microbiology of Waterborne Diseases describes the diseases associated with water, their causative agents and the ways in which they gain access to water systems. The book is divided into sections covering bacteria, protozoa, and viruses. Other sections detail methods for detecting and identifying waterborne microorganisms, and the ways in which they are removed from water, including chlorine, ozone, and ultraviolet disinfection. The second edition of this handbook has been updated with information on biofilms and antimicrobial resistance. The impact of global warming and climate change phenomena on waterborne illnesses are also discussed. This book serves as an indispensable reference for public health microbiologists, water utility scientists, research water pollution microbiologists environmental health officers, consultants in communicable disease control and microbial water pollution students. Focuses on the microorganisms of most significance to public health, including E. coli, cryptosporidium, and enterovirus Highlights the basic microbiology, clinical features, survival in the environment, and gives a risk assessment for each pathogen Contains new material on antimicrobial resistance and biofilms Covers drinking water and both marine and freshwater recreational bathing waters
Providing full-color coverage of best practices, Head, Neck, and Orofacial Infections: An Interdisciplinary Approach, 2nd Edition, is an authoritative resource offering in-depth guidelines to the diagnosis and management of pathology due to severe infections. Comprehensive, evidence-based coverage presents both cutting-edge and time-tested approaches to recognizing and handling infections. From well-known academia and clinical educator James Hupp and accomplished surgeon Elie Ferneini, with chapters authored by expert contributors, this book is ideal for use as a clinical resource for a wide array of healthcare providers, as well as to prepare for licensure examination and board certification. NEW! Cutting-edge content covers microbiologic nomenclature, anti-microbial agents, understanding of viruses and anti-viral drugs, the management of patients during pandemics, and the team approach to managing infections of unknown origin or resistant to the usual treatment strategies. NEW! Full-color clinical images enhance understanding of key concepts in the text. NEW! eBook version, included with print purchase, provides access to all the text, figures, and references with the ability to search, customize content, make notes and highlights, and have content read aloud. UPDATED! Appendices include illustrative case reports. Comprehensive, easy-to-read coverage addresses the basic science, clinical diagnosis, and holistic management of a broad range of head, neck, and orofacial infections with both time-tested and cutting-edge approaches to patient management. More than 500 photographs, radiographs, and illustrations demonstrate pathologies, procedures, and outcomes. World-class authors and contributors share their expertise from the disciplines including infectious disease, head and neck surgery, oral and maxillofacial surgery, plastic surgery, and otolaryngology, as well as other disciplines involving severe infections of the head, neck, and orofacial regions. State-of-the-art guidance reflects extensive experience with current techniques, as well as technological advances in managing head, neck, and orofacial infections. A logical, sectioned approach to the content includes three sections: I) issues that are common to all infections of the head and neck region, II) infections of specific parts of the region, and III) infections related to certain procedures, types of patients, unusual organisms, and medical-legal implications.